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  • 3-表去氢土莫酸

    3-Epidehydrotumulosic acid

    3-表去氢土莫酸
    产品编号 CFN92743
    CAS编号 167775-54-4
    分子式 = 分子量 C31H48O4 = 484.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Wolfiporia cocos (Schw.) Ryv.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3-表去氢土莫酸 CFN92743 167775-54-4 1mg QQ客服:215959384
    3-表去氢土莫酸 CFN92743 167775-54-4 5mg QQ客服:215959384
    3-表去氢土莫酸 CFN92743 167775-54-4 10mg QQ客服:215959384
    3-表去氢土莫酸 CFN92743 167775-54-4 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • PLoS One.2015, 10(5):e0127060
  • Tumour Biol.2015, 36(9):7027-34
  • Molecules.2016, 21(10)
  • Plant Methods.2017, 13:108
  • Biochem Pharmacol.2017, 130:10-20
  • Evid Based Complement Alternat Med.2017, 2017:9764843
  • J Ethnopharmacol.2017, 206:73-77
  • Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
  • J Nat Prod.2017, 80(4):854-863
  • Int J Biol Macromol.2018, 112:1093-1103
  • Phytochemistry2018, 15:83-92
  • Molecules.2018, 23(2)
  • Molecules.2018, 23(3):E615
  • Biol Pharm Bull.2018, 41(11):1645-1651
  • Phytomedicine.2018, 47:48-57
  • J Agric Food Chem.2018, 66(1):351-358
  • Journal of Life Science2018, 917-922
  • J Sci Food Agric.2018, 98(3):1153-1161
  • Nat Prod Sci.2019, 25(3):238
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • The Malaysian journal of pathology2019, 41(3):243-251
  • Biochem Biophys Res Commun.2019, 518(4):732-738
  • Food Sci Nutr.2019, 8(1):246-256
  • ...
  • 生物活性
    Description: 3-Epidehydrotumulosic acid has inhibitory activity against AAPH-induced lysis of red blood cells.
    In vitro:
    J Nat Prod. 2002 Apr;65(4):462-5.
    Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.[Pubmed: 11975480]
    The structures of two novel 3,4-seco-lanostane-type triterpenes isolated from the sclerotium of Poria cocos were established to be 16alpha-hydroxy-3,4-seco-lanosta-4(28),8,24-triene-3,21-dioic acid (1; poricoic acid G) and 16alpha-hydroxy-3,4-seco-24-methyllanosta-4(28),8,24(24(1))-triene-3,21-dioic acid (2; poricoic acid H) on the basis of spectroscopic methods.
    METHODS AND RESULTS:
    These two, and eight other known compounds isolated from the sclerotium, poricoic acid B (3), poricoic acid A (4), tumulosic acid (5), dehydrotumulosic acid (6), 3-Epidehydrotumulosic acid (7), polyporenic acid C (8), 25-hydroxy-3-Epidehydrotumulosic acid (9), and dehydroabietic acid methyl ester (10), showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Evaluation of the cytotoxicity of compounds 1 and 4 against human cancer cell lines revealed that 1 was significantly cytotoxic to leukemia HL-60 cells [GI(50) (concentration that yields 50% growth) value 39.3 nM], although it showed only moderate cytotoxicity to the other cells. Compound 4 exhibited moderate cytotoxicity to all of the cancer cell lines tested.
    Phytother Res. 2003 Feb;17(2):160-2.
    Inhibitory effects of triterpenes isolated from Hoelen on free radical-induced lysis of red blood cells.[Pubmed: 12601680]
    Hoelen, sclederma of Poria cocos Wolf, has long been used as a sedative and diuretic in traditional medicine. Formerly, we demonstrated that Hoelen in vitro protects red blood cells from AAPH-induced hemolysis.
    METHODS AND RESULTS:
    In this study, tests were carried out to identify the main ingredient of Hoelen that has the scavenging effect on free-radicals. Triterpene carboxylic acids isolated from the methanol extract of Hoelen, i.e. pachymic acid, polyporenic acid, 3-Epidehydrotumulosic acid, 3beta-hydroxylanosta-7,9(11), 24-trien-21-oic acid and 3-o-acetyl-16 alpha -hydroxytrametenolic acid, were found to have inhibitory activities against AAPH-induced lysis of red blood cells.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0631 mL 10.3157 mL 20.6313 mL 41.2626 mL 51.5783 mL
    5 mM 0.4126 mL 2.0631 mL 4.1263 mL 8.2525 mL 10.3157 mL
    10 mM 0.2063 mL 1.0316 mL 2.0631 mL 4.1263 mL 5.1578 mL
    50 mM 0.0413 mL 0.2063 mL 0.4126 mL 0.8253 mL 1.0316 mL
    100 mM 0.0206 mL 0.1032 mL 0.2063 mL 0.4126 mL 0.5158 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    茯苓新酸A; Poricoic acid A(F) CFN92838 137551-38-3 C31H46O5 = 498.7 10mg QQ客服:1413575084
    Poricoic acid AE ; Poricoic acid AE CFN96980 1159753-88-4 C33H50O5 = 526.75 5mg QQ客服:1413575084
    24(31)-Dehydrocarboxyacetylquercinic acid; 24(31)-Dehydrocarboxyacetylquercinic acid CFN96179 127970-62-1 C34H50O7 = 570.8 5mg QQ客服:215959384
    齿孔酸; 齿孔菌酸; Eburicoic acid CFN90414 560-66-7 C31H50O3 = 470.73 5mg QQ客服:215959384
    茯苓酸; 茯灵酸; Pachymic acid CFN99590 29070-92-6 C33H52O5 = 528.76 20mg QQ客服:2932563308
    二氢齿孔酸; Dehydroeburicoic acid CFN92740 6879-05-6 C31H48O3 = 468.7 10mg QQ客服:3257982914
    去氢土莫酸; Dehydrotumulosic acid CFN92837 6754-16-1 C31H48O4 = 484.7 5mg QQ客服:3257982914
    去氢茯苓酸; Dehydropachymic acid CFN92742 77012-31-8 C33H50O5 = 526.8 10 mg QQ客服:2932563308
    3-表去氢土莫酸; 3-Epidehydrotumulosic acid CFN92743 167775-54-4 C31H48O4 = 484.7 5mg QQ客服:2932563308
    3-表去氢茯苓酸; 3-Epidehydropachymic acid CFN92738 168293-15-0 C33H50O5 = 526.8 5mg QQ客服:1413575084

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