• 中药标准品生产商,产品定制服务
  • 反式石竹烯

    trans-Caryophyllene

    反式石竹烯
    产品编号 CFN90502
    CAS编号 87-44-5
    分子式 = 分子量 C15H24 = 204.36
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Sesquiterpenoids
    植物来源 The seeds of Alpinia katsumadai Hayata.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    反式石竹烯 CFN90502 87-44-5 10mg QQ客服:2932563308
    反式石竹烯 CFN90502 87-44-5 20mg QQ客服:2932563308
    反式石竹烯 CFN90502 87-44-5 50mg QQ客服:2932563308
    反式石竹烯 CFN90502 87-44-5 100mg QQ客服:2932563308
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Católica Portuguesa (Portugal)
  • University of British Columbia (Canada)
  • Sapienza University of Rome (Italy)
  • University of Stirling (United Kingdom)
  • University of Limpopo (South Africa)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Universiti Malaysia Pahang (Malaysia)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Universiti Sains Malaysia (Malaysia)
  • University of Madras (India)
  • Universidade Federal de Santa Catarina (Brazil)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Lodz University of Technology (Poland)
  • Copenhagen University (Denmark)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Evid Based Complement Alternat Med.2015, 2015:165457
  • Phytother Res.2015, 29(7):1088-96
  • FEBS Lett.2015, 589(1):182-7
  • J Pharm Biomed Anal.2016, 129:50-59
  • Asian J Beauty Cosmetol2016, 14(3):249-257
  • Mediators Inflamm. 2016, 2016:6189590
  • J Drug Target.2016, 24:1-28
  • HortTechnology2016, 26(6):816-819
  • Vojnosanit Pregl2016, 75(00):391-391
  • African J. Agricultural Research 2017, 12(13):1164-1168
  • Int J Mol Sci.2017, 19(1)
  • J Ethnopharmacol.2017, 198:205-213
  • J Ethnopharmacol.2017, 198:87-90
  • Biol Pharm Bull.2017, 40(6):797-806
  • BMC Complement Altern Med.2018, 18(1):303
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • Life Sci.2018, 209:498-506
  • Molecules.2018, 23(7):E1659
  • J Mol Med (Berl).2018, 96(7):661-672
  • Enzyme Microb Technol.2019, 122:64-73
  • Microb Pathog.2019, 131:128-134
  • J of the Korean Society of Cosmetics and Cosmetology2019, 225-231
  • FASEB J.2019, 33(8):9685-9694
  • ...
  • 生物活性
    Description: trans-Caryophyllene, a PPAR-α agonist, which has neuroprotective effects in various neurological disorders, such as chemical induced seizure and brain damage. trans-Caryophyllene suppresses the hypoxia-induced neuroinflammatory response through inhibition of NF-κB activation in microglia.trans-Caryophyllene also reduces both acute and chronic pain in mice, which may be mediated through the opioid and endocannabinoid systems.
    Targets: PPAR | IL Receptor | TNF-α | SOD | ROS | NF-kB
    In vitro:
    Biochem Biophys Res Commun. 2014 Feb 21;444(4):451-4.
    A role for trans-caryophyllene in the moderation of insulin secretion.[Pubmed: 24486541]
    Glucose-stimulated insulin secretion (GSIS) is essential for the control of metabolic fuel homeostasis and its impairment is a key element in the failure of β-cells in type 2 diabetes.
    METHODS AND RESULTS:
    Trans-caryophyllene (TC), an important constituent of the essential oil of several species of plants, has been reported to activate the type 2 cannabinoid receptor (CB2R). The effects of TC on GSIS are still unknown. Our results demonstrate that administration of TC in MIN6 cells promotes GSIS in a dose dependent manner. However, inhibition of CB2R by a specific inhibitor or specific RNA interference abolished the effects of TC on GSIS, which suggests that the effects of TC on GSIS are dependent on activation of CB2R. Further study demonstrated that treatment with TC leads to the activation of small G protein Arf6 as well as Rac1 and Cdc42. Importantly, Arf6 silencing abolished the effects of TC on GSIS, which suggests that Arf6 participates in mediating the effects of TC on GSIS.
    CONCLUSIONS:
    We conclude from these data that TC has a novel role in regulating GSIS in pancreatic β-cells.
