咖啡酸乙酯

Ethyl caffeate

	产品编号	CFN97136
	CAS编号	66648-50-8
	分子式 = 分子量	C₁₁H₁₂O₄ = 208.2
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenylpropanoids
	植物来源	The roots of Ferula assafoetida L.
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产品名称	产品编号	CAS编号	包装	QQ客服
咖啡酸乙酯	CFN97136	66648-50-8	10mg	QQ客服：1413575084
咖啡酸乙酯	CFN97136	66648-50-8	20mg	QQ客服：1413575084
咖啡酸乙酯	CFN97136	66648-50-8	50mg	QQ客服：1413575084
咖啡酸乙酯	CFN97136	66648-50-8	100mg	QQ客服：1413575084

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Description:

Ethyl caffeate is a potent chemopreventive compound against skin carcinogenesis caused by solar UV exposure, it strongly inhibits neoplastic transformation of JB6 Cl41 cells without toxicity. PI3K, ERK1/2, and p38 kinase activities were suppressed by direct binding with HOEC in vitro. Ethyl caffeate also has anti-inflammatory, hepatprotective activities.

Targets:

PI3K | ERK | p38MAPK | AP-1 | NF-kB | Akt | NOS | COX | PGE

In vitro:

Chem Biol Interact. 2014 Aug 5;219:151-8.

A mechanistic study on the anti-cancer activity of ethyl caffeate in human ovarian cancer SKOV-3 cells.[Pubmed: 24892518 ]

In the present study, we investigated the effect and molecular mechanism of ethyl caffeate (EC), a natural phenolic compound isolated from Ligularia fischeri, on human ovarian cancer cell proliferation and progression.
METHODS AND RESULTS:
EC-mediated inhibition of cell proliferation in SKOV-3 cells was accompanied by reduced expression of cell cycle-related proteins such as cyclin-dependent kinases and cyclins, resulting in pRb hypophosphorylation and G₁ phase cell cycle arrest. Moreover, EC treatment markedly inhibited cell migration and invasion. These regulatory effects of EC on ovarian cancer cell proliferation, migration and invasion were associated with inactivation of mitogenic signaling pathways such as Akt, ERK and p38(MAPK), and down-regulation of cell surface signaling molecules including receptor tyrosine kinases, integrin α3β1 and N-cadherin.
CONCLUSIONS:
Taken together, these findings suggest further evaluation and development of EC for the treatment and prevention of ovarian cancer.

Br J Pharmacol. 2005 Oct;146(3):352-63.

Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin.[Pubmed: 16041399]

Ethyl caffeate, a natural phenolic compound, was isolated from Bidens pilosa, a medicinal plant popularly used for treating certain inflammatory syndromes. The purpose of this study was to investigate the structural activity, and the anti-inflammatory functions and mechanism(s) of Ethyl caffeate.
METHODS AND RESULTS:
Ethyl caffeate was found to markedly suppress the lipopolysaccharide (LPS)-induced nitric oxide (NO) production (IC(50) = 5.5 microg ml(-1)), mRNA and protein expressions of inducible nitric oxide synthase (iNOS), and prostaglandin E(2) (PGE(2)) production in RAW 264.7 macrophages. Transient gene expression assays using human cox-2 promoter construct revealed that Ethyl caffeate exerted an inhibitory effect on cox-2 transcriptional activity in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells. Immunohistochemical studies of mouse skin demonstrated that TPA-induced COX-2 expression was significantly inhibited by Ethyl caffeate with a superior effect to that of celecoxib, a nonsteroidal anti-inflammatory drug. The phosphorylation and degradation of inhibitor kappaB (IkappaB) and the translocation of nuclear transcription factor-kappaB (NF-kappaB) into the nucleus, as well as the activation of mitogen-activated protein kinases (MAPKs) induced by LPS in macrophages, were not affected by Ethyl caffeate. Ethyl caffeate, however, could inhibit NF-kappaB activation by impairing the binding of NF-kappaB to its cis-acting element. These results suggest that Ethyl caffeate suppresses iNOS and COX-2 expressions partly through the inhibition of the NF-kappaB.DNA complex formation. Structure-activity relationship analyses suggested that the catechol moiety and alpha,beta-unsaturated ester group in Ethyl caffeate are important and essential structural features for preventing NF-kappaB.DNA complex formation.
CONCLUSIONS:
This study provides an insight into the probable mechanism(s) underlying the anti-inflammatory and therapeutic properties of Ethyl caffeate.

