二氢白屈菜红碱
Dihydrochelerythrine
产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
二氢白屈菜红碱 |
CFN90127 |
6880-91-7 |
10mg |
QQ客服:2159513211 |
二氢白屈菜红碱 |
CFN90127 |
6880-91-7 |
20mg |
QQ客服:2159513211 |
二氢白屈菜红碱 |
CFN90127 |
6880-91-7 |
50mg |
QQ客服:2159513211 |
二氢白屈菜红碱 |
CFN90127 |
6880-91-7 |
100mg |
QQ客服:2159513211 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
Macau University of Science and Technology (China)
CSIRO - Agriculture Flagship (Australia)
Korea Intitute of Science and Technology (KIST) (Korea)
VIT University (India)
University of Minnesota (USA)
The Institute of Cancer Research (United Kingdom)
Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
University of Sao Paulo (Brazil)
Shanghai Institute of Organic Chemistry (China)
National Chung Hsing University (Taiwan)
University of Auckland (New Zealand)
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
Sanford Burnham Prebys Medical Discovery Institute (USA)
Monash University (Australia)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
Description: |
Dihydrochelerythrine has antifungal activity against pathogenic plant fungi; it shows antiparasitic efficacy against Ichthyophthirius multifiliis in richadsin, it has potential application in the therapy of serious infection caused by I. multifiliis. Dihydrochelerythrine affects cell cycle distribution, activates mitochondrial apoptotic pathway, and induces apoptosis and necrosis in HL-60 cells. |
Targets: |
Antifection | Caspase |
In vitro: |
Nat Prod Res. 2011 Jul;25(11):1082-9. | Inhibitory activity of dihydrosanguinarine and dihydrochelerythrine against phytopathogenic fungi.[Pubmed: 21500094] | The antifungal activities of dihydrosanguinarine and dihydrochelerythrine, isolated from the leaves of Macleaya microcarpa, were evaluated on 12 plant pathogenic fungi; the two compounds exhibited the highest antifungal activity against Botrytis cinerea Pers.
METHODS AND RESULTS:
Among the 11 tested plant pathogenic fungi in vitro, the two compounds showed the highest antifungal activity against B. cinerea Pers, with 95.16% and 98.32% mycelial growth inhibition at 50 μg mL⁻1, respectively. In addition, the two compounds inhibited spore germination in vitro in a concentration-dependent manner. They also showed potent protective and curative effects against Erysiphe graminis and B. cinerea in vivo.
CONCLUSIONS:
This is the first report on the antifungal activity of dihydrosanguinarine and dihydrochelerythrine against pathogenic plant fungi. |
|
In vivo: |
Vet Parasitol. 2011 Dec 29;183(1-2):8-13. | Antiparasitic efficacy of dihydrosanguinarine and dihydrochelerythrine from Macleaya microcarpa against Ichthyophthirius multifiliis in richadsin (Squaliobarbus curriculus).[Pubmed: 21813242] | Ichthyophthirius multifiliis is a holotrichous protozoan that invades the gills and skin surfaces of fish and can cause morbidity and high mortality in most species of freshwater fish worldwide.
The present study was undertaken to investigate the antiparasitic activity of crude extracts and pure compounds from the leaves of Macleaya microcarpa.
METHODS AND RESULTS:
The chloroform extract showed a promising antiparasitic activity against I. multifiliis. Based on these finding, the chloroform extract was fractionated on silica gel column chromatography in a bioactivity-guided isolation affording two compounds showing potent activity. The structures of the two compounds were elucidated as dihydrosanguinarine and dihydrochelerythrine by hydrogen and carbon-13 nuclear magnetic resonance spectrum and electron ionization mass spectrometry. The in vivo tests revealed that dihydrosanguinarine and dihydrochelerythrine were effective against I. multifiliis with median effective concentration (EC(50)) values of 5.18 and 9.43 mg/l, respectively. The acute toxicities (LC(50)) of dihydrosanguinarine and dihydrochelerythrine for richadsin were 13.3 and 18.2mg/l, respectively.
CONCLUSIONS:
The overall results provided important information for the potential application of dihydrosanguinarine and dihydrochelerythrine in the therapy of serious infection caused by I. multifiliis. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
2.8622 mL |
14.3111 mL |
28.6221 mL |
57.2443 mL |
71.5553 mL |
5 mM |
0.5724 mL |
2.8622 mL |
5.7244 mL |
11.4489 mL |
14.3111 mL |
10 mM |
0.2862 mL |
1.4311 mL |
2.8622 mL |
5.7244 mL |
7.1555 mL |
50 mM |
0.0572 mL |
0.2862 mL |
0.5724 mL |
1.1449 mL |
1.4311 mL |
100 mM |
0.0286 mL |
0.1431 mL |
0.2862 mL |
0.5724 mL |
0.7156 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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