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  • 闹达柯裂亭

    Nodakenetin

    闹达柯裂亭
    产品编号 CFN98788
    CAS编号 495-32-9
    分子式 = 分子量 C14H14O4 = 246.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The herbs of Peucedanum decursivum Maxim.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    闹达柯裂亭 CFN98788 495-32-9 10mg QQ客服:1457312923
    闹达柯裂亭 CFN98788 495-32-9 20mg QQ客服:1457312923
    闹达柯裂亭 CFN98788 495-32-9 50mg QQ客服:1457312923
    闹达柯裂亭 CFN98788 495-32-9 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Agricultural Research Organization (ARO) (Israel)
  • University of Queensland (Australia)
  • Helmholtz Zentrum München (Germany)
  • University of Illinois (USA)
  • Universitas islam negeri Jakarta (Indonesia)
  • University of Ioannina (Greece)
  • University of Wisconsin-Madison (USA)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • University of Bordeaux (France)
  • China Medical University (Taiwan)
  • Chiang Mai University (Thailand)
  • Universidad de Buenos Aires (Argentina)
  • Mahidol University (Thailand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Planta Med.2019, 85(4):347-355
  • Antioxidants.2022, 11(4), 67.
  • Molecules2022, 27(3),1140.
  • JLiquid Chromatography & Related Tech.2021, 10826076.
  • Chemistr of plant2016, 2016021195
  • Korean Herb. Med. Inf.2020, 8(2):243-254.
  • Front Neurosci.2019, 13:1091
  • Plant Pathology2022, 13527
  • Academic J of Second Military Medical University2019, 40(1)
  • Chem Res Toxicol. 2022, acs.chemrestox.2c00049.
  • The Malaysian journal of pathology2019, 41(3):243-251
  • Molecules.2019, 24(23):E4303
  • Clin Transl Med.2021, 11(5):e392.
  • Food Chem.2019, 275:746-753
  • Fitoterapia.2018, 124:92-102
  • Fitoterapia.2022, 105141.
  • Molecules.2020, 25(7):1625.
  • J. of Agricultural Science2015, 1916-9760
  • Int J Mol Sci.2017, 19(1)
  • Nat Commun.2019, 10(1):2745
  • JMicrobiol Biotech Food Sci2021, e4289.
  • Aquaculture2019, 510:392-399
  • Biochemical Systematics and Ecology2018, 81
  • ...
  • 生物活性
    Description: Nodakenetin has antioxidant activity, it displays the least irritant and least persistent reactions on mouse ears, and exhibits the least cytotoxic capacity against brine shrimp larvae. Nodakenetin angelate is used as an antiarthritic and nerve tonic.
    Targets: NO
    In vitro:
    Arch Pharm Res. 2012 Jan;35(1):179-92.
    In vitro antioxidant and anti-inflammatory activities of Angelica decursiva.[Pubmed: 22297757 ]
    Mounting evidences continue to support the involvement of oxidative/nitrosative stress and inflammation in the pathogenesis of many diseases. Plant constituents having antioxidant activities together with anti-inflammatory activities may provide better opportunities to develop anti-inflammatory agents.
    METHODS AND RESULTS:
    In view of this, we evaluated the antioxidant and antiinflammatory activities of methanolic extract of whole plants of Angelica decursiva, and its solvent soluble fractions via in vitro activities against lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 cells, as well as in vitro scavenging activities against 1,1-diphenyl-2-picrylhydrazyl, 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid, NO, and peroxynitrite. Among the tested fractions, the ethyl acetate fraction was found as the most active antioxidant fraction together with significant anti-inflammatory effect. From the active ethyl acetate fraction, four coumarin derivatives consisting of nodakenin, Nodakenetin, umbelliferone, and umbelliferone-6-carboxylic acid, along with a phenolic compound, vanillic acid, were isolated. Among them, umbelliferone 6-carboxylic acid and vanillic acid were isolated for the first time from this plant. In all antioxidant assays, vanillic acid showed the highest antioxidant potential followed by umbelliferone 6-carboxylic acid among the isolated compounds. In the anti-inflammatory assay, umbelliferone 6-carboxylic acid exhibited the highest inhibitory activity against lipopolysaccharide-induced NO production in RAW 264.7 cells with an IC(50) value of 72.98 μg/mL.
