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  • 二氢白屈菜红碱

    Dihydrochelerythrine

    二氢白屈菜红碱
    产品编号 CFN90127
    CAS编号 6880-91-7
    分子式 = 分子量 C21H19NO4 = 349.38
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Chelidonium majus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    二氢白屈菜红碱 CFN90127 6880-91-7 10mg QQ客服:2159513211
    二氢白屈菜红碱 CFN90127 6880-91-7 20mg QQ客服:2159513211
    二氢白屈菜红碱 CFN90127 6880-91-7 50mg QQ客服:2159513211
    二氢白屈菜红碱 CFN90127 6880-91-7 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Macau University of Science and Technology (China)
  • CSIRO - Agriculture Flagship (Australia)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • VIT University (India)
  • University of Minnesota (USA)
  • The Institute of Cancer Research (United Kingdom)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • University of Sao Paulo (Brazil)
  • Shanghai Institute of Organic Chemistry (China)
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  • University of Auckland (New Zealand)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Monash University (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Neuroinflammation.2020, 17(1):75.
  • Biochemistry.2018, 57(40):5886-5896
  • Cancer Lett. 2023, 18:216584.
  • Nutrients.2017, 10(1)
  • Agriculture.2022, 12(3), 342.
  • Biomedicine & Pharmacotherapy2020, 125:109950
  • Oncotarget.2017, 8(53):90925-90947
  • J of Ana. Chem.2019, 74(11):1113-1121
  • South African J of Botany2020, 135:50-57
  • Life (Basel).2022, 12(10):1630.
  • Oxid Med Cell Longev.2020, 2020:8887251.
  • JABS2020, 14:2(2020)
  • Antioxidants (Basel).2021, 10(11): 1802.
  • Planta Med.2018, 84(15):1101-1109
  • Biomolecules.2021, 11(10):1537.
  • Food Funct.2021, 12(13):5892-5902.
  • Bulletin of Health Research2016, 44(4):279-286
  • Acta Edulis Fungi2020, 27(02):63-76.
  • Antioxidants (Basel).2022, 11(12):2496.
  • Exp Biol Med (Maywood).2019, 244(18):1665-1679
  • J Cell Mol Med.2023, 27(10):1423-1435.
  • J Pharmacol Sci.2021, 147(2):184-191.
  • J Appl Biol Chem2022, 65:343−348.
  • ...
  • 生物活性
    Description: Dihydrochelerythrine has antifungal activity against pathogenic plant fungi; it shows antiparasitic efficacy against Ichthyophthirius multifiliis in richadsin, it has potential application in the therapy of serious infection caused by I. multifiliis. Dihydrochelerythrine affects cell cycle distribution, activates mitochondrial apoptotic pathway, and induces apoptosis and necrosis in HL-60 cells.
    Targets: Antifection | Caspase
    In vitro:
    Nat Prod Res. 2011 Jul;25(11):1082-9.
    Inhibitory activity of dihydrosanguinarine and dihydrochelerythrine against phytopathogenic fungi.[Pubmed: 21500094]
    The antifungal activities of dihydrosanguinarine and dihydrochelerythrine, isolated from the leaves of Macleaya microcarpa, were evaluated on 12 plant pathogenic fungi; the two compounds exhibited the highest antifungal activity against Botrytis cinerea Pers.
    METHODS AND RESULTS:
    Among the 11 tested plant pathogenic fungi in vitro, the two compounds showed the highest antifungal activity against B. cinerea Pers, with 95.16% and 98.32% mycelial growth inhibition at 50 μg mL⁻1, respectively. In addition, the two compounds inhibited spore germination in vitro in a concentration-dependent manner. They also showed potent protective and curative effects against Erysiphe graminis and B. cinerea in vivo.
    CONCLUSIONS:
    This is the first report on the antifungal activity of dihydrosanguinarine and dihydrochelerythrine against pathogenic plant fungi.
    In vivo:
    Vet Parasitol. 2011 Dec 29;183(1-2):8-13.
    Antiparasitic efficacy of dihydrosanguinarine and dihydrochelerythrine from Macleaya microcarpa against Ichthyophthirius multifiliis in richadsin (Squaliobarbus curriculus).[Pubmed: 21813242]
    Ichthyophthirius multifiliis is a holotrichous protozoan that invades the gills and skin surfaces of fish and can cause morbidity and high mortality in most species of freshwater fish worldwide. The present study was undertaken to investigate the antiparasitic activity of crude extracts and pure compounds from the leaves of Macleaya microcarpa.
    METHODS AND RESULTS:
    The chloroform extract showed a promising antiparasitic activity against I. multifiliis. Based on these finding, the chloroform extract was fractionated on silica gel column chromatography in a bioactivity-guided isolation affording two compounds showing potent activity. The structures of the two compounds were elucidated as dihydrosanguinarine and dihydrochelerythrine by hydrogen and carbon-13 nuclear magnetic resonance spectrum and electron ionization mass spectrometry. The in vivo tests revealed that dihydrosanguinarine and dihydrochelerythrine were effective against I. multifiliis with median effective concentration (EC(50)) values of 5.18 and 9.43 mg/l, respectively. The acute toxicities (LC(50)) of dihydrosanguinarine and dihydrochelerythrine for richadsin were 13.3 and 18.2mg/l, respectively.
    CONCLUSIONS:
    The overall results provided important information for the potential application of dihydrosanguinarine and dihydrochelerythrine in the therapy of serious infection caused by I. multifiliis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8622 mL 14.3111 mL 28.6221 mL 57.2443 mL 71.5553 mL
    5 mM 0.5724 mL 2.8622 mL 5.7244 mL 11.4489 mL 14.3111 mL
    10 mM 0.2862 mL 1.4311 mL 2.8622 mL 5.7244 mL 7.1555 mL
    50 mM 0.0572 mL 0.2862 mL 0.5724 mL 1.1449 mL 1.4311 mL
    100 mM 0.0286 mL 0.1431 mL 0.2862 mL 0.5724 mL 0.7156 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    bis[6-(5,6-dihydrochelerythrinyl)]amine; bis[6-(5,6-dihydrochelerythrinyl)]amine CFN91015 165393-48-6 C42H37N3O8 = 711.76 5mg QQ客服:3257982914
    乙酰紫堇灵; Acetylcorynoline CFN99749 18797-80-3 C23H23NO6 = 409.43 20mg QQ客服:2056216494
    白屈菜碱; Chelidonine CFN90319 476-32-4 C20H19NO5 = 353.37 20mg QQ客服:3257982914
    二氢白屈菜红碱; Dihydrochelerythrine CFN90127 6880-91-7 C21H19NO4 = 349.38 20mg QQ客服:1413575084
    去甲白屈菜红碱; Norchelerythrine CFN92737 6900-99-8 C20H15NO4 = 333.3 5mg QQ客服:215959384
    氧基白屈菜季铵碱; Oxychelerythrine CFN97999 28342-33-8 C21H17NO5 = 363.4 5mg QQ客服:1413575084
    德卡林碱; Decarine CFN98909 54354-62-0 C19H13NO4 = 319.3 5mg QQ客服:2159513211
    氯化两面针碱; Nitidine chloride CFN98109 13063-04-2 C21H18ClNO4 = 383.83 20mg QQ客服:2159513211
    血根碱; Sanguinarine CFN98259 2447-54-3 C20H14NO4 = 332.3 20mg QQ客服:215959384
    二氢血根碱; Dihydrosanguinarine CFN92810 3606-45-9 C20H15NO4 = 333.1 20mg QQ客服:1413575084

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