In vivo:

J Sep Sci. 2009 Nov;32(21):3585-90.

Ethyl caffeate from Verdicchio wine: chromatographic purification and in vivo evaluation of its antifibrotic activity.[Pubmed: 19813225]

Ethyl caffeate (CfE, caffeic acid ethyl ester) was extracted from dealcoholized Verdicchio, a white wine from Marche (Italy) with ethyl acetate and then purified with semipreparative reversed-phase high-performance liquid chromatography (RP-HPLC) using an ODS2 column (25 cm x 20 mm id) at an isocratic flow of 5 mL/min (the mobile phase A was formic acid 4.5% in water and the mobile phase B was acetonitrile).
METHODS AND RESULTS:
The CfE extract administered intraperitoneally at 1 mumol/L in rats previously treated with 10 mg/kg dimethylnitrosamine was able to prevent the dimethylnitrosamine-induced loss in body and liver weight, as well as to reduce the degree of liver injury, as determined by alanine aminotransferase values and necroinflammatory score, after a 1-week treatment. This was associated with a reduced hepatic stellate cells activation (from 16.8 to 8.3% of smooth muscle actin positive parenchyma) and proliferation (from 11.3 to 5.5 cells/mm(2)). The collagen synthesis was also reduced: the percentage of Sirius Red positive parenchyma decreased from 21.7 to 7.2%.
CONCLUSIONS:
The CfE levels of Verdicchio wine determined with RP-HPLC-DAD were about 14 times the active levels tested in the in vivo test. CfE can be considered as a promising natural compound for future application in chronic liver disease.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
咖啡酸乙酯; Ethyl caffeate	CFN97136	66648-50-8	C₁₁H₁₂O₄ = 208.2	20mg	QQ客服：3257982914
咖啡酸苯乙酯; Caffeic acid phenethyl ester	CFN90554	104594-70-9	C₁₇H₁₆O₄ = 284.31	20mg	QQ客服：2056216494
Nepetoidin B; Nepetoidin B	CFN96779	55486-06-1	C₁₇H₁₄O₆ = 314.29	5mg	QQ客服：3257982914
Cinnamyl caffeate; Cinnamyl caffeate	CFN89444	115610-32-7	C₁₈H₁₆O₄ = 296.31	5mg	QQ客服：1413575084
香豆酸肉桂酯; Cinnamyl coumarate	CFN89462	115610-30-5	C₁₈H₁₆O₃ = 280.31	5mg	QQ客服：1413575084
(E)-Cinnamyl-(Z)-p-coumarate; (E)-Cinnamyl-(Z)-p-coumarate	CFN89417	391682-51-2	C₁₈H₁₆O₃ = 280.31	5mg	QQ客服：1457312923
异阿魏酸肉桂酯; Cinnamyl isoferulate	CFN89441	115610-31-6	C₁₉H₁₈O₄ = 310.34	5mg	QQ客服：2056216494
升麻消旋体A; Cimiracemate A	CFN95608	478294-16-5	C₁₉H₁₈O₇ = 358.4	10mg	QQ客服：1457312923
3-(2,4-二羟基苯基)丙酸; 3-(2,4-Dihydroxyphenyl)propionic acid	CFN98940	5631-68-5	C₉H₁₀O₄ = 182.2	20mg	QQ客服：1457312923
3-(2,4-二羟基苯基)丙酸甲酯; Methyl 3-(2,4-dihydroxyphenyl)propionate	CFN99823	17422-90-1	C₁₀H₁₂O₄ = 196.2	5mg	QQ客服：1457312923

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.8031 mL	24.0154 mL	48.0307 mL	96.0615 mL	120.0768 mL
5 mM	0.9606 mL	4.8031 mL	9.6061 mL	19.2123 mL	24.0154 mL
10 mM	0.4803 mL	2.4015 mL	4.8031 mL	9.6061 mL	12.0077 mL
50 mM	0.0961 mL	0.4803 mL	0.9606 mL	1.9212 mL	2.4015 mL
100 mM	0.048 mL	0.2402 mL	0.4803 mL	0.9606 mL	1.2008 mL

咖啡酸乙酯

Ethyl caffeate

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