    CONCLUSIONS:
    Therefore, the present study reveals the potential antioxidant and antiinflammatory activities of whole plants of A. decursiva and its constituents, mainly umbelliferone 6-carboxylic acid, which could be used in the development of therapeutic and preventive agents for oxidative stress-related inflammatory diseases.
    In vivo:
    J Asian Nat Prod Res. 2008 Jan-Feb;10(1-2):49-58.
    Irritant and cytotoxic coumarins from Angelica glauca Edgew roots.[Pubmed: 18058380 ]
    Irritant and cytotoxic potentiality of six coumarins, isolated for the first time from the roots of Angelica glauca identified as 5,6,7-trimethoxycoumarin, 6-methoxy-7,8-methylenedioxycoumarin, bergapten, decursinol angelate, decursin, and Nodakenetin, were investigated.
    METHODS AND RESULTS:
    The irritant potential was explored by open mouse ear assay, evaluating their ID(50) after acute and by IU (Irritant units) after chronic effects, while the cytotoxic capability was explored by their LC(50), using brine shrimp (Artemia salina) larvae (nauplii). All the coumarins exhibited well-defined irritancy on mouse's ears, compared with the positive controlled euphorbium reaction and cytotoxic response against brine shrimp larvae, compared with the positive control colchicine. Decursinol angelate and decursin were the most potent and persistent irritant compounds with least ID(50), whose reactions lasted for 48 h. 6-Methoxy-7,8-methylenedioxycoumarin and bergaten revealed an intermediate irritant reactions, while 5,6,7-trimethoxycoumarin and Nodakenetin displayed the least irritant and least persistent reactions on mouse ears. Both decursin and decursinol angelate also appeared to be the stronger cytotoxic agents than other coumarins.
    CONCLUSIONS:
    5,6,7-trimethoxycoumarin displayed an intermediate cytotoxic behaviour, while other three coumarins, i.e., 6-methoxy-7,8-methylenedioxycoumarin, bergapten, and Nodakenetin, exhibited the least cytotoxic capacity against brine shrimp larvae.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0601 mL 20.3004 mL 40.6009 mL 81.2018 mL 101.5022 mL
    5 mM 0.812 mL 4.0601 mL 8.1202 mL 16.2404 mL 20.3004 mL
    10 mM 0.406 mL 2.03 mL 4.0601 mL 8.1202 mL 10.1502 mL
    50 mM 0.0812 mL 0.406 mL 0.812 mL 1.624 mL 2.03 mL
    100 mM 0.0406 mL 0.203 mL 0.406 mL 0.812 mL 1.015 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5-甲氧基-2',3'-去氢异紫花前胡内酯; 2-(1-Hydroxy-1-methylethyl)-4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one CFN98907 54087-32-0 C15H14O5 = 274.3 5mg QQ客服:215959384
    芸香霉素,芸香亭; Rutaretin CFN97825 13895-92-6 C14H14O5 = 262.26 5mg QQ客服:3257982914
    前胡香豆精 G; Qianhucoumarin G CFN92800 68692-61-5 C14H14O5 = 262.3 5mg QQ客服:2159513211
    闹达柯裂亭; Nodakenetin CFN98788 495-32-9 C14H14O4 = 246.3 20mg QQ客服:2159513211
    异紫花前胡内酯异戊烯酸酯; Isopropylidenylacetyl-marmesin CFN90887 35178-20-2 C19H20O5 = 328.4 20mg QQ客服:215959384
    异紫花前胡素当归酯; Marmesin angelate CFN80120 13209-79-5 C19H20O5 = 328.36 5mg QQ客服:2159513211
    Ammijin; Ammijin CFN92711 495-30-7 C20H24O9 = 408.4 5mg QQ客服:3257982914
    紫花前胡苷; Nodakenin CFN90232 495-31-8 C20H24O9 = 408.40 20mg QQ客服:215959384
    6'-O-(反式阿魏酰基)-紫花前胡苷; 6'-Feruloylnodakenin CFN95202 131623-14-8 C30H32O12 = 584.6 10mg QQ客服:3257982914
    紫花前胡苷I; Decuroside I CFN95004 96638-79-8 C26H34O14 = 570.6 5mg QQ客服:1413575084

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