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  • 苦玄参苷IA

    • 苦玄参苷IA

    Picfeltarraenin IA

    苦玄参苷IA
    		产品编号 CFN99942
    CAS编号 97230-47-2
    分子式 = 分子量 C41H62O13 = 762.92
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Picria felterrae Lour.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    苦玄参苷IA CFN99942 97230-47-2 10mg QQ客服：215959384
    苦玄参苷IA CFN99942 97230-47-2 20mg QQ客服：215959384
    苦玄参苷IA CFN99942 97230-47-2 50mg QQ客服：215959384
    苦玄参苷IA CFN99942 97230-47-2 100mg QQ客服：215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Calcutta University (India)
  • Wroclaw Medical University (Poland)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Gyeongsang National University (Korea)
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  • Imperial College London (United Kingdom)
  • Universit?t Basel (Switzerland)
  • Amity University (India)
  • Shanghai University of TCM (China)
  • Washington State University (USA)
  • Semmelweis Unicersity (Hungary)
  • University of Mysore (India)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Neurochem Int.2018, 121:114-124
  • Preprints2022, 202211.0388.v1.
  • Antioxidants.2022, 11(3):592.
  • J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
  • Molecules2022, 27(11):3606.
  • Planta Medica International2022, 9(01):e108-e115.
  • Int J Mol Sci.2020, 21(22):8816.
  • Oncotarget.2015, 6(31):30831-49
  • Antioxidants (Basel).2021, 10(8):1300.
  • Med Sci Monit.2019, 25:9499-9508
  • Oxid Med Cell Longev.2021, 2021:6647107.
  • Front Cell Dev Biol.2021, 9:588093.
  • Plant Archives2020, 2(1),2929-2934
  • Molecules.2019, 24(16):E2985
  • Microchemical Journal2024: 196:109676.
  • Molecules.2020 ,25(16):3697.
  • Int J Pharmacol2020, 16:1-9
  • Journal of Functional Foods2022, 98:105271.
  • SBRAS2016, 12
  • Key Engineering Materials2022, 931(47-53).
  • Pharmacognosy Journal2019, 11(2): 369-373
  • Sci. Rep.2015, 14-23
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • ...
    • 生物活性
    Description: Picfeltarraenin IA has anti-inflammatory activity, it is a strong AChE inhibitior, and an potential PI3K and epidermal growth factor receptor (EGFR ) inhibitor. It acts as an inhibitor on both the classical and alternative pathways of the complement system.
    Targets: IL Receptor | PGE | NF-kB | COX | p65 | EGFR | PI3K | Akt
    In vitro:
    Oncol Lett. 2016 Feb;11(2):1195-1200.
    Picfeltarraenin IA inhibits lipopolysaccharide-induced inflammatory cytokine production by the nuclear factor-κB pathway in human pulmonary epithelial A549 cells.[Pubmed: 26893718 ]
    The present study aimed to investigate the effect of Picfeltarraenin IA (IA) on respiratory inflammation by analyzing its effect on interleukin (IL)-8 and prostaglandin E2 (PGE2) production. The expression of cyclooxygenase 2 (COX2) in human pulmonary adenocarcinoma epithelial A549 cells in culture was also examined.
    METHODS AND RESULTS:
    Human pulmonary epithelial A549 cells and the human monocytic leukemia THP-1 cell line were used in the current study. Cell viability was measured using a methylthiazol tetrazolium assay. The production of IL-8 and PGE2 was investigated using an enzyme-linked immunosorbent assay. The expression of COX2 and nuclear factor-κB (NF-κB)-p65 was examined using western blot analysis. Treatment with lipopolysaccharide (LPS; 10 μg/ml) resulted in the increased production of IL-8 and PGE2, and the increased expression of COX2 in the A549 cells. Furthermore, IA (0.1-10 μmol/l) significantly inhibited PGE2 production and COX2 expression in cells with LPS-induced IL-8, in a concentration-dependent manner. The results suggested that IA downregulates LPS-induced COX2 expression, and inhibits IL-8 and PGE2 production in pulmonary epithelial cells. Additionally, IA was observed to suppress the expression of COX2 in THP-1 cells, and also to regulate the expression of COX2 via the NF-κB pathway in the A549 cells, but not in the THP-1 cells.
    CONCLUSIONS:
    These results indicate that IA regulates LPS-induced cytokine release in A549 cells via the NF-κB pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3108 mL 6.5538 mL 13.1075 mL 26.2151 mL 32.7688 mL
    5 mM 0.2622 mL 1.3108 mL 2.6215 mL 5.243 mL 6.5538 mL
    10 mM 0.1311 mL 0.6554 mL 1.3108 mL 2.6215 mL 3.2769 mL
    50 mM 0.0262 mL 0.1311 mL 0.2622 mL 0.5243 mL 0.6554 mL
    100 mM 0.0131 mL 0.0655 mL 0.1311 mL 0.2622 mL 0.3277 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    泽泻醇 K 23-醋酸酯; Alisol K 23-acetate CFN92405 228095-18-9 C32H46O6 = 526.7 5mg QQ客服：2159513211
    苦玄参苷IA; Picfeltarraenin IA CFN99942 97230-47-2 C41H62O13 = 762.92 20mg QQ客服：3257982914
    苦玄参苷IB; Picfeltarraenin IB CFN90712 97230-46-1 C42H64O14 = 792.95 20mg QQ客服：1413575084
    苦玄参苷IV; Picfeltarraenin IV CFN90719 184288-35-5 C47H72O18 = 925.06 5mg QQ客服：1413575084
    苦玄参苷X; Picfeltarraenin X CFN90730 1391826-61-1 C36H54O11 = 662.81 5mg QQ客服：1413575084
    16,23-氧化泽泻醇B; 16,23-Oxidoalisol B CFN95650 169326-06-1 C30H46O4 = 470.7 5mg QQ客服：2056216494
    泽泻醇F; Alisol F CFN92402 155521-45-2 C30H48O5 = 488.7 10mg QQ客服：215959384
    25-甲基泽泻醇F; 25-Methoxyalisol F CFN95657 2221029-53-2 C31H50O5 = 502.7 5mg QQ客服：2056216494
    24-去乙酰泽泻醇O; 24-Deacetylalisol O CFN92407 1067510-31-9 C30H46O4 = 470.7 5mg QQ客服：1413575084
    泽泻醇O; Alisol O CFN92404 928148-51-0 C32H48O5 = 512.7 5mg QQ客服：1457312923

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