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  • Periglaucine A

    Periglaucine A

    Periglaucine A
    产品编号 CFN99040
    CAS编号 1025023-04-4
    分子式 = 分子量 C20H23NO6 = 373.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The aerial parts of Pericampylus glaucus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Periglaucine A CFN99040 1025023-04-4 1mg QQ客服:3257982914
    Periglaucine A CFN99040 1025023-04-4 5mg QQ客服:3257982914
    Periglaucine A CFN99040 1025023-04-4 10mg QQ客服:3257982914
    Periglaucine A CFN99040 1025023-04-4 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Instituto Politécnico de Bragan?a (Portugal)
  • Colorado State University (USA)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Universidade da Beira Interior (Germany)
  • Weizmann Institute of Science (Israel)
  • Universidade Federal de Goias (UFG) (Brazil)
  • University of Wisconsin-Madison (USA)
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  • Uniwersytet Jagielloński w Krakowie (Poland)
  • St. Jude Children Research Hospital (USA)
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  • Chang Gung University (Taiwan)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Fitoterapia.2015, 100:179-86
  • J Breast Cancer.2015, 18(2):112-118
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • SBRAS2016, 12
  • Chemistr of plant2016, 2016021195
  • Nat Prod Commun.2017, 12(5):771-778
  • Org Biomol Chem.2017, 15(31):6483-6492
  • J Ethnopharmacol.2017, 206:327-336
  • Korean j.of Pharm.2017, 70-76
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • Evid Based Complement Alternat Med.2018, 2018:4580627
  • J Cell Mol Med.2018, 22(9):4236-4242
  • Molecules.2018, 23(2)
  • Nat Prod Sci.2018, 24(3):206
  • Food Chem.2018, 252:207-214
  • Cell Death Dis.2019, 10(12):882
  • Drug Invention Today2019, 12(6):1303-1306
  • Kor. J. Herbol.2019, 34(2):59-66
  • Int J Mol Med.2019, 43(6):2516-2522
  • J Asian Nat Prod Res.2019, 5:1-17
  • Journal of Functional Foods2019, 52:430-441
  • Nutrients2020, 12(2):488
  • Pharmacological Reports2020, 1-9
  • ...
  • 生物活性
    Description: Periglaucine A inhibits hepatitis B virus (HBV) surface antigen (HBsAg) secretion in Hep G2.2.15 cells.
    Targets: HBV
    In vitro:
    J Nat Prod. 2008 May;71(5):760-3.
    Periglaucines A-D, anti-HBV and -HIV-1 alkaloids from Pericampylus glaucus.[Pubmed: 18396905]

    METHODS AND RESULTS:
    Four new hasubanane-type alkaloids, periglaucines A-D (1-4), and three known alkaloids, norruffscine (5), (-)-8-oxotetrahydropalmatine (6), and (-)-8-oxocanadine (7), were isolated from the aerial parts of Pericampylus glaucus. Their structures were elucidated on the basis of extensive NMR and EIMS data, and that of periglaucine A (1) was confirmed by single-crystal X-ray diffraction.
    CONCLUSIONS:
    Alkaloids 1-4 inhibited hepatitis B virus (HBV) surface antigen (HBsAg) secretion in Hep G2.2.15 cells. (-)-8-Oxotetrahydropalmatine (6) possessed a high selectivity index (SI = 22.4) for HBsAg secretion of the Hep G2.2.15 cell line with an IC(50) value of 0.14 mM. Norruffscine (5) and (-)-8-oxotetrahydropalmatine (6) exhibited inhibitory activity against human immunodeficiency virus (HIV-1) with EC(50) values of 10.9 and 14.1 microM in C8166 cells (SI = 45.7 and 18.8), respectively.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6781 mL 13.3905 mL 26.7809 mL 53.5619 mL 66.9523 mL
    5 mM 0.5356 mL 2.6781 mL 5.3562 mL 10.7124 mL 13.3905 mL
    10 mM 0.2678 mL 1.339 mL 2.6781 mL 5.3562 mL 6.6952 mL
    50 mM 0.0536 mL 0.2678 mL 0.5356 mL 1.0712 mL 1.339 mL
    100 mM 0.0268 mL 0.1339 mL 0.2678 mL 0.5356 mL 0.6695 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    表千金藤默星碱; Epistephamiersine CFN98856 52389-15-8 C21H27NO6 = 389.5 5mg QQ客服:215959384
    Periglaucine A; Periglaucine A CFN99040 1025023-04-4 C20H23NO6 = 373.4 5mg QQ客服:3257982914
    细圆藤碱 B; Periglaucine B CFN96748 1025023-05-5 C20H23NO6 = 373.40 5mg QQ客服:1148253675
    青藤碱; Sinomenine CFN99508 115-53-7 C19H23NO4 = 329.38 20mg QQ客服:215959384
    盐酸青藤碱; Sinomenine HCl CFN99561 6080-33-7 C19H23NO4.HCl = 365.85 20mg QQ客服:2159513211
    粉防己G; Fenfangjine G CFN92332 205533-81-9 C22H27NO8 = 433.5 5mg QQ客服:3257982914
    16-氧代原间千金藤碱; 16-Oxoprometaphanine CFN98993 58738-31-1 C20H23NO6 = 373.4 5mg QQ客服:1413575084
    原间千金藤碱; Prometaphanine CFN97167 6858-85-1 C20H25NO5 = 359.4 5mg QQ客服:215959384
    原千金藤那布任碱; Prostephanaberrine CFN97858 105608-27-3 C19H21NO5 = 343.38 5mg QQ客服:1413575084
    清风藤碱; Sinoacutine CFN98640 4090-18-0 C19H21NO4 = 327.4 5mg QQ客服:2159513211

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