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  • 连翘苷

    Phillyrin

    连翘苷
    产品编号 CFN99998
    CAS编号 487-41-2
    分子式 = 分子量 C27H34O11 = 534.56
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The fruits of Forsythia suspensa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    连翘苷 CFN99998 487-41-2 10mg QQ客服:2159513211
    连翘苷 CFN99998 487-41-2 20mg QQ客服:2159513211
    连翘苷 CFN99998 487-41-2 50mg QQ客服:2159513211
    连翘苷 CFN99998 487-41-2 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Celltrion Chemical Research Institute (Korea)
  • Center for protein Engineering (CIP) (Belgium)
  • University of Illinois (USA)
  • Max Rubner-Institut (MRI) (Germany)
  • University Medical Center Mainz (Germany)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Medizinische Universit?t Wien (Austria)
  • Wroclaw Medical University (Poland)
  • The Institute of Cancer Research (United Kingdom)
  • University of Maryland (USA)
  • Weizmann Institute of Science (Israel)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • University of Wuerzburg (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • British Jou. Med.&Med. Research2014, 1802-1811
  • Auburn University2015, 1-58
  • Sci Rep.2015, 5:13194
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • Analytical sci. & Tech2016, 186-193
  • Nat Prod Sci.2016, 22(2)
  • J Drug Target.2016, 24:1-28
  • HortTechnology2016, 26(6):816-819
  • BMC Complement Altern Med.2017, 17(1):384
  • Int J Mol Sci.2017, 19(1)
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Sci Rep. 2018, 10590
  • J of Engineering Science&Technology2018, 13(9):2820-2828
  • Mol Cells.2018, 41(8):771-780
  • Pharmacognosy Journal2019, 11(2): 369-373
  • Microb Pathog.2019, 131:128-134
  • J Med Food.2019, 22(10):1067-1077
  • FASEB J.2019, 33(2):2026-2036
  • Academic J of Second Military Medical University2019, 40(1)
  • Phytomedicine.2019, 67:153159
  • Br J Pharmacol.2020, 10.1111
  • Front Plant Sci.2020, 10:1705
  • ...
  • 生物活性
    Description: Phillyrin is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activation. Phillyrin may be a new preventive agent of acute lung injury in the clinical setting, it potentially contributes to the suppression of the activation of MAPK and NF-κB pathways, it also has protective effects on H2O2-induced oxidative stress and apoptosis in PC12 cells.
    Targets: Fatty Acid Synthase | AMPK | ROS | Bcl-2/Bax | TNF-α | IL Receptor | MAPK | NF-kB
    In vitro:
    Food Chem. 2013 Jan 15;136(2):415-25.
    Phillyrin attenuates high glucose-induced lipid accumulation in human HepG2 hepatocytes through the activation of LKB1/AMP-activated protein kinase-dependent signalling.[Pubmed: 23122079]
    Phillyrin, an active constituent found in many medicinal plants and certain functional foods, has anti-obesity activity in vivo. The aim of our study was to provide new data on the molecular mechanism(s) underlying the role of phillyrin in the prevention of high glucose-induced lipid accumulation in human HepG2 hepatocytes.
    METHODS AND RESULTS:
    We found that phillyrin suppressed high glucose-induced lipid accumulation in HepG2 cells. Phillyrin strongly inhibited high glucose-induced fatty acid synthase (FAS) expression by modulating sterol regulatory element-binding protein-1c (SREBP-1c) activation. Moreover, use of the pharmacological AMP-activated protein kinase (AMPK) inhibitor compound C revealed that AMPK is essential for suppressing SREBP-1c expression in phillyrin-treated cells. Finally, we found that liver kinase B1 (LKB1) phosphorylation is required for the phillyrin-enhanced activation of AMPK in HepG2 hepatocytes.
    CONCLUSIONS:
    These results indicate that phillyrin prevents lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activation, suggesting that phillyrin is a novel AMPK activator with a role in the prevention and treatment of obesity.
    In vivo:
    Zhong Yao Cai. 2005 Feb;28(2):123-4.
    [Effect of phillyrin on the anti-obesity in nutritive obesity mice].[Pubmed: 15981888]
    To study on the anti-obesity effect of phillyrin in nutritive obesity mice.
    METHODS AND RESULTS:
    The alimentary obesity model was established by hyperalimentation. The wet weight of fat, fat index, number of fat cells per unit visual field, Lee's index, jejunum microvillus area, serum triglyceride and cholesterol were selected to observe the anti-obesity effect of phillyrin. Phillyrin could lower wet weight of fat (P < 0.01), fat index (P < 0.05 or P < 0.01), diameter of fat cell and Lee's index (P < 0.05), decrease the jejunum microvillus area, lower the level of serum triglyceride and cholesterol.
    CONCLUSIONS:
    Phillyrin has anti-obesity effect in nutritive obesity mice.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8707 mL 9.3535 mL 18.707 mL 37.4139 mL 46.7674 mL
    5 mM 0.3741 mL 1.8707 mL 3.7414 mL 7.4828 mL 9.3535 mL
    10 mM 0.1871 mL 0.9353 mL 1.8707 mL 3.7414 mL 4.6767 mL
    50 mM 0.0374 mL 0.1871 mL 0.3741 mL 0.7483 mL 0.9353 mL
    100 mM 0.0187 mL 0.0935 mL 0.1871 mL 0.3741 mL 0.4677 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    连翘苷; Phillyrin CFN99998 487-41-2 C27H34O11 = 534.56 20mg QQ客服:1413575084
    辛夷脂素; Fargesin CFN98174 31008-19-2 C21H22O6 = 370.39 20mg QQ客服:2932563308
    细辛脂素; Asarinin CFN90628 133-05-1 C20H18O6 = 354.35 20mg QQ客服:3257982914
    刺五加苷D; Eleutheroside D CFN98510 79484-75-6 C34H46O18 = 742.72 10mg QQ客服:2159513211
    刺五加苷 E; Eleutheroside E CFN99984 39432-56-9 C34H46O18 = 742.73 20mg QQ客服:2932563308
    (-)-松脂醇; (-)-Pinoresinol CFN92287 81446-29-9 C20H22O6 = 358.4 5mg QQ客服:2159513211
    (-)-丁香树脂酚; (-)-Syringaresinol CFN92500 6216-81-5 C22H26O8 = 418.4 5mg QQ客服:1413575084
    Hedyotisol A; Hedyotisol A CFN97537 95732-59-5 C42H50O16 = 810.9 5mg QQ客服:2932563308
    Hedyotisol B; Hedyotisol B CFN97877 95839-45-5 C42H50O16 = 810.9 5mg QQ客服:215959384
    (-)-丁香树脂酚-4-O-beta-D-呋喃芹糖基-(1→2)-beta-D-吡喃葡萄糖苷; (-)-Syringaresinol 4-(2''-apiosylglucoside) CFN99504 136997-64-3 C33H44O17 = 712.69 10mg QQ客服:2159513211

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