• 中药标准品生产商,产品定制服务
  • 闹达柯裂亭

    Nodakenetin

    闹达柯裂亭
    产品编号 CFN98788
    CAS编号 495-32-9
    分子式 = 分子量 C14H14O4 = 246.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The herbs of Peucedanum decursivum Maxim.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    闹达柯裂亭 CFN98788 495-32-9 1mg QQ客服:1413575084
    闹达柯裂亭 CFN98788 495-32-9 5mg QQ客服:1413575084
    闹达柯裂亭 CFN98788 495-32-9 10mg QQ客服:1413575084
    闹达柯裂亭 CFN98788 495-32-9 20mg QQ客服:1413575084
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Rio de Janeiro State University (Brazil)
  • University of Minnesota (USA)
  • National Cancer Institute (USA)
  • Seoul National University of Science and Technology (Korea)
  • Chiang Mai University (Thailand)
  • University of Wollongong (Australia)
  • University of Oslo (Norway)
  • Texas A&M University (USA)
  • University of Cincinnati (USA)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Sri Ramachandra University (India)
  • University of Perugia (Italy)
  • Semmelweis Unicersity (Hungary)
  • Cornell University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Ind Crops Prod.2014, 62:173-178
  • Plant Cell,Tissue & Organ Culture2016, 127(1):115-121
  • Food Sci Biotechnol.2016, 25(5):1437-1442
  • Acta Chromatographica2016, 29(3)
  • Vojnosanit Pregl2016, 75(00):391-391
  • Mol Pharm.2017, 14(9):3164-3177
  • Phytochemistry.2017, 141:162-170
  • J Ethnopharmacol.2017, 198:205-213
  • Invest New Drugs.2017, 35(2):166-179
  • FEMS Microbiol Lett.2017, 364(11)
  • J Agric Food Chem.2017, 65(13):2670-2676
  • PLoS One.2018, 13(4):e0195642
  • Nat Prod Sci.2018, 24(2):109-114
  • Curr Eye Res.2018, 43(1):27-34
  • International J of Green Pharmacy2019, 13(3)
  • Molecules.2019, 24(10):E1926
  • Anal Sci.2019, 35(12):1317-1325
  • Int J Mol Med.2019, 43(6):2516-2522
  • J Agric Food Chem.2019, 67(27):7748-7754
  • Phytomedicine.2019, 67:153159
  • Planta Med.2019, 85(9-10):766-773
  • Sci Rep.2019, 9(1):6429
  • Plant Cell Tiss Org2020, 1-16
  • ...
  • 生物活性
    Description: Nodakenetin has antioxidant activity, it displays the least irritant and least persistent reactions on mouse ears, and exhibits the least cytotoxic capacity against brine shrimp larvae. Nodakenetin angelate is used as an antiarthritic and nerve tonic.
    Targets: NO
    In vitro:
    Arch Pharm Res. 2012 Jan;35(1):179-92.
    In vitro antioxidant and anti-inflammatory activities of Angelica decursiva.[Pubmed: 22297757 ]
    Mounting evidences continue to support the involvement of oxidative/nitrosative stress and inflammation in the pathogenesis of many diseases. Plant constituents having antioxidant activities together with anti-inflammatory activities may provide better opportunities to develop anti-inflammatory agents.
    METHODS AND RESULTS:
    In view of this, we evaluated the antioxidant and antiinflammatory activities of methanolic extract of whole plants of Angelica decursiva, and its solvent soluble fractions via in vitro activities against lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 cells, as well as in vitro scavenging activities against 1,1-diphenyl-2-picrylhydrazyl, 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid, NO, and peroxynitrite. Among the tested fractions, the ethyl acetate fraction was found as the most active antioxidant fraction together with significant anti-inflammatory effect. From the active ethyl acetate fraction, four coumarin derivatives consisting of nodakenin, Nodakenetin, umbelliferone, and umbelliferone-6-carboxylic acid, along with a phenolic compound, vanillic acid, were isolated. Among them, umbelliferone 6-carboxylic acid and vanillic acid were isolated for the first time from this plant. In all antioxidant assays, vanillic acid showed the highest antioxidant potential followed by umbelliferone 6-carboxylic acid among the isolated compounds. In the anti-inflammatory assay, umbelliferone 6-carboxylic acid exhibited the highest inhibitory activity against lipopolysaccharide-induced NO production in RAW 264.7 cells with an IC(50) value of 72.98 μg/mL.
    CONCLUSIONS:
    Therefore, the present study reveals the potential antioxidant and antiinflammatory activities of whole plants of A. decursiva and its constituents, mainly umbelliferone 6-carboxylic acid, which could be used in the development of therapeutic and preventive agents for oxidative stress-related inflammatory diseases.
    In vivo:
    J Asian Nat Prod Res. 2008 Jan-Feb;10(1-2):49-58.
    Irritant and cytotoxic coumarins from Angelica glauca Edgew roots.[Pubmed: 18058380 ]
    Irritant and cytotoxic potentiality of six coumarins, isolated for the first time from the roots of Angelica glauca identified as 5,6,7-trimethoxycoumarin, 6-methoxy-7,8-methylenedioxycoumarin, bergapten, decursinol angelate, decursin, and Nodakenetin, were investigated.
    METHODS AND RESULTS:
    The irritant potential was explored by open mouse ear assay, evaluating their ID(50) after acute and by IU (Irritant units) after chronic effects, while the cytotoxic capability was explored by their LC(50), using brine shrimp (Artemia salina) larvae (nauplii). All the coumarins exhibited well-defined irritancy on mouse's ears, compared with the positive controlled euphorbium reaction and cytotoxic response against brine shrimp larvae, compared with the positive control colchicine. Decursinol angelate and decursin were the most potent and persistent irritant compounds with least ID(50), whose reactions lasted for 48 h. 6-Methoxy-7,8-methylenedioxycoumarin and bergaten revealed an intermediate irritant reactions, while 5,6,7-trimethoxycoumarin and Nodakenetin displayed the least irritant and least persistent reactions on mouse ears. Both decursin and decursinol angelate also appeared to be the stronger cytotoxic agents than other coumarins.
    CONCLUSIONS:
    5,6,7-trimethoxycoumarin displayed an intermediate cytotoxic behaviour, while other three coumarins, i.e., 6-methoxy-7,8-methylenedioxycoumarin, bergapten, and Nodakenetin, exhibited the least cytotoxic capacity against brine shrimp larvae.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0601 mL 20.3004 mL 40.6009 mL 81.2018 mL 101.5022 mL
    5 mM 0.812 mL 4.0601 mL 8.1202 mL 16.2404 mL 20.3004 mL
    10 mM 0.406 mL 2.03 mL 4.0601 mL 8.1202 mL 10.1502 mL
    50 mM 0.0812 mL 0.406 mL 0.812 mL 1.624 mL 2.03 mL
    100 mM 0.0406 mL 0.203 mL 0.406 mL 0.812 mL 1.015 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    紫花前胡苷I; Decuroside I CFN95004 96638-79-8 C26H34O14 = 570.6 5mg QQ客服:2159513211
    1'-O-Beta-D-