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  • 三七皂苷R4

    Notoginsenoside R4

    三七皂苷R4
    产品编号 CFN91142
    CAS编号 87741-77-3
    分子式 = 分子量 C59H100O27 = 1241.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots and rhizomes of Panax ginseng
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    三七皂苷R4 CFN91142 87741-77-3 1mg QQ客服:2932563308
    三七皂苷R4 CFN91142 87741-77-3 5mg QQ客服:2932563308
    三七皂苷R4 CFN91142 87741-77-3 10mg QQ客服:2932563308
    三七皂苷R4 CFN91142 87741-77-3 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Anticancer Res.2014, 34(7):3505-9
  • Mol Med Rep.2014, 9(5):1653-9
  • Molecules.2015, 20(11):20014-30
  • Plant Methods.2017, 13:108
  • Tropical J. of Pha. Research2017, 16(3):543-552
  • Aquaculture2017, 481:94-102
  • ACS Nano.2018, 12(4):3385-3396
  • Microchemical Journal2018, 137:168-173
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  • Front Cell Infect Microbiol.2018, 8:292
  • Eur J Pharmacol.2018, 832:96-103
  • Journal of Life Science2018, 917-922
  • Int J Biol Macromol.2019, 126:653-661
  • Industrial Crops and Products2019, 140:111612
  • Trop J Nat Prod Res.2019, 3(1):6-9
  • Anal Sci.2019, 35(12):1317-1325
  • J Sep Sci.2019, 42(21):3352-3362
  • Chemistry of Natural Compounds2019, 55(1):127-130
  • Biosci. Rep.2020, 10.1024
  • Food Funct.2020, 10.1039
  • Molecules.2020, 25(3):734
  • ...
  • 生物活性
    Description: Reference standards.
    In vitro:
    Planta Med. 2001 Jul;67(5):417-22.
    Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions.[Pubmed: 11488454 ]
    Gap junctions have been shown or are believed to be involved in the pathogenesis of many inherited and acquired human diseases. Agents that regulate the gap junction-mediated intercellular communication (GJIC) function may facilitate prevention and treatment of GJIC-involved diseases.
    METHODS AND RESULTS:
    In the present study we examined the effects of 27 ginsenosides isolated from Panax ginseng on GJIC. The results show that compounds 1 (oleanolic acid), 2 (ginsenoside-R0), 3 (ginsenoside-Rb1), 5 (ginsenoside-Rb2), 7 (ginsenoside-Rd), 8 (ginsenoside-Rg3), 12 (panaxadial), 13 (notoginsenoside R4), 17 [ginsenoside-Rg2 (20S)], 18 (ginsenoside-Rf), and 26 (ginsenoside-F3) did not obviously affect GJIC, whereas compounds 4 (ginsenoside-Rc), 6 (ginsenoside-Rb3), 9 (ginsenoside-Rd2), 10 (notoginsenoside-Fe), 11 (ginsenoside-Rh2),14 (ginsenoside-Ra1), 15 (ginsenoside-Re), 16 [ginsenoside-Rg2 (20R)], 19 (ginsenoside-Ia), 20 [ginsenoside-Rh1 (20S)], 21 [ginsenoside-Rh1 (20R)], 22 (ginsenoside-F1), 23 (protopanaxatriol), 24 (panaxatriol), 25 (ginsenoside-Rg1), and 27 (chikusetsaponin-L8) induced GJIC reductions at various degrees. Compounds 2, 7, and 8 protected against the tyrosine phosphatase inhibitor vanadate-induced GJIC reduction, while compounds 1, 5, 7, and 17 inhibited the cytokine interleukin 1 alpha (IL-1alpha)-induced reduction in GJIC. Nevertheless, no compounds protected against the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced GJIC inhibition. On the other hand, GJIC reductions induced by compounds 6, 9,10, 20, 21, 22, 24, and 25 were inhibited by the tyrosine kinase (TK) inhibitor genistein, while GJIC reductions induced by compounds 6, 9, 14, 16, 19, 21, and 24 were attenuated in the presence of the PKC inhibitor calphostin C. However, GJIC reductions induced by compounds 4, 23, and 27 were not inhibited either by genistein or by calphostin C.
    CONCLUSIONS:
    These data indicate that various mechanisms are responsible for effects of ginsenosides on GJIC.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.8055 mL 4.0277 mL 8.0554 mL 16.1108 mL 20.1386 mL
    5 mM 0.1611 mL 0.8055 mL 1.6111 mL 3.2222 mL 4.0277 mL
    10 mM 0.0806 mL 0.4028 mL 0.8055 mL 1.6111 mL 2.0139 mL
    50 mM 0.0161 mL 0.0806 mL 0.1611 mL 0.3222 mL 0.4028 mL
    100 mM 0.0081 mL 0.0403 mL 0.0806 mL 0.1611 mL 0.2014 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    三七皂苷R1; Notoginsenoside R1 CFN99999 80418-24-2 C47H80O18 = 933.13 20mg QQ客服:215959384
    人参皂苷Re; Ginsenoside Re CFN99974 52286-59-6 C48H82O18 = 947.15 20mg QQ客服:2932563308
    人参皂苷Rd; Ginsenoside Rd CFN99975 52705-93-8 C48H82O18 = 947.2 20mg QQ客服:1413575084
    七叶胆苷 XLVI; Gypenoside XLVI CFN93372 94705-70-1 C48H82O19 = 963.2 10mg QQ客服:215959384
    人参皂苷F4; Ginsenoside F4 CFN90757 181225-33-2 C42H70O12 = 767.0 10mg QQ客服:215959384
    人参皂苷MC; Ginsenoside MC CFN95232 175484-06-7 C41H70O12 = 755.0 10mg QQ客服:2159513211
    Gynosaponin I; Gynosaponin I CFN96182 1207861-69-5 C42H72O12 = 769.0 5mg QQ客服:3257982914
    人参皂苷F2; Ginsenoside F2 CFN99755 62025-49-4 C42H72O13 = 785.01 20mg QQ客服:1148253675
    人参皂苷Rd2; Ginsenoside Rd2 (Quinquenoside L10) CFN95231 83480-64-2 C47H80O17 = 917.2 10mg QQ客服:215959384
    七叶胆苷XVI; Gypenoside XVII CFN90193 80321-69-3 C48H82O18 = 947.16 20mg QQ客服:1148253675

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