    J Mol Neurosci. 2014 Sep;54(1):41-8.
    Trans-caryophyllene suppresses hypoxia-induced neuroinflammatory responses by inhibiting NF-κB activation in microglia.[Pubmed: 24488604]
    trans-Caryophyllene (TC), may have protective effects against hypoxia-induced neuroinflammatory responses.
    METHODS AND RESULTS:
    In this study, trans-Caryophyllene was found to significantly inhibit hypoxia-induced cytotoxicity as well as the release of proinflammatory cytokines, including IL-1β, TNF-α, and IL-6, through activation of BV2 microglia following hypoxic exposure (1 % O2, 24 h). Furthermore, trans-Caryophyllene significantly inhibited hypoxia-induced generation of reactive oxygen species (ROS) in mitochondria as well as the activation of nuclear factor kappa B (NF-κB) in microglia. Importantly, trans-Caryophyllene 's effects on inhibiting the activation of NF-κB and the secretion of inflammatory cytokines can be abolished by muting the CB2R using small RNA interference.
    CONCLUSIONS:
    These observations indicate that trans-Caryophyllene suppresses the hypoxia-induced neuroinflammatory response through inhibition of NF-κB activation in microglia. Therefore, trans-Caryophyllene may be beneficial in preventing hypoxia-induced neuroinflammation.
    In vivo:
    Neurochem Res. 2015 Jan;40(1):118-23.
    Neuroprotective effects of trans-caryophyllene against kainic acid induced seizure activity and oxidative stress in mice.[Pubmed: 25417010]
    Trans-caryophyllene (TC), a component of essential oil found in many flowering plants, has shown its neuroprotective effects in various neurological disorders. However, the effects of TC on epilepsy haven't been reported before.
    METHODS AND RESULTS:
    In this study, we investigated the effect of TC on kainic acid-induced seizure activity caused by oxidative stress and pro-inflammation. We found that TC pretreatment significantly decreased seizure activity score compared to kainic acid treated group. Importantly, TC pretreatment leads to lowering the mortality in kainic acid treated mice. In addition, TC was found to significantly inhibit KA-induced generation of malondialdehyde. TC pretreatment also preserved the activity of GPx, SOD, and CAT. Notably, our data shows that an important property of TC is its capacity to exert cerebral anti-inflammatory effects by mitigating the expression of proinflammatory cytokines, such as TNF-α and IL-1β.
    CONCLUSIONS:
    These data suggest that TC has a potential protective effect on chemical induced seizure and brain damage.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.8933 mL 24.4666 mL 48.9333 mL 97.8665 mL 122.3331 mL
    5 mM 0.9787 mL 4.8933 mL 9.7867 mL 19.5733 mL 24.4666 mL
    10 mM 0.4893 mL 2.4467 mL 4.8933 mL 9.7867 mL 12.2333 mL
    50 mM 0.0979 mL 0.4893 mL 0.9787 mL 1.9573 mL 2.4467 mL
    100 mM 0.0489 mL 0.2447 mL 0.4893 mL 0.9787 mL 1.2233 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    反式石竹烯; trans-Caryophyllene CFN90502 87-44-5 C15H24 = 204.36 20mg QQ客服:2932563308
    石竹素; Caryophyllene oxide CFN99239 1139-30-6 C15H24O = 220.4 20mg QQ客服:215959384
    可布酮; Kobusone CFN98253 24173-71-5 C14H22O2 = 222.3 5mg QQ客服:3257982914
    α-石竹烯; Alpha-caryophyllene CFN93582 6753-98-6 C15H24 = 204.4 20mg QQ客服:2159513211
    花姜酮; Zerumbone CFN91066 471-05-6 C15H22O = 218.3 20mg QQ客服:3257982914
    环氧化蛇麻烯II; Humulene epoxide II CFN98008 19888-34-7 C15H24O = 220.4 5mg QQ客服:1413575084
    十氢-7,7,9a-三甲基-4-亚甲基-6H-环氧乙烯并[5,6]环壬烷并[1,2-b]呋喃-6-酮; Epoxyparvinolide CFN99039 102227-61-2 C15H22O3 = 250.3 5mg QQ客服:2932563308
    大牛儿烯 D; Germacrene D CFN93281 37839-63-7 C15H24 = 204.4 5mg QQ客服:2159513211
    环十五烷酮; Cyclopentadecanone CFN93169 502-72-7 C15H28O = 224.4 20mg QQ客服:1413575084
    麝香酮; Muscone CFN99518 541-91-3 C16H30O = 238.42 20mg QQ客服:215959384

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产