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  • 丁香亭

    Syringetin

    丁香亭
    产品编号 CFN70363
    CAS编号 4423-37-4
    分子式 = 分子量 C17H14O8 = 346.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Philydrum lanuginosum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    丁香亭 CFN70363 4423-37-4 1mg QQ客服:215959384
    丁香亭 CFN70363 4423-37-4 5mg QQ客服:215959384
    丁香亭 CFN70363 4423-37-4 10mg QQ客服:215959384
    丁香亭 CFN70363 4423-37-4 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Max-Planck-Insitut (Germany)
  • Universidade Federal de Santa Catarina (Brazil)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Instituto Politécnico de Bragan?a (Portugal)
  • University of Perugia (Italy)
  • Universidade de Franca (Brazil)
  • Anna University (India)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Universit?t Basel (Switzerland)
  • University of Liège (Belgium)
  • University of Minnesota (USA)
  • University of Lodz (Poland)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Deutsches Krebsforschungszentrum (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytomedicine.2022, 99:153997.
  • BMC Cancer. 2021, 21(1):91.
  • Oxid Med Cell Longev.2020, 2020:8887251.
  • Food Bioscience2022, 50:102187.
  • Biomed Pharmacother.2022, 156:113929.
  • J Holistic Integrative Pharm.2023, 4(1):14-28
  • BMC Complement Altern Med.2017, 17(1):393
  • Appl. Sci.2020, 10(20), 7323.
  • PLoS One.2018, 13(3):e0193386
  • Phytomedicine.2019, 65:153089
  • Int J Mol Sci.2022, 23(11):6104.
  • Theoretical and Experimental Plant Physiology 2022, 34,53-62
  • Phytother Res.2022, 35844057.
  • BMC Complement Med Ther. 2020, 20(1):91.
  • J Ethnopharmacol.2022, 282:114574.
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • Int Immunopharmacol.2021, 100:108073.
  • Antibiotics.2022, 11(4), 510.
  • Horticulturae2023, 9(2), 213.
  • Biosci Biotechnol Biochem.2020, 84(3):621-632
  • Plant Physiol Biochem.2021, 160:166-174.
  • Phytomedicine.2015, 22(4):498-503
  • Int J Mol Sci.2022, 23(5):2796.
  • ...
  • 生物活性
    Description: Syringetin prevents and treats bone metastasis in patients with lung cancer, it can directly inhibits osteoclastogenesis and reverses lung adenocarcinoma‑mediated osteoclastogenesis. Syringetin can increase BMP-2 synthesis, and subsequently activate SMAD1/5/8 and ERK1/2, and this effect may contribute to its action on the induction of osteoblast maturation and differentiation, followed by an increase of bone mass.
    Targets: ERK | SMAD | Akt | RANKL | mTOR | BMP-2
    In vitro:
    Oncology Reports, 2015.
    Syringetin suppresses osteoclastogenesis mediated by osteoblasts in human lung adenocarcinoma.[Reference: WebLink]
    Bone metastasis in lung cancer results in an unfavorable outcome for patients by not only impairing the quality of life, yet also increasing the cancer-related death rates.
    METHODS AND RESULTS:
    In the present study, we discuss a novel treatment strategy that may benefit these patients. Human CD14+ monocytes treated with macrophage-colony stimulating factor (M-CSF)/receptor activator of nuclear factor κB ligand (RANKL) differentiated into osteoclasts, whereas syringetin (SGN), a flavonoid derivative found in both grapes and wine, suppressed the osteoclastogenesis in vitro in a dose‑dependent manner. In addition, SGN inhibited osteoclast formation induced by human lung adenocarcinoma A549 and CL1-5 cells. The associated signaling transduction pathway in osteoclastogenesis and SGN inhibition was found to be via the AKT/mammalian target of rapamycin (mTOR) signaling pathway. Blocking AKT and mTOR by respective inhibitors significantly decreased lung adenocarcinoma-mediated osteoclastogenesis. Moreover, SGN regulated the lung adenocarcinoma-mediated interaction between osteoblasts and osteoclasts by suppressing the stimulatory effect of lung adenocarcinoma on M-CSF and RANKL production in osteoblasts, and reversing the inhibitory effect of the lung adenocarcinoma on OPG production in osteoblasts. The present study has two novel findings. It is the first to illustrate lung adenocarcinoma-mediated interaction between osteoblasts and osteoclasts, leading to osteolytic bone metastasis. It also reveals that SGN, a flavonoid derivative, directly inhibits osteoclastogenesis and reverses lung adenocarcinoma‑mediated osteoclastogenesis.
