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  • 戈米辛N

    Gomisin N

    戈米辛N
    产品编号 CFN90125
    CAS编号 69176-52-9
    分子式 = 分子量 C23H28O6 = 400.46
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The fruits of Schizandra chinensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    戈米辛N CFN90125 69176-52-9 10mg QQ客服:1148253675
    戈米辛N CFN90125 69176-52-9 20mg QQ客服:1148253675
    戈米辛N CFN90125 69176-52-9 50mg QQ客服:1148253675
    戈米辛N CFN90125 69176-52-9 100mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Utrecht University (Netherlands)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Medical University of South Carolina (USA)
  • Stanford University (USA)
  • University of Ioannina (Greece)
  • Deutsches Krebsforschungszentrum (Germany)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Nicolaus Copernicus Uniwersity (Poland)
  • University of Limpopo (South Africa)
  • Helmholtz Zentrum München (Germany)
  • Yale University (USA)
  • University of Stirling (United Kingdom)
  • Julius Kühn-Institut (Germany)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • British Jou. Med.&Med. Research2014, 1802-1811
  • Fitoterapia.2015, 100:179-86
  • Food Science and Biotechnology2015, 2205-2212
  • J Chromatogr Sci.2015, 53(5):824-9
  • J Pharm Biomed Anal2016, 118:183-194
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • Molecules.2016, 21(6)
  • Planta Med.2016, 82(13):1208-16
  • Tropical J. of Pha. Research2017, 16(3):543-552
  • International. J. of Food Properties 2017, 20:S131-S140
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • Aquaculture2017, 481:94-102
  • Pharm Biol.2017, 55(1):360-366
  • BMC Complement Altern Med.2018, 18(1):303
  • Biochem Biophys Res Commun.2018, 505(1):194-200
  • Primary and Industrial.2018, 52(11)
  • Chemistry of Natural Compounds2018, 54(3):572–576
  • Biomed Pharmacother.2019, 111:262-269
  • Int J Mol Sci.2019, 20(9):E2244
  • Molecules.2019, 24(24):E4536
  • Med Sci Monit.2019, 25:9499-9508
  • Journal of Apiculture2019, 34(2):131-136
  • Biosci Biotechnol Biochem.2020, 84(3):621-632
  • ...
  • 生物活性
    Description: Gomisin N has anti-oxdiant, anti-inflammatory, anti-cancer and anti-hepatitis activities; it produces beneficial sedative and hypnotic bioactivity, which may be mediated by the modification of the serotonergic and GABAergic system. Gomisin N can enhance TNF-α-induced apoptosis by suppressing of NF-κB and EGFR signaling pathways, and potentiate TRAIL-induced apoptosis through ROS-mediated up-regulation of death receptors 4 and 5.
    Targets: GABA Receptor | 5-HT Receptor | PARP | Caspase | ROS | NO | NOS | NF-kB | p65 | COX | IL Receptor | TNF-α | EGFR | IkB | Bcl-2/Bax | p53 | IKK
    In vitro:
    Immunopharmacol Immunotoxicol. 2011 Dec;33(4):709-13.
    Gomisin N has anti-allergic effect and inhibits inflammatory cytokine expression in mouse bone marrow-derived mast cells.[Pubmed: 21401384 ]
    Gomisin N is a bioactive compound and a prominent anti-allergic agent found in the fruits of tree Schizandra chinensis. However, its effects on the bone marrow-derived mast cell (BMMC)-mediated allergy and inflammation mechanism remain unknown.
    METHODS AND RESULTS:
    In this study, the biological effects of gomisin were evaluated while focusing on its effects on the allergic mediator in PMA + A23187-stimulated BMMCs. The anti-allergic effect of gomisin has shown that inhibited PMA + A23187-induced interleukin-6 (IL-6) production. An investigation was also conducted to determine its effects on the production of several allergic mediators including prostaglandin D(2) (PGD(2)), leukotriene C(4) (LTC(4)), β-hexosaminidase (β-Hex), and cyclooxygenase-2 (COX-2) protein. The results revealed that gomisin inhibited the PMA + A23187-induced production of IL-6, PGD(2), LTC(4), β-Hex, and COX-2 protein.
    CONCLUSIONS:
    Taken together, these findings indicate that gomisin N has the potential for use in the treatment of allergy.
    Mol Med Rep. 2009 Sep-Oct;2(5):725-32.
