岩茨烯A

Rehmannic acid

	产品编号	CFN97738
	CAS编号	467-81-2
	分子式 = 分子量	C₃₅H₅₂O₅ = 552.80
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The herbs of Lantana camara
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
岩茨烯A	CFN97738	467-81-2	1mg	QQ客服：1457312923
岩茨烯A	CFN97738	467-81-2	5mg	QQ客服：1457312923
岩茨烯A	CFN97738	467-81-2	10mg	QQ客服：1457312923
岩茨烯A	CFN97738	467-81-2	20mg	QQ客服：1457312923

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Hamdard University (India)

Yale University (USA)

University of Bonn (Germany)

National Hellenic Research Foundation (Greece)

University of Parma (Italy)

Universita' Degli Studi Di Cagliari (Italy)

Amity University (India)

Kyoto University (Japan)

Aarhus University (Denmark)

University of Melbourne (Australia)

University of Illinois at Chicago (USA)

Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)

University of Bordeaux (France)

Weizmann Institute of Science (Israel)

More...

Description:

Rehmannic acid and oleanolic acetate inhibit succinoxidase activity. Both Rehmannic acid and Icterogenin are potent uncouplers, abolishing the phosphate uptake, the respiration being inhibited by the former and increased by the latter.

Targets:

NADPH-oxidase

In vivo:

Biochemical Pharmacology.1968 Jun;17(6):1079–1089.

Inhibition of biliary secretion by icterogenin and related triterpenes-I. Effect of icterogenin, rehmannic acid and oleanolic acetate on liver mitochondria in vitro.[Reference: WebLink]

The effect of Icterogenin, Rehmannic acid and oleanolic acetate on respiration, mitochondrial structure and oxidative phosphorylation in rabbit and rat liver mitochondria was studied.
METHODS AND RESULTS:
All three substances at a concentration 1 × 1o−4 M and 5 × 10−5M inhibit the respiration of NAD-linked enzymes. Only Icterogenin in the concentration 1 × 10−5 M increased the respiration rate. The succinoxidase activity was inhibited by Rehmannic acid and oleanolic acetate. Icterogenin at the concentrations 1 × 10−4 M and 5 × 10−5 M did not cause any definite changes in respiration with succinate as substrate, but at the concentration 1 × 10-5 M the respiration was always increased.The substances were found to increase the mitochondrial membrane permeability and Icterogenin had a swelling effect of the large amplitude type. The oxidative phosphorylation was uncoupled by Icterogenin and Rehmannic acid and inhibited by oleanolic acetate. Rehmannic acid at a concentration 5 × 10−5 M almost completely abolished the phosphate uptake when glutamate was used as substrate. The effect of Icterogenin was less. The respiration with glutamate as substrate was inhibited 50 per cent by the former and to about 25 per cent by the latter.
CONCLUSIONS:
With succinate as substrate, both Rehmannic acid and Icterogenin were potent uncouplers, abolishing the phosphate uptake, the respiration being inhibited by the former and increased by the latter. The connection between chemical structure and effect on oxidative phosphorylation is discussed.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
路路通内酯; Liquidambaric lactone	CFN90155	185051-75-6	C₃₀H₄₄O₄ = 468.67	5mg	QQ客服：2159513211
3beta-乙酰氧基-11alpha,12alpha-环氧齐墩果烷-13beta,28-内酯; 3beta-Acetoxy-11alpha,12alpha-epoxyoleanan-28,13beta-olide	CFN96374	35738-25-1	C₃₂H₄₈O₅ = 512.7	5mg	QQ客服：3257982914
16-脱氧柴胡甙元 F; 16-Deoxysaikogenin F	CFN96265	57475-62-4	C₃₀H₄₈O₃ = 456.7	5mg	QQ客服：2056216494
11alpha,12alpha-Epoxy-3beta,23-dihydroxy-30-norolean-20(29)-en-28,13beta-olide ; 11alpha,12alpha-Epoxy-3beta,23-dihydroxy-30-norolean-20(29)-en-28,13beta-olide	CFN96095	186140-36-3	C₂₉H₄₂O₅ = 470.7	5mg	QQ客服：2056216494
3-O-Acetyloleanderolide; 3-O-Acetyloleanderolide	CFN97080	62498-83-3	C₃₂H₅₀O₅ = 514.8	5mg	QQ客服：3257982914
Sculponeatic acid; Sculponeatic acid	CFN99269	1169806-02-3	C₃₀H₄₆O₄ = 470.7	5mg	QQ客服：1457312923
黄莲木酸; Moronic acid	CFN97145	6713-27-5	C₃₀H₄₆O₃ = 454.7	5mg	QQ客服：1457312923
Pyrocincholic acid methyl ester; Pyrocincholic acid methyl ester	CFN99079	107160-24-7	C₃₀H₄₈O₃ = 456.7	5mg	QQ客服：2159513211
苦杏酸; Camaric acid	CFN99606	146450-83-1	C₃₅H₅₂O₆ = 568.8	5mg	QQ客服：1413575084
岩茨烯A; Rehmannic acid	CFN97738	467-81-2	C₃₅H₅₂O₅ = 552.80	5mg	QQ客服：2159513211

信息支持

公司简介
订购流程
付款方式
退换货政策

ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

联系方式

电机：027-84237783
传真：027-84254680
在线QQ: 1413575084
E-Mail：manager@chemfaces.com

湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房

ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.809 mL	9.0449 mL	18.0897 mL	36.1795 mL	45.2243 mL
5 mM	0.3618 mL	1.809 mL	3.6179 mL	7.2359 mL	9.0449 mL
10 mM	0.1809 mL	0.9045 mL	1.809 mL	3.6179 mL	4.5224 mL
50 mM	0.0362 mL	0.1809 mL	0.3618 mL	0.7236 mL	0.9045 mL
100 mM	0.0181 mL	0.0904 mL	0.1809 mL	0.3618 mL	0.4522 mL