    CONCLUSIONS:
    In conclusion, the present study suggests that SGN, a natural compound, prevents and treats bone metastasis in patients with lung cancer.
    Molecular Nutrition & Food Research, 2009, 53(11):1452-1461.
    Syringetin, a flavonoid derivative in grape and wine, induces human osteoblast differentiation through bone morphogenetic protein-2/extracellular signal-regulated kinase 1/2 pathway.[Reference: WebLink]
    Syringetin (3,5,7,4'-tetrahydroxy-3',5'dimethoxyflavone), a flavonoid derivative, is present in grape and wine.
    METHODS AND RESULTS:
    By means of alkaline phosphatase (ALP) activity, osteocalcin, and type I collagen ELISA, we have shown that syringetin exhibits a significant induction of differentiation in MC3T3-E1 mouse calvaria osteoblasts and human fetal osteoblastic 1.19 cell line human osteoblasts. ALP and osteocalcin are phenotypic markers for early-stage differentiated osteoblasts and terminally differentiated osteoblasts, respectively. Our results indicate that syringetin stimulates osteoblast differentiation at various stages, from maturation to terminally differentiated osteoblasts. Induction of differentiation by syringetin is associated with increased bone morphogenetic protein-2 (BMP-2) production. The BMP-2 antagonist noggin blocked syringetin-mediated ALP activity and osteocalcin secretion enhancement, indicating that BMP-2 production is required in syringetin-mediated osteoblast maturation and differentiation. Induction of differentiation by syringetin is associated with increased activation of SMAD1/5/8 and extracellular signal-regulated kinase 1/2 (ERK1/2). Cotreatment of ERK1/2 inhibitor 2'-amino-3'-methoxyflavone inhibited syringetin-mediated ALP upregulation and osteocalcin production.
    CONCLUSIONS:
    In conclusion, syringetin increased BMP-2 synthesis, and subsequently activated SMAD1/5/8 and ERK1/2, and this effect may contribute to its action on the induction of osteoblast maturation and differentiation, followed by an increase of bone mass.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8877 mL 14.4383 mL 28.8767 mL 57.7534 mL 72.1917 mL
    5 mM 0.5775 mL 2.8877 mL 5.7753 mL 11.5507 mL 14.4383 mL
    10 mM 0.2888 mL 1.4438 mL 2.8877 mL 5.7753 mL 7.2192 mL
    50 mM 0.0578 mL 0.2888 mL 0.5775 mL 1.1551 mL 1.4438 mL
    100 mM 0.0289 mL 0.1444 mL 0.2888 mL 0.5775 mL 0.7219 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    丁香亭; Syringetin CFN70363 4423-37-4 C17H14O8 = 346.3 5mg QQ客服:1413575084
    3',4',5'-三甲氧基黄酮; 3',4',5'-Trimethoxyflavone CFN70439 67858-30-4 C18H16O5 = 312.3 10mg QQ客服:2159513211
    5,7-二羟基-3',4',5'-三甲氧基黄烷酮; 5,7-Dihydroxy-3',4',5'-trimethoxyflavanone CFN70425 62252-10-2 C18H18O7 = 346.3 5mg QQ客服:2056216494
    3,5,7-三羟基-3',4',5'-三甲氧基黄酮; 3,5,7-Trihydroxy-3',4',5'-trimethoxyflavone CFN70275 146132-95-8 C18H16O8 = 360.3 5mg QQ客服:215959384
    Combretol; Combretol CFN91118 5084-19-5 C20H20O8 = 388.4 10mg QQ客服:1413575084
    5,7,3',4',5'-五甲氧基黄酮; 5,7,3',4',5'-Pentamethoxyflavone CFN91117 53350-26-8 C20H20O7 = 372.4 20mg QQ客服:215959384
    8-羟基-3,5,7,3',4',5'-六甲氧基黄酮; 8-Hydroxy-3,5,7,3',4',5'-hexamethoxyflavone CFN98025 202846-95-5 C21H22O9 = 418.4 5mg QQ客服:1457312923
    3',4',5',3,5,7,8-七甲氧基黄酮; 3',4',5',3,5,7,8-Heptamethoxyflavone CFN98076 21634-52-6 C22H24O9 = 432.4 5mg QQ客服:215959384
    8-羟基-3,5,6,7,3',4'-六甲氧基黄酮; 8-Hydroxy-3,5,6,7,3',4'-hexamethoxyflavone CFN90998 1000415-56-4 C21H22O9 = 418.39 5mg QQ客服:215959384
    Natsudaidain; Natsudaidain CFN91804 35154-55-3 C21H22O9 = 418.4 5mg QQ客服:3257982914

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