    Gomisin N isolated from Schisandra chinensis significantly induces anti-proliferative and pro-apoptotic effects in hepatic carcinoma.[Pubmed: 21475892]
    Lignans isolated from Schisandria chinensis have been prescribed as anti-cancer and anti-hepatitis treatments in Chinese medicine. To investigate the applications of lignans isolated from Schisandria chinensis in hepatic carcinoma therapy, their apoptotic ability was screened using a cell proliferation assay.
    METHODS AND RESULTS:
    Compared to the other lignans, gomisin N induced high apoptotic levels in hepatic carcinoma. Cell morphology and flow cytometric analysis demonstrated that this lignan induced cell death at high concentrations, but did not induce any changes at low concentrations. In addition, the expression levels of Bcl-2 and Bax proteins, which are involved in the apoptotic pathway, were markedly increased in only the 320 μM-treated group compared to the vehicle and other concentration groups, while the expression level of p53 protein remained unchanged in this group.
    CONCLUSIONS:
    These results suggest that gomisin N is an anti-cancer drug candidate capable of inhibiting the proliferation and inducing the apoptosis of human hepatic carcinomas.
    In vivo:
    Fitoterapia. 2014 Jul;96:123-30.
    Gomisin N isolated from Schisandra chinensis augments pentobarbital-induced sleep behaviors through the modification of the serotonergic and GABAergic system.[Pubmed: 24785966 ]
    The fruits of Schisandra chinensis have been used for the treatment of insomnia in oriental countries for more than thousands of years. However, the pharmacological properties and the mechanism of sedative and hypnotic effects have not yet been studied. Gomisin N is one of the major bioactive constituents from the fruits of Schisandra chinensis, and in this paper we reported a detailed study on the effects and mechanisms of Gomisin N on its sedative and hypnotic activity for the first time.
    METHODS AND RESULTS:
    These results implied that Gomisin N possessed weak sedative effects on locomotion activity in normal mice, and produced a dose-dependent(5-45 mg/kg, i.p.) increase in sleep duration in pentobarbital-treated mice, thus, itself did not induce sleep at higher dose which was used in this experiment (45 mg/kg, i.p.). It also can reverse the rodent models of insomnia induced by p-chlorophenylalanine (PCPA) and caffeine, which could exhibit a synergistic effect with 5-hydroxytryptophan (5-HTP) as well; furthermore, the hypnotic effects of Gomisin N were inhibited by flumazenil (a specific GABAA-BZD receptor antagonist).
    CONCLUSIONS:
    Altogether, these results indicated that Gomisin N produced beneficial sedative and hypnotic bioactivity, which might be mediated by the modification of the serotonergic and GABAergic system.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4971 mL 12.4856 mL 24.9713 mL 49.9426 mL 62.4282 mL
    5 mM 0.4994 mL 2.4971 mL 4.9943 mL 9.9885 mL 12.4856 mL
    10 mM 0.2497 mL 1.2486 mL 2.4971 mL 4.9943 mL 6.2428 mL
    50 mM 0.0499 mL 0.2497 mL 0.4994 mL 0.9989 mL 1.2486 mL
    100 mM 0.025 mL 0.1249 mL 0.2497 mL 0.4994 mL 0.6243 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    五脂酮C; Schisanlignone C CFN92723 144606-83-7 C23H26O7 = 414.5 5mg QQ客服:1413575084
    五味子丙素; Schizandrin C CFN99708 61301-33-5 C22H24O6 = 384.42 20mg QQ客服:2932563308
    五脂酮D; Schisanlignone D CFN92724 144606-84-8 C22H22O7 = 398.4 5mg QQ客服:215959384
    环氧五味子丙素; Schisandrin C epoxide CFN92841 81345-36-0 C22H22O7 = 398.4 5mg QQ客服:1413575084
    Rubrisandrin A; Rubrisandrin A CFN92278 919289-30-8 C22H28O6 = 388.5 5mg QQ客服:1413575084
    五味子甲素; Schizandrin A CFN99922 61281-38-7 C24H32O6 = 416.51 20mg QQ客服:2159513211
    五味子醇甲; Schisandrol A CFN99012 7432-28-2 C24H32O7 = 432.5 20mg QQ客服:1148253675
    五脂酮A; Schisanlignone A CFN92722 135557-67-4 C24H30O7 = 430.5 5mg QQ客服:2932563308
    戈米辛N; Gomisin N CFN90125 69176-52-9 C23H28O6 = 400.46 20mg QQ客服:2932563308
    五味子乙素; Schizandrin B CFN99923 61281-37-6 C23H28O6 = 400.47 20mg QQ客服:3257982914

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