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  • 茶黄素 3-没食子酸酯


    茶黄素 3-没食子酸酯
    产品编号 CFN90170
    CAS编号 30462-34-1
    分子式 = 分子量 C36H28O16 = 716.60
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The leaves of Black tea.
    产品名称 产品编号 CAS编号 包装 QQ客服
    茶黄素 3-没食子酸酯 CFN90170 30462-34-1 10mg QQ客服:2932563308
    茶黄素 3-没食子酸酯 CFN90170 30462-34-1 20mg QQ客服:2932563308
    茶黄素 3-没食子酸酯 CFN90170 30462-34-1 50mg QQ客服:2932563308
    茶黄素 3-没食子酸酯 CFN90170 30462-34-1 100mg QQ客服:2932563308
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  • 生物活性
    Description: Theaflavin-3-gallate has anticancer and apoptotic effects in non-small cell lung carcinoma, it acts as prooxidants and induce oxidative stress, with carcinoma cells more sensitive than normal fibroblasts. Theaflavin-3-gallate can play a role in decreased intestinal cholesterol absorption via inhibition of micelle formation.
    In vitro:
    Basic Clin Pharmacol Toxicol. 2008 Jul;103(1):66-74.
    Theaflavin-3-gallate and theaflavin-3'-gallate, polyphenols in black tea with prooxidant properties.[Pubmed: 18346048]
    This study compared the in vitro responses of human gingival fibroblasts and of carcinoma cells derived from the tongue to Theaflavin-3-gallate (TF-2A) and theaflavin-3'-gallate (TF-2B), polyphenols in black tea.
    The antiproliferative and cytotoxic effects of the theaflavin monomers were more pronounced to the carcinoma, than to the normal, cells. In phosphate buffer at pH 7.4, the theaflavins generated hydrogen peroxide and the superoxide anion, suggesting that their mode of toxicity may be due, in part, to the induction of oxidative stress. In a cell-free assay, Theaflavin-3-gallate and TF-2B reacted directly with reduced glutathione (GSH), in a time- and concentration-dependent manner. Intracellular storages of GSH were depleted on treatment of the cells with the theaflavin monomers. Depletion of intracellular GSH was more extensive with Theaflavin-3-gallate than with TF-2B and was more pronounced in the carcinoma, than in the normal, cells. The toxicities of the theaflavins were potentiated when the cells were cotreated with the GSH depleter, d,l-buthionine-[S,R]-sulfoximine. In the presence of catalase, pyruvate and divalent cobalt, all scavengers of reactive oxygen species, the cytotoxicities of the theaflavins were lessened. Theaflavin-3-gallate and TF-2B induced lipid peroxidation in the carcinoma cells, whereas in the fibroblasts, peroxidation was evident upon exposure to Theaflavin-3-gallate, but not to TF-2B.
    These studies demonstrated that the black tea theaflavin monomers, Theaflavin-3-gallate and TF-2B, act as prooxidants and induce oxidative stress, with carcinoma cells more sensitive than normal fibroblasts.
    Bangl. J. Pharmacol., 2015, 10(4):3047-53.
    Anticancer and apoptotic effects of theaflavin-3-gallate in non-small cell lung carcinoma.[Reference: WebLink]
    The objective was to determine the antiproliferative and apoptotic effects of Theaflavin-3-gallate in human non-small cell lung cancer cells (A-549) along with determining the effect on cell cycle phase distribution, cell migration and invasion.
    Cell viability was determined by MTT assay while as phase contrast and fluorescence microscopies were involved to study apoptotic morphologi-cal features in these cells. Flow cytometry investigated the effect of Theaflavin-3-gallate on cell cycle phase distribution. Theaflavin-3-gallate treatment led to a substantial cytotoxic effect in A-549 cancer cells with IC50 values of 42.1 μM and 27.9 μM at 24 and 48 hours respectively. Further, 80 and 160 μM dose of Theaflavin-3-gallate induced apoptotic features including chromatin margina-tion and micronuclei presence. The population of cells in G2/M phase increased from 2.7% (control) to 6.8%, 17.2% and finally to 46.5% after treatment with 20, 80 and 160 μM concentration of Theaflavin-3-gallate respectively indicating G2/M phase cell cycle arrest.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3955 mL 6.9774 mL 13.9548 mL 27.9096 mL 34.887 mL
    5 mM 0.2791 mL 1.3955 mL 2.791 mL 5.5819 mL 6.9774 mL
    10 mM 0.1395 mL 0.6977 mL 1.3955 mL 2.791 mL 3.4887 mL
    50 mM 0.0279 mL 0.1395 mL 0.2791 mL 0.5582 mL 0.6977 mL
    100 mM 0.014 mL 0.0698 mL 0.1395 mL 0.2791 mL 0.3489 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    茶黄素; Theaflavin CFN98597 4670-05-7 C29H24O12 = 564.49 20mg QQ客服:1148253675
    茶黄素 3'-没食子酸酯; Theaflavin-3'-gallate CFN98599 28543-07-9 C36H28O16 = 716.6 20mg QQ客服:2932563308
    茶黄素 3-没食子酸酯; Theaflavin-3-gallate CFN90170 30462-34-1 C36H28O16 = 716.60 20mg QQ客服:2932563308
    3,3'-二没食子酸酯茶黄素; Theaflavin 3,3'-di-O-gallate CFN99130 30462-35-2 C43H32O20 = 868.70 20mg QQ客服:1148253675
    (2R)-8-Methylsocotrin-4'-ol; (2R)-8-Methylsocotrin-4'-ol CFN92834 956103-75-6 C32H32O6 = 512.6 5mg QQ客服:1413575084
    血竭黄烷A; Dracoflavan A CFN92681 132185-42-3 C49H46O10 = 794.9 5mg QQ客服:1148253675
    狼毒色酮; Chamaechromone CFN92815 93413-00-4 C30H22O10 = 542.5 5mg QQ客服:3257982914





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