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  • 鸭嘴花碱酮

    Vasicinolone

    鸭嘴花碱酮
    产品编号 CFN97406
    CAS编号 84847-50-7
    分子式 = 分子量 C11H10N2O3 = 218.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The leaves of Adhatoda vasica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    鸭嘴花碱酮 CFN97406 84847-50-7 1mg QQ客服:3257982914
    鸭嘴花碱酮 CFN97406 84847-50-7 5mg QQ客服:3257982914
    鸭嘴花碱酮 CFN97406 84847-50-7 10mg QQ客服:3257982914
    鸭嘴花碱酮 CFN97406 84847-50-7 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • National Cancer Center Research Institute (Japan)
  • Seoul National University (Korea)
  • Universitas islam negeri Jakarta (Indonesia)
  • Shanghai Institute of Organic Chemistry (China)
  • Uniwersytet Gdański (Poland)
  • Sanford Burnham Medical Research Institute (USA)
  • Universidade de Franca (Brazil)
  • Nanjing University of Chinese Medicine (China)
  • Wroclaw Medical University (Poland)
  • University of Maryland School of Medicine (USA)
  • Lund University (Sweden)
  • Universidade Católica Portuguesa (Portugal)
  • Kitasato University (Japan)
  • University Medical Center Mainz (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Addit Contam Part A Chem Anal Control Expo Risk Assess.2020, 37(9):1437-1448.
  • Talanta.2022, 249:123645.
  • The Journal of Animal & Plant Sciences.2020, 30(6):1366-1373
  • Antioxidants (Basel).2021, 10(10):1620.
  • LWT2020, 110397
  • Analytical Methods2018, 10(27)
  • Int J Mol Sci.2022, 23(24):16000.
  • Molecules.2016, 21(6)
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Emirates Journal of Food and Agriculture.2022, 34(6): 528-536.
  • Industrial Food Engineering2015, 19(4):408-413
  • J Appl Biol Chem.2021, 64(3),263?268
  • Archives of Biological sciences2022, 00:21-21
  • J Chromatogr Sci.2015, 53(5):824-9
  • Acta Physiologiae Plantarum2015, 37:1736
  • Int J Cosmet Sci.2023, 45(2):155-165.
  • Food Engineering Progress2019, 23(3)209-216
  • Int J Mol Sci.2018, 19(2)
  • Cell Chem Biol.2019, 26(1):27-34
  • Molecules2022, 27(9):2992.
  • Agronomy2020, 10(3),388.
  • J Korean Soc Food Sci Nutr2020, doi: 10.3746.
  • Journal of Food Composition and Analysis2021, 100:103905.
  • ...
  • 生物活性
    Description: Vasicinolone has anti-inflammatory, and antimicrobial activities.
    Targets: Antifection | Immunology & Inflammation related
    In vitro:
    PLoS One. 2015 Jun 5;10(6):e0129759.
    Correction: In Vitro and In Vivo Metabolism and Inhibitory Activities of Vasicine, a Potent Acetylcholinesterase and Butyrylcholinesterase Inhibitor.[Pubmed: 26046918]
    Vasicine (VAS), a potential natural cholinesterase inhibitor, exhibited promising anticholinesterase activity in preclinical models and has been in development for treatment of Alzheimer's disease.
    METHODS AND RESULTS:
    This study systematically investigated the in vitro and in vivo metabolism of VAS in rat using ultra performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight mass spectrometry. A total of 72 metabolites were found based on a detailed analysis of their 1H- NMR and 13C NMR data. Six key metabolites were isolated from rat urine and elucidated as vasicinone, vasicinol, Vasicinolone, 1,2,3,9-tetrahydropyrrolo [2,1-b] quinazolin-3-yl hydrogen sulfate, 9-oxo-1,2,3,9-tetrahydropyrrolo [2,1-b] quinazolin-3-yl hydrogen sulfate, and 1,2,3,9-tetrahydropyrrolo [2,1-b] quinazolin-3-β-D-glucuronide.
    Phytomedicine. 2013 Mar 15;20(5):441-5.
    Anti-inflammatory and antimicrobial properties of pyrroloquinazoline alkaloids from Adhatoda vasica Nees.[Pubmed: 23357363]
    Adhatoda vasica Nees, Acanthaceae, is well known plant in Ayurveda and Unani medicine. The purpose of this study was to characterize the most bioactive phytochemicals viz., vasicine, vasicinone, vasicine acetate, 2-acetyl benzyl amine, vasicinolone present in the chloroform fraction having anti-inflammatory and antimicrobial activities.
    METHODS AND RESULTS:
    The anti-inflammatory activity was tested by using carrageenan and CFA-model induced paw oedema. The antimicrobial activity of isolated compounds was assessed by using the microdilution method. The observed results revealed that vasicine showed most potent anti-inflammatory effects (59.51%) at the dose of 20.0mg/kg at 6h after carrageenan injection and maximum inhibition rate was observed of vasicinone (63.94%) at the dose of 10.0mg/kg at 4 days after CFA injection. The strong antibacterial activity was exhibited by vasicine at 20μg/ml dose against E. coli and also demonstrated maximum antifungal activity against C. albicans at the dose of >55μg/ml.
    CONCLUSIONS:
    All the five alkaloids demonstrated significant anti-inflammatory and antimicrobial activities.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.583 mL 22.9148 mL 45.8295 mL 91.659 mL 114.5738 mL
    5 mM 0.9166 mL 4.583 mL 9.1659 mL 18.3318 mL 22.9148 mL
    10 mM 0.4583 mL 2.2915 mL 4.583 mL 9.1659 mL 11.4574 mL
    50 mM 0.0917 mL 0.4583 mL 0.9166 mL 1.8332 mL 2.2915 mL
    100 mM 0.0458 mL 0.2291 mL 0.4583 mL 0.9166 mL 1.1457 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    常山乙素; Febrifugine CFN92302 24159-07-7 C16H19N3O3 = 301.3 20mg QQ客服:1457312923
    异常山乙素; Isofebrifugine CFN92303 32434-44-9 C16H19N3O3 = 301.3 20mg QQ客服:215959384
    Desoxypeganine; Desoxypeganine CFN91939 495-59-0 C11H12N2 = 172.23 5mg QQ客服:2159513211
    骆驼蓬碱; Vasicine CFN97052 6159-55-3 C11H12N2O = 188.2 10mg QQ客服:2159513211
    鸭嘴花酚碱; Vasicinol CFN99009 5081-51-6 C11H12N2O2 = 204.2 5mg QQ客服:1413575084
    脱氧鸭嘴花碱酮; Deoxyvasicinone CFN98882 530-53-0 C11H10N2O = 186.2 5mg QQ客服:1413575084
    鸭嘴花碱酮; Vasicinone CFN98773 486-64-6 C11H10N2O2 = 202.2 5mg QQ客服:1457312923
    鸭嘴花碱酮; Vasicinolone CFN97406 84847-50-7 C11H10N2O3 = 218.2 5mg QQ客服:1413575084
    薏苡素; Coixol CFN98889 532-91-2 C8H7NO3 = 165.1 20mg QQ客服:1457312923
    2,7-二羟基-2H-1,4-苯并嗪-3(4H)-酮; 2,7-Dihydroxy-2H-1,4-benzoxazin-3(4H)-one CFN97184 69804-59-7 C8H7NO4 = 181.1 5mg QQ客服:1413575084

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