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  • 人参皂苷F3

    Ginsenoside F3

    人参皂苷F3
    产品编号 CFN99978
    CAS编号 62025-50-7
    分子式 = 分子量 C41H70O13 = 770.99
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Triterpenoids
    植物来源 The roots of Panax ginseng C. A. Mey.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    人参皂苷F3 CFN99978 62025-50-7 1mg QQ客服:215959384
    人参皂苷F3 CFN99978 62025-50-7 5mg QQ客服:215959384
    人参皂苷F3 CFN99978 62025-50-7 10mg QQ客服:215959384
    人参皂苷F3 CFN99978 62025-50-7 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules. 2013, 18(7):7376-88
  • J Biol Chem.2014, 289(3):1723-31
  • J Agric Food Chem.2015, 63(44):9869-78
  • Mediators Inflamm. 2016, 2016:6189590
  • J Pharm Anal.2016, 6(6):363-373
  • Tropical J. of Pha. Research2017, 16(3):543-552
  • Int J Anal Chem.2017, 2017:1254721
  • Chin. Med.J.Res. Prac.2017, 31(4)
  • Front Aging Neurosci.2018, 10:269
  • Biol Pharm Bull.2018, 41(11):1645-1651
  • BMB Rep.2018, 51(5):249-254
  • J Agric Food Chem.2018, 66(1):351-358
  • Pharmacol Rep.2018, 70(6):1195-1201
  • Sci Rep.2018, 8:15059
  • Wageningen University & Research2018, January 2018
  • Int J Biol Macromol.2019, 126:653-661
  • Plant Physiol Biochem.2019, 144:355-364
  • Int J Mol Sci.2019, 20(21):E5488
  • Academic J of Second Military Medical University2019, 40(1)
  • Metabolites.2019, 9(11):E271
  • J Sep Sci.2020, 201901140
  • J Ethnopharmacol.2020, 249:112396
  • Molecules.2020, 25(3):734
  • ...
  • 生物活性
    Description: Ginsenoside F3 has immunoenhancing activity by regulating production and gene expression of type 1,type 2 cytokines in murine spleen cells. It enhances the NF-kappaB DNA binding activity induced by ConA in murine spleen cells with 10 micromol/L.
    Targets: NF-kB | IL Receptor | IFN-γ
    In vitro:
    Acta Pharmacol Sin. 2004 Dec;25(12):1671-6.
    Immunoenhancing activity of protopanaxatriol-type ginsenoside-F3 in murine spleen cells.[Pubmed: 15569414]
    To investigate the immunoenhancing activity of ginsenoside F3 in murine spleen cells and explore its mechanism.
    METHODS AND RESULTS:
    The enhancing effect of ginsenoside F3 on murine spleen cell proliferation was studied using [3H]thymidine incorporation assay. Effects of ginsenoside-F3 on the production of type 1 cytokines IL-2, IFN-gamma, and type 2 cytokines IL-4 and IL-10 from murine spleen cells were detected by ELISA method. Effects of ginsenoside F3 on mRNA level of cytokines IL-4, IFN-gamma, and transcription factors T-bet and GATA-3 were evaluated by RT-PCR analysis. Effect of ginsenoside F3 on NF-kappaB DNA binding activity in murine spleen cells was investigated by electrophoretic mobility shift assays (EMSA). ginsenoside F3 at 0.1-100 micromol/L not only promoted the murine spleen cell proliferation, but also increased the production of IL-2 and IFN-gamma, while decreased the production of IL-4 and IL-10 from murine spleen cells with the maximal effect at 10 micromol/L. RT-PCR analysis displayed that ginsenoside F3 enhanced the IFN-gamma and T-bet gene expression and decreased IL-4 and GATA-3 gene expression. EMSA experiment showed that ginsenoside F3 10 micromol/L enhanced the NF-kappaB DNA binding activity induced by ConA in murine spleen cells.
    CONCLUSIONS:
    ginsenoside F3 has immunoenhancing activity by regulating production and gene expression of type 1 cytokines and type 2 cytokines in murine spleen cells.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.297 mL 6.4852 mL 12.9703 mL 25.9407 mL 32.4258 mL
    5 mM 0.2594 mL 1.297 mL 2.5941 mL 5.1881 mL 6.4852 mL
    10 mM 0.1297 mL 0.6485 mL 1.297 mL 2.5941 mL 3.2426 mL
    50 mM 0.0259 mL 0.1297 mL 0.2594 mL 0.5188 mL 0.6485 mL
    100 mM 0.013 mL 0.0649 mL 0.1297 mL 0.2594 mL 0.3243 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    人参皂苷Rc; Ginsenoside Rc CFN99973 11021-14-0 C53H90O22 = 1079.27 20mg QQ客服:3257982914
    人参皂苷F1; Ginsenoside F1 CFN99754 53963-43-2 C36H62O9 = 638.88 20mg QQ客服:2932563308
    3-乙酰人参皂苷F1; 3-Acetyl-ginsenoside F1 CFN95238 N/A C38H64O10 = 680.9 5mg QQ客服:1413575084
    人参皂苷F3; Ginsenoside F3 CFN99978 62025-50-7 C41H70O13 = 770.99 10mg QQ客服:2932563308
    人参皂苷F5; Ginsenoside F5 CFN95034 189513-26-6 C41H70O13 = 771.0 20mg QQ客服:1148253675
    人参皂苷Rg1; Ginsenoside Rg1 CFN99967 22427-39-0 C42H72O14 = 801.01 20mg QQ客服:3257982914
    三七皂苷R1; Notoginsenoside R1 CFN99999 80418-24-2 C47H80O18 = 933.13 20mg QQ客服:1413575084
    人参皂苷Re; Ginsenoside Re CFN99974 52286-59-6 C48H82O18 = 947.15 20mg QQ客服:3257982914
    人参皂苷Rd; Ginsenoside Rd CFN99975 52705-93-8 C48H82O18 = 947.2 20mg QQ客服:2159513211
    七叶胆苷 XLVI; Gypenoside XLVI CFN93372 94705-70-1 C48H82O19 = 963.2 10mg QQ客服:2932563308

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