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    苏齐内酯

    Suchilactone

    苏齐内酯
    产品编号 CFN95010
    CAS编号 50816-74-5
    分子式 = 分子量 C21H20O6 = 368.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The herbs of Haplophyllum pedicellatum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    苏齐内酯 CFN95010 50816-74-5 1mg QQ客服:1148253675
    苏齐内酯 CFN95010 50816-74-5 5mg QQ客服:1148253675
    苏齐内酯 CFN95010 50816-74-5 10mg QQ客服:1148253675
    苏齐内酯 CFN95010 50816-74-5 20mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Istanbul University (Turkey)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • University of Ioannina (Greece)
  • Max Rubner-Institut (MRI) (Germany)
  • University of Indonesia (Indonesia)
  • Mendel University in Brno (Czech Republic)
  • Universidade de Franca (Brazil)
  • University of Fribourg (Switzerland)
  • Monash University Malaysia (Malaysia)
  • Nanjing University of Chinese Medicine (China)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Anna University (India)
  • Complutense University of Madrid (Spain)
  • University of Lodz (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2015, 20(10):19172-88
  • Molecules.2015, 20(11):20014-30
  • Evid Based Complement Alternat Med.2016, 2016:1739760
  • Planta Med.2016, 82(13):1208-16
  • J Ethnopharmacol.2017, 206:73-77
  • Chin. Med.J.Res. Prac.2017, 31(4)
  • Pharm Biol.2017, 55(1):360-366
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Molecules.2018, 23(2)
  • Anticancer Res.2018, 38(4):2127-2135
  • Korean J. Crop Sci.2018, 63(2):131-139
  • Molecules.2019, 24(4):E709
  • J Ethnopharmacol.2019, 244:112074
  • Saudi Pharm J.2019, 27(1):145-153
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • J Agric Food Chem.2019, 67(27):7748-7754
  • Phytomedicine.2019, 67:153159
  • Ann Transl Med.2019, 7(23):731
  • Planta Med.2019, 85(3):217-224
  • Evid-Based Compl Alt2020, 7202519:13
  • Biosci Biotechnol Biochem.2020, 84(3):621-632
  • ...
  • 生物活性
    Description: Suchilactone may have the potential to be developed as a treatment of Alzheimer's Disease.
    Targets: Beta Amyloid
    In vivo:
    J Agric Food Chem. 2017 Apr 19;65(15):3133-3140.
    Protective Roles of Monsonia angustifolia and Its Active Compounds in Experimental Models of Alzheimer's Disease.[Pubmed: 28378593 ]
    Alzheimer's disease (AD), a progressive neurodegenerative disorder, is characterized by the accumulation of neurotoxic β-amyloid (Aβ) peptides, which consequently affects cognitive decline and memory impairment. Current research on AD treatment is actively focusing on the prevention of neurotoxic Aβ peptide accumulation. Monsonia angustifolia is reported to be consumed as an indigenous vegetable in Tanzania.
    METHODS AND RESULTS:
    In this study, we investigated the effect of the ethanol (EtOH) extract of M. angustifolia dried ground material on Aβ production and spatial learning ability as protection against AD. The formation of Aβ peptides was significantly reduced in HeLa cells stably transfected with the Swedish mutant form of β-amyloid precursor protein (APPsw) after treatment with a 60% EtOH extract of M. angustifolia. We next examined the cognitive-improving effects of the EtOH extract in vivo. Tg2576 mice were treated with extract for 6 months and subjected to Morris water maze and novel object recognition tests. The results showed that the 60% EtOH extract of M. angustifolia significantly ameliorated behavioral deficits of the AD transgenic mice and reduced the level of insoluble Aβ42 in the cerebral cortex and hippocampus. We further found that the 60% EtOH extract was effective for memory function recovery after shorter treatment (4 months). In addition, we isolated and identified several single compounds, justicidin A, 5-methoxyjusticidin A, chinensinaphthol, retrochinensinaphthol methyl ether, and suchilactone, from M. angustifolia and tested these compounds.
    CONCLUSIONS:
    Among them, justicidin A potently decreased the formation of Aβ in APPsw-transfected cells. These data suggest that the 60% EtOH extract of M. angustifolia has the potential to be developed as a treatment of AD. Furthermore, justicidin A may contribute, at least partially, to the Aβ alteration observed with the extract treatment.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7144 mL 13.5722 mL 27.1444 mL 54.2888 mL 67.861 mL
    5 mM 0.5429 mL 2.7144 mL 5.4289 mL 10.8578 mL 13.5722 mL
    10 mM 0.2714 mL 1.3572 mL 2.7144 mL 5.4289 mL 6.7861 mL
    50 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.0858 mL 1.3572 mL
    100 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.5429 mL 0.6786 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (+)-罗汉松树脂酚 ; (+)-Matairesinol CFN96715 148409-36-3 C20H22O6 = 358.39 5mg QQ客服:215959384
    Isosalicifolin; Isosalicifolin CFN96234 156974-99-1 C20H20O6 = 356.4 5mg QQ客服:215959384
    去甲络石甙元; Nortrachelogenin CFN98454 34444-37-6 C20H22O7 = 374.4 10mg QQ客服:2932563308
    荛花酚 ; (+)-Nortrachelogenin CFN96714 61521-74-2 C20H22O7 = 374.38 5mg QQ客服:2159513211
    (7R)-甲氧基-8-表-罗汉松树脂酚 ; (7R)-Methoxy-8-epi-matairesinol CFN89300 198827-23-5 C21H24O7 = 388.41 5mg QQ客服:3257982914
    络石苷元; Trachelogenin CFN90598 34209-69-3 C21H24O7 = 388.15 10mg QQ客服:2159513211
    去甲络石苷; Nortracheloside CFN93080 33464-78-7 C26H32O12 = 536.53 5mg QQ客服:1413575084
    络石苷; Tracheloside CFN90597 33464-71-0 C27H34O12 = 550.2 20mg QQ客服:2932563308
    络石苷元-4'-O-beta-龙胆二糖苷; Trachelogenin 4'-O-beta-gentiobioside CFN95235 106647-13-6 C33H44O17 = 712.7 10mg QQ客服:1148253675
    去甲络石苷元8'-O-β-葡萄糖苷; Nortrachelogenin-8'-O-beta-glucoside CFN95234 858127-38-5 C26H32O12 = 536.5 5mg QQ客服:215959384

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