Oleuropeic acid

	产品编号	CFN98795
	CAS编号	5027-76-9
	分子式 = 分子量	C₁₀H₁₆O₃ = 184.2
	产品纯度	>=98%
	物理属性	Oil
	化合物类型	Monoterpenoids
	植物来源	The leaves of Eucalyptus maideni
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Oleuropeic acid	CFN98795	5027-76-9	1mg	QQ客服：215959384
Oleuropeic acid	CFN98795	5027-76-9	5mg	QQ客服：215959384
Oleuropeic acid	CFN98795	5027-76-9	10mg	QQ客服：215959384
Oleuropeic acid	CFN98795	5027-76-9	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Canterbury (New Zealand)

Charles University in Prague (Czech Republic)

Wageningen University (Netherlands)

Uniwersytet Jagielloński w Krakowie (Poland)

Calcutta University (India)

Utah State University (USA)

Aveiro University (Portugal)

University of Helsinki (Finland)

Worcester Polytechnic Institute (USA)

Sant Gadge Baba Amravati University (India)

Center for protein Engineering (CIP) (Belgium)

University of Beira Interior (Portugal)

Research Unit Molecular Epigenetics (MEG) (Germany)

Univerzita Karlova v Praze (Czech Republic)

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Description:

(+)-Oleuropeic acid shows potent in vitro antitumor-promoting activity, it also suppresses an in vivo two-stage carcinogenesis induced with nitric oxide and 12-O-tetradecanoyl phorbol 13-acetate (TPA) on mouse skin.

In vitro:

J Agric Food Chem. 2014 Jan 8;62(1):144-51.

Radical-scavenging compounds from olive tree (Olea europaea L.) wood.[Pubmed: 24328093]

The purpose of this study was to complete knowledge on the chemical composition and radical-scavenging activity of olive tree wood.
METHODS AND RESULTS:
Two new monoterpene glycosides, (-)-Oleuropeic acid 6'-O-α-D-glucopyranosyl ester (6a) and (-)-perillic acid 1'-O-β-D-primeverosyl ester (8), together with the known compounds (-)-Oleuropeic acid (1), (-)-olivil (2), the aldehydic form of oleuropein aglycone (3), (+)-1-hydroxypinoresinol 1-O-β-D-glucopyranoside (4), (-)-Oleuropeic acid 1'-O-β-D-glucopyranosyl ester (5), (-)-Oleuropeic acid 6'-O-β-D-glucopyranosyl ester (6b), and (-)-olivil 4-O-β-D-glucopyranoside (7) were isolated from an ethyl acetate extract. The radical scavengers found (2-4 and 7) were detected and isolated with the help of the online HPLC-DAD-DPPH/ABTS technique.
CONCLUSIONS:
Compounds 2-4 and 7 displayed a higher antioxidative effect against the free radical DPPH than the reference BHT and lower than hydroxytyrosol, whereas compounds 1, 5, 6a, 6b, and 8 showed no activity.

In vivo:

J Nat Prod. 2000 Sep;63(9):1253-7.

Cypellocarpins A-C, phenol glycosides esterified with oleuropeic acid, from Eucalyptus cypellocarpa.[Pubmed: 11000030]

METHODS AND RESULTS:
Three new phenol glycosides acylated with (+)-Oleuropeic acid, cypellocarpins A (1), B (2), and C (3), along with seven known compounds, were isolated from the dried leaves of Eucalyptus cypellocarpa. Structures of the new compounds were determined on the basis of spectroscopic methods, including 2D NMR experiments and chemical degradation. These new compounds and a known related glucoside (7) showed potent in vitro antitumor-promoting activity in a short-term bioassay evaluating the inhibitory effect on Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoyl phorbol 13-acetate (TPA).
CONCLUSIONS:
These compounds also suppressed an in vivo two-stage carcinogenesis induced with nitric oxide and TPA on mouse skin.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
2-羟基-1,8-桉树脑; 2-Hydroxy-1,8-cineole	CFN97032	60761-00-4	C₁₀H₁₈O₂ = 170.3	5mg	QQ客服：1413575084
alpha-松油醇; Terpineol	CFN92688	98-55-5	C₁₀H₁₈O = 154.3	20mg	QQ客服：2159513211
α-松油醇; Alpha-Terpineol	CFN80110	10482-56-1	C₁₀H₁₈O = 154.25	5mg	QQ客服：215959384
4-萜烯醇; Terpinine-4-ol	CFN94877	562-74-3	C₁₀H₁₈O = 154.3	50mg	QQ客服：2056216494
对薄荷烷-1,2,8-三醇; p-Menthane-1,2,8-triol	CFN97064	62014-81-7	C₁₀H₂₀O₃ = 188.3	5mg	QQ客服：1413575084
对萜品-1,3,8-三醇; p-Menthane-1,3,8-triol	CFN99656	155348-06-4	C₁₀H₂₀O₃ = 188.3	5mg	QQ客服：2159513211
Oleuropeic acid; Oleuropeic acid	CFN98795	5027-76-9	C₁₀H₁₆O₃ = 184.2	5mg	QQ客服：3257982914
L-紫苏醇; Perillyl alcohol	CFN93581	536-59-4	C₁₀H₁₆O = 152.2	20mg	QQ客服：215959384
橄榄苦苷酸 8-O-葡萄糖苷; Oleuropeic acid 8-O-glucoside	CFN96125	865887-46-3	C₁₆H₂₆O₈ = 346.4	5mg	QQ客服：2056216494
Cuniloside B; Cuniloside B	CFN99285	1187303-40-7	C₂₆H₄₀O₁₀ = 512.6	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.4289 mL	27.1444 mL	54.2888 mL	108.5776 mL	135.722 mL
5 mM	1.0858 mL	5.4289 mL	10.8578 mL	21.7155 mL	27.1444 mL
10 mM	0.5429 mL	2.7144 mL	5.4289 mL	10.8578 mL	13.5722 mL
50 mM	0.1086 mL	0.5429 mL	1.0858 mL	2.1716 mL	2.7144 mL
100 mM	0.0543 mL	0.2714 mL	0.5429 mL	1.0858 mL	1.3572 mL