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  • 氧化血根碱

    Oxysanguinarine

    氧化血根碱
    产品编号 CFN91002
    CAS编号 548-30-1
    分子式 = 分子量 C20H13NO5 = 347.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Stephania epigaea
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    氧化血根碱 CFN91002 548-30-1 1mg QQ客服:215959384
    氧化血根碱 CFN91002 548-30-1 5mg QQ客服:215959384
    氧化血根碱 CFN91002 548-30-1 10mg QQ客服:215959384
    氧化血根碱 CFN91002 548-30-1 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • National Research Council of Canada (Canada)
  • Universidad de La Salle (Mexico)
  • Universidade do Porto (Portugal)
  • University of Virginia (USA)
  • University of Canterbury (New Zealand)
  • Pennsylvania State University (USA)
  • Universidade de Franca (Brazil)
  • Lodz University of Technology (Poland)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Mahatma Gandhi University (India)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Universidad de Antioquia (Colombia)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Harvard University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antiviral Res.2013, 98(3):386-93
  • Ind Crops Prod.2014, 62:173-178
  • Food Research International2016, 106-113
  • Jour. of Stored Pro & Postharvest Res.2016, 7(3):32-36
  • Phytochemistry.2017, 141:162-170
  • Neuropharmacology.2018, 131:68-82
  • Int J Mol Sci.2018, 19(9):E2528
  • Korean Journal of Medicinal Crop Science2018, 26(5):382-390
  • Phytother Res.2018, 32(12):2551-2559
  • Anticancer Res.2018, 38(4):2127-2135
  • J Liq Chromatogr R T2018, 41(12):761-769
  • Pharmacol Rep.2018, 70(6):1195-1201
  • Sci Rep.2018, 8(1):12970
  • Virulence.2018, 9(1):588-603
  • Front Immunol.2018, 9:2091
  • Pharmacognosy Journal2019, 11(2): 369-373
  • Nutrients.2019, 11(6):E1380
  • Front Aging Neurosci.2019, 11:230
  • Int J Biol Macromol.2019, 126:653-661
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • Anal Biochem.2019, 569:10-15
  • Food Sci Nutr.2019, 8(1):246-256
  • Appl. Sci.2020, 10,1304
  • ...
  • 生物活性
    Description: Oxysanguinarine possesses antiplatelet aggregation activity, it has potential inhibitory properties against dengue virus.
    Targets: Antifection
    In vitro:
    J Vector Borne Dis. 2017 Jul-Sep;54(3):255-262.
    Computer-aided analysis of phytochemicals as potential dengue virus inhibitors based on molecular docking, ADMET and DFT studies.[Pubmed: 29097641]
    Dengue fever, caused by dengue virus (DENV), has become a serious threat to human lives. Phytochemicals are known to have great potential to eradicate viral, bacterial and fungal-borne diseases in human beings. This study was aimed at in silico drug development against nonstructural protein 4B (NS4B) of dengue virus 4 (DENV4).
    METHODS AND RESULTS:
    A total of 2750 phytochemicals from different medicinal plants were selected for this study. These plants grow naturally in the climate of Pakistan and India and have been used for the treatment of various pathologies in human for long-time. The ADMET studies, molecular docking and density functional theory (DFT) based analysis were carried out to determine the potential inhibitory properties of these phytochemicals. The ADMET analysis and docking results revealed nine phytochemicals, i.e. Silymarin, Flavobion, Derrisin, Isosilybin, Mundulinol, Silydianin, Isopomiferin, Narlumicine and Oxysanguinarine to have potential inhibitory properties against DENV and can be considered for additional in vitro and in vivo studies to assess their inhibitory effects against DENV replication. They exhibited binding affinity ≥ -8 kcal/mol against DENV4-NS4B. Furthermore, DFT based analysis revealed high reactivity for these nine phytochemicals in the binding pocket of DENV4-NS4B, based on ELUMO, EHOMO and band energy gap. INTERPRETATION &
    CONCLUSIONS:
    Five out of nine phytochemicals are reported for the first time as novel DENV inhibitors. These included three phytochemicals from Silybum marianum, i.e. Derrisin, Mundulinol, Isopomiferin, and two phytochemicals from Fumaria indica, i.e. Narlumicine and Oxysanguinarine. However, all the nine phytochemicals can be considered for in vitro and in vivo analysis for the development of potential DENV inhibitors.
    Planta Med. 1999 Oct;65(7):643-7.
    New tetrahydroprotoberberine N-oxide alkaloids and cytotoxic constituents of Corydalis tashiroi.[Pubmed: 17260290 ]

    METHODS AND RESULTS:
    Three new tetrahydroprotoberberine N-oxide alkaloids, (-)- cis-corydalmine N-oxide, (-)- trans-corydalmine N-oxide, and (-)- trans-isocorypalmine N-oxide, along with three known benzo[ C]phenanthridine alkaloids, norsanguinarine, dihydrosanguinarine, and oxysanguinarine, six known berberine alkaloids, (-)-tetrahydropalmatine, (-)-corydalmine, (-)-scoulerine, (-)-corynoxidine, (-)-epicorynoxidine, palmatine, and protopine, have been isolated from the herb Corydalis tashiroi.
    CONCLUSIONS:
    The structures of these compounds were elucidated by spectroscopic analysis. Three of the isolated compounds show significant cytotoxic activities (ED (50) values < 4 microg/ml) against P-388, KB16, A549, and HT-29 cell lines.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8794 mL 14.3968 mL 28.7936 mL 57.5871 mL 71.9839 mL
    5 mM 0.5759 mL 2.8794 mL 5.7587 mL 11.5174 mL 14.3968 mL
    10 mM 0.2879 mL 1.4397 mL 2.8794 mL 5.7587 mL 7.1984 mL
    50 mM 0.0576 mL 0.2879 mL 0.5759 mL 1.1517 mL 1.4397 mL
    100 mM 0.0288 mL 0.144 mL 0.2879 mL 0.5759 mL 0.7198 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    乙酰紫堇灵; Acetylcorynoline CFN99749 18797-80-3 C23H23NO6 = 409.43 20mg QQ客服:3257982914
    白屈菜碱; Chelidonine CFN90319 476-32-4 C20H19NO5 = 353.37 20mg QQ客服:2932563308
    二氢白屈菜红碱; Dihydrochelerythrine CFN90127 6880-91-7 C21H19NO4 = 349.38 10mg QQ客服:2932563308
    去甲白屈菜红碱; Norchelerythrine CFN92737 6900-99-8 C20H15NO4 = 333.3 5mg QQ客服:2932563308
    氧基白屈菜季铵碱; Oxychelerythrine CFN97999 28342-33-8 C21H17NO5 = 363.4 5mg QQ客服:2932563308
    德卡林碱; Decarine CFN98909 54354-62-0 C19H13NO4 = 319.3 5mg QQ客服:1148253675
    氯化两面针碱; Nitidine chloride CFN98109 13063-04-2 C21H18ClNO4 = 383.83 20mg QQ客服:3257982914
    血根碱; Sanguinarine CFN98259 2447-54-3 C20H14NO4 = 332.3 20mg QQ客服:2932563308
    二氢血根碱; Dihydrosanguinarine CFN92810 3606-45-9 C20H15NO4 = 333.1 10mg QQ客服:2159513211
    6-Methoxydihydrosanguinarine; 6-Methoxydihydrosanguinarine CFN89299 72401-54-8 C21H17NO5 = 363.36 5mg QQ客服:215959384

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