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    Sodium Danshensu

    产品编号 CFN99163
    CAS编号 67920-52-9
    分子式 = 分子量 C9H9O5Na = 220.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The roots of Salvia miltiorrhiza Bge.
    产品名称 产品编号 CAS编号 包装 QQ客服
    丹参素钠 CFN99163 67920-52-9 10mg QQ客服:2932563308
    丹参素钠 CFN99163 67920-52-9 20mg QQ客服:2932563308
    丹参素钠 CFN99163 67920-52-9 50mg QQ客服:2932563308
    丹参素钠 CFN99163 67920-52-9 100mg QQ客服:2932563308
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    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

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  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • University of Malaya (Malaysia)
  • University of British Columbia (Canada)
  • University of Fribourg (Switzerland)
  • Medizinische Universit?t Wien (Austria)
  • Julius Kühn-Institut (Germany)
  • Georgia Institute of Technology (USA)
  • National Cancer Center Research Institute (Japan)
  • National Cancer Institute (USA)
  • Aveiro University (Portugal)
  • Korea Institute of Oriental Medicine (Korea)
  • Harvard University (USA)
  • University of Liège (Belgium)
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  • ...
  • 生物活性
    Description: Sodium danshensu (SDSS), the sodium salt of danshensu (DSS), has the neuroprotective effect against cerebral I/R injury, and the potential mechanism might to inhibition of apoptosis through activating the PI3K/Akt signal pathway. SDSS has a protective effect against the genotoxicity of cigarette smoke,it shows a biphasic effects on vessel tension, while low dosage of sodium danshensu produces small contraction possibly through transient enhancement of Ca(2+) influx, high dosage produces significant vasodilation mainly through promoting the opening of non-selective K(+) channels and small-conductance calcium-sensitive K(+) channels in the vascular smooth muscle cells.
    Targets: Calcium Channel | Potassium Channel | Akt | GSK-3 | Bcl-2/Bax | PI3K
    In vitro:
    Drugs & Clinic, 2014, 29(1):21-6.
    Protection of flavonoid components baicalein,quercetin,or sodium danshensu on cytotoxicity and cellular DNA damage induced by cigarette smoke[Reference: WebLink]
    To evaluate the protective effect of flavonoid components baicalein, quercetin or sodium danshensu on cytotoxicity and cellular DNA damage induced by cigarette smoke. Methods Two kinds of eukaryotic cells B-16 cells and oral buccal mucosal cells in liquid were attacked by the mainstream smoke produced via on-line cigarette smoking according to FTC with or without baicalein, quercetin or sodium danshensu. The cytotoxicity and cellular DNA damage were respectively assessed by MTT method and single cell gel electrophoresis. Results The cytotoxicity of B-16 cells and DNA damage of two kinds of cells induced by on-line cigarette smoking were obvious. A positive relationship was observed between the exposure time in smoke and the tail moment and olive tail moment of comet cells. Baicalein, quercetin, or sodium danshensu(1 mmol/L) could relieve the cytotoxicity by about 50% and decrease the DNA damage by more than 60%. Conclusion There is a positive relationship between the exposure of cells in smoke and the cellular DNA damage, and the flavonoid components baicalein, quercetin, or sodium danshensu have a protective effect against the genotoxicity of cigarette smoke.
    In vivo:
    Acta Pharmacol Sin. 2010 Apr;31(4):421-8.
    Biphasic effects of sodium danshensu on vessel function in isolated rat aorta.[Pubmed: 20228827]
    To investigate the effects of sodium danshensu on vessel function in isolated rat aortic ring.
    Thoracic aortae from normal rats were isolated and equilibrated in organ bath with Krebs-Henseleit buffer and ring tension was recorded. Effects of sodium danshensu on basal tonus of the vessel and its effects on vessel contraction and relaxation with or without endothelium were observed. In thoracic arteries under basal tonus, sodium danshensu (0.3-3 g/L) produced a dose-dependent transient contraction. In phenylephrine-precontracted thoracic arteries with or without endothelium, low concentration (0.1-0.3 g/L) of sodium danshensu produced a weak contraction, while high concentrations (1-3 g/L) produced a pronounced vasodilator after a transient vasocontraction. Pre-incubation with sodium danshensu could inhibit vessel contraction induced by phenylephrine and potassium chloride in a concentration-dependent way. Sodium danshensu inhibited phenylephrine- and CaCl(2)-induced vasoconstriction in Ca(2+)-free medium. Pre-incubation with tetraethylammonium, a non-selective K(+) channel blocker, and apamin, a small-conductance calcium-activated K(+) channel blocker partially antagonized the relaxation response induced by sodium danshensu. However, iberiotoxin (big-conductance calcium-sensitive K(+) channel blocker), barium chloride (inward rectifier K(+) channel blocker), and glibencalmide (ATP-sensitive K(+) channel blocker) had no influence on the vasodilation effect of sodium danshensu.
    Sodium danshensu showed a biphasic effects on vessel tension. While low dosage of sodium danshensu produced small contraction possibly through transient enhancement of Ca(2+) influx, high dosage produced significant vasodilation mainly through promoting the opening of non-selective K(+) channels and small-conductance calcium-sensitive K(+) channels in the vascular smooth muscle cells.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.5413 mL 22.7066 mL 45.4133 mL 90.8265 mL 113.5332 mL
    5 mM 0.9083 mL 4.5413 mL 9.0827 mL 18.1653 mL 22.7066 mL
    10 mM 0.4541 mL 2.2707 mL 4.5413 mL 9.0827 mL 11.3533 mL
    50 mM 0.0908 mL 0.4541 mL 0.9083 mL 1.8165 mL 2.2707 mL
    100 mM 0.0454 mL 0.2271 mL 0.4541 mL 0.9083 mL 1.1353 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Cinnamyl caffeate; Cinnamyl caffeate CFN89444 115610-32-7 C18H16O4 = 296.31 5mg QQ客服:1413575084
    香豆酸肉桂酯; Cinnamyl coumarate CFN89462 115610-30-5 C18H16O3 = 280.31 5mg QQ客服:3257982914
    (E)-Cinnamyl-(Z)-p-coumarate; (E)-Cinnamyl-(Z)-p-coumarate CFN89417 391682-51-2 C18H16O3 = 280.31 5mg QQ客服:1413575084
    异阿魏酸肉桂酯; Cinnamyl isoferulate CFN89441 115610-31-6 C19H18O4 = 310.34 5mg QQ客服:3257982914
    3-(2,4-二羟基苯基)丙酸; 3-(2,4-Dihydroxyphenyl)propionic acid CFN98940 5631-68-5 C9H10O4 = 182.2 20mg QQ客服:3257982914
    3-(2,4-二羟基苯基)丙酸甲酯; Methyl 3-(2,4-dihydroxyphenyl)propionate CFN99823 17422-90-1 C10H12O4 = 196.2 5mg QQ客服:1457312923
    丹参素; Danshensu CFN99539 22681-72-7 C9H10O5 = 198.17 20mg QQ客服:1457312923
    丹参素钠; Sodium Danshensu CFN99163 67920-52-9 C9H9O5Na = 220.2 20mg QQ客服:1413575084
    左旋多巴; Levodopa CFN99800 59-92-7 C9H11NO4 = 197.20 20mg QQ客服:1457312923
    Trans-咖啡酸; Trans-caffeic acid CFN92549 501-16-6 C9H8O4 = 180.2 20mg QQ客服:3257982914





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