吴耳酸

Vulpic acid

	产品编号	CFN94427
	CAS编号	521-52-8
	分子式 = 分子量	C₁₉H₁₄O₅ = 322.32
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Miscellaneous
	植物来源	From lichen metabolites.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
吴耳酸	CFN94427	521-52-8	1mg	QQ客服：2056216494
吴耳酸	CFN94427	521-52-8	5mg	QQ客服：2056216494
吴耳酸	CFN94427	521-52-8	10mg	QQ客服：2056216494
吴耳酸	CFN94427	521-52-8	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Leibniz Institute of Plant Biochemistry (Germany)

University of Brasilia (Brazil)

University of Maryland (USA)

The Ohio State University (USA)

Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)

VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)

Hamdard University (India)

The Australian National University (Australia)

Chungnam National University (Korea)

Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)

Monash University Sunway Campus (Malaysia)

Universidade Federal de Goias (UFG) (Brazil)

Uniwersytet Medyczny w ?odzi (Poland)

Cancer Research Initatives Foundation(CARIF) (Malaysia)

More...

Description:

Vulpic acid has therapeutic and prophylactic potential to be antibacterial and antiplasmodial agents, it can inhibit one or more enzymes (PfFabI, PfFabG, and PfFabZ) from the plasmodial fatty acid biosynthesis (FAS-II) pathway, a potential drug target for liver stage activity.

Targets:

Fatty Acid Synthase

In vitro:

J Nat Prod. 2013 Jun 28;76(6):1064-70.

Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.[Pubmed: 23806111]

Chemicals targeting the liver stage (LS) of the malaria parasite are useful for causal prophylaxis of malaria.
METHODS AND RESULTS:
In this study, four lichen metabolites, evernic acid (1), Vulpic acid (2), psoromic acid (3), and (+)-usnic acid (4), were evaluated against LS parasites of Plasmodium berghei. Inhibition of P. falciparum blood stage (BS) parasites was also assessed to determine stage specificity. Compound 4 displayed the highest LS activity and stage specificity (LS IC50 value 2.3 μM, BS IC50 value 47.3 μM). The compounds 1-3 inhibited one or more enzymes (PfFabI, PfFabG, and PfFabZ) from the plasmodial fatty acid biosynthesis (FAS-II) pathway, a potential drug target for LS activity. To determine species specificity and to clarify the mechanism of reported antibacterial effects, 1-4 were also evaluated against FabI homologues and whole cells of various pathogens (S. aureus, E. coli, M. tuberculosis).
CONCLUSIONS:
Molecular modeling studies suggest that lichen acids act indirectly via binding to allosteric sites on the protein surface of the FAS-II enzymes. Potential toxicity of compounds was assessed in human hepatocyte and cancer cells (in vitro) as well as in a zebrafish model (in vivo). This study indicates the therapeutic and prophylactic potential of lichen metabolites as antibacterial and antiplasmodial agents.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
(2R,4S)-3,4-Dihydro-4-hydroxy-2,7-dimethyl-1(2H)-naphthalenone; (2R,4S)-3,4-Dihydro-4-hydroxy-2,7-dimethyl-1(2H)-naphthalenone	CFN95673	1932291-56-9	C₁₂H₁₄O₂ = 190.2	5mg	QQ客服：2056216494
Pyrolone B; Pyrolone B	CFN95694	1014978-30-3	C₁₂H₁₄O₃ = 206.2	mg	QQ客服：1457312923
(3R,4S)-REL-4-乙酰基-3,4-二氢-3,6,8-三羟基-3-甲基-1(2H)-萘酮; 4-(cis)-Acetyl-3,6,8-trihydroxy-3-methyldihydronaphthalenone	CFN97769	263368-92-9	C₁₃H₁₄O₅ = 250.25	5mg	QQ客服：2056216494
(3R,4R)-REL-4-乙酰基-3,4-二氢-3,6,8-三羟基-3-甲基-1(2H)-萘酮; 4-(trans)-Acetyl-3,6,8-trihydroxy-3-methyldihydronaphthalenone	CFN97770	263368-91-8	C₁₃H₁₄O₅ = 250.25	5mg	QQ客服：215959384
短叶苏木酚酸; Brevifolincarboxylic acid	CFN93653	18490-95-4	C₁₃H₈O₈ = 292.2	20mg	QQ客服：215959384
吴耳酸; Vulpic acid	CFN94427	521-52-8	C₁₉H₁₄O₅ = 322.32	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1025 mL	15.5125 mL	31.0251 mL	62.0501 mL	77.5627 mL
5 mM	0.6205 mL	3.1025 mL	6.205 mL	12.41 mL	15.5125 mL
10 mM	0.3103 mL	1.5513 mL	3.1025 mL	6.205 mL	7.7563 mL
50 mM	0.0621 mL	0.3103 mL	0.6205 mL	1.241 mL	1.5513 mL
100 mM	0.031 mL	0.1551 mL	0.3103 mL	0.6205 mL	0.7756 mL