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    (-)-松脂醇

    (-)-Pinoresinol

    (-)-松脂醇
    产品编号 CFN92287
    CAS编号 81446-29-9
    分子式 = 分子量 C20H22O6 = 358.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The barks of Eucommia ulmoides
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    (-)-松脂醇 CFN92287 81446-29-9 1mg QQ客服:2932563308
    (-)-松脂醇 CFN92287 81446-29-9 5mg QQ客服:2932563308
    (-)-松脂醇 CFN92287 81446-29-9 10mg QQ客服:2932563308
    (-)-松脂醇 CFN92287 81446-29-9 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • National Cancer Institute (USA)
  • University of Parma (Italy)
  • Sant Gadge Baba Amravati University (India)
  • University of Vigo (Spain)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Calcutta University (India)
  • University of Fribourg (Switzerland)
  • Subang Jaya Medical Centre (Malaysia)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • National Hellenic Research Foundation (Greece)
  • Wroclaw Medical University (Poland)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Korea Institute of Oriental Medicine (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2014, 14:352
  • New Zealand J. Forestry Sci.2014, 44:17
  • Food Science and Biotechnology2015, 2205-2212
  • Molecules.2016, 21(6)
  • Org Biomol Chem.2017, 15(31):6483-6492
  • BMC Complement Altern Med.2017, 17(1):384
  • J Nat Med.2017, 71(2):457-462
  • J Sep Sci.2018, 41(7):1682-1690
  • J Sci Food Agric.2018, 98(3):1153-1161
  • Nat Commun.2019, 10(1):5169
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1113:1-13
  • Int J Mol Sci.2019, 20(21):E5488
  • Food Chem.2019, 276:768-775
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • The Malaysian journal of pathology2019, 41(3):243-251
  • Front Microbiol.2020, 11:583594.
  • Int J Biol Macromol.2020, 161:1230-1239.
  • J Ethnopharmacol.2020, 269:113752.
  • Plant Sci.2020, 301:110656.
  • Medicina (Kaunas).2020, 56(12):685.
  • Horticulturae2020, 6(4),76.
  • Phytochemistry.2021, 181:112539.
  • Molecules.2021, 26(2):E255.
  • ...
  • 生物活性
    Description: Pinoresinol is the precursor of other dietary lignans that are present in whole-grain cereals, legumes, fruits, and other vegetables, PIN can cause an upregulation of the CDK inhibitor p21(WAF1/Cip1) both at mRNA and protein levels; PIN can ameliorate CCl4-induced acute liver injury, and this protection is likely due to anti-oxidative activity and down-regulation of inflammatory mediators through inhibition of NF-kappaB and AP-1. (+)-Pinoresinol possesses fungicidal activities and therapeutic potential as an antifungal agent for the treatment of fungal infectious diseases in humans.
    Targets: TNF-α | COX | NF-kB | NOS | AP-1 | JNK | CDK | p21
    In vitro:
    Molecules, 2010, 15(5):3507-16.
    Antifungal effect of (+)-pinoresinol isolated from Sambucus williamsii.[Pubmed: 20657496]

    METHODS AND RESULTS:
    In this study, we investigated the antifungal activity and mechanism of action of (+)-pinoresinol, a biphenolic compound isolated from the herb Sambucus williamsii,used in traditional medicine. (+)-Pinoresinol displays potent antifungal properties without hemolytic effects on human erythrocytes. To understand the antifungal mechanism of (+)-pinoresinol, we conducted fluorescence experiments on the human pathogen Candida albicans. Fluorescence analysis using 1,6-diphenyl-1,3,5-hexatriene (DPH) indicated that the (+)-pinoresinol caused damage to the fungal plasma membrane. This result was confirmed by using rhodamine-labeled giant unilamellar vesicle (GUV) experiments.
    CONCLUSIONS:
    Therefore, the present study indicates that (+)-pinoresinol possesses fungicidal activities and therapeutic potential as an antifungal agent for the treatment of fungal infectious diseases in humans.
    In vivo:
    J. Pharmacol. Sci. 2010,112(1):105-12.
    Hepatoprotective effect of pinoresinol on carbon tetrachloride-induced hepatic damage in mice.[Pubmed: 20093790]
    Forsythiae Fructus is known to have diuretic, anti-bacterial, and anti-inflammatory activities. This study examined the hepatoprotective effects of pinoresinol, a lignan isolated from Forsythiae Fructus, against carbon tetrachloride (CCl(4))-induced liver injury.
    METHODS AND RESULTS:
    Mice were treated intraperitoneally with vehicle or pinoresinol (25, 50, 100, and 200 mg/kg) 30 min before and 2 h after CCl4 (20 microl/kg) injection. In the vehicle-treated CCl(4 )group, serum aminotransferase activities were significantly increased 24 h after CCl4 injection, and these increases were attenuated by pinoresinol at all doses. Hepatic glutathione contents were significantly decreased and lipid peroxidation was increased after CCl4 treatment. These changes were attenuated by 50 and 100 mg/kg of pinoresinol. The levels of protein and mRNA expression of inflammatory mediators, including tumor necrosis factor-alpha, inducible nitric oxide synthase, and cyclooxygenase-2, were significantly increased after CCl4 injection; and these increases were attenuated by pinoresinol. Nuclear translocation of nuclear factor-kappaB (NF-kappaB) and phosphorylation of c-Jun, one of the components of activating protein 1 (AP-1), were inhibited by pinoresinol.
    CONCLUSIONS:
    Our results suggest that pinoresinol ameliorates CCl4)-induced acute liver injury, and this protection is likely due to anti-oxidative activity and down-regulation of inflammatory mediators through inhibition of NF-kappaB and AP-1.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7902 mL 13.9509 mL 27.9018 mL 55.8036 mL 69.7545 mL
    5 mM 0.558 mL 2.7902 mL 5.5804 mL 11.1607 mL 13.9509 mL
    10 mM 0.279 mL 1.3951 mL 2.7902 mL 5.5804 mL 6.9754 mL
    50 mM 0.0558 mL 0.279 mL 0.558 mL 1.1161 mL 1.3951 mL
    100 mM 0.0279 mL 0.1395 mL 0.279 mL 0.558 mL 0.6975 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (-)-表松脂酚; (-)-Epipinoresinol CFN92420 10061-38-8 C20H22O6 = 358.4 5mg QQ客服:2159513211
    连翘脂素; Phillygenin CFN90511 487-39-8 C21H24O6 = 372.41 20mg QQ客服:1413575084
    连翘苷; Phillyrin CFN99998 487-41-2 C27H34O11 = 534.56 20mg QQ客服:1413575084
    辛夷脂素; Fargesin CFN98174 31008-19-2 C21H22O6 = 370.39 20mg QQ客服:2159513211
    细辛脂素; Asarinin CFN90628 133-05-1 C20H18O6 = 354.35 20mg QQ客服:1457312923
    刺五加苷D; Eleutheroside D CFN98510 79484-75-6 C34H46O18 = 742.72 10mg QQ客服:1457312923
    刺五加苷 E; Eleutheroside E CFN99984 39432-56-9 C34H46O18 = 742.73 20mg QQ客服:1457312923
    (-)-松脂醇; (-)-Pinoresinol CFN92287 81446-29-9 C20H22O6 = 358.4 5mg QQ客服:1413575084
    (-)-丁香树脂酚; (-)-Syringaresinol CFN92500 6216-81-5 C22H26O8 = 418.4 5mg QQ客服:2159513211
    Hedyotisol A; Hedyotisol A CFN97537 95732-59-5 C42H50O16 = 810.9 5mg QQ客服:2932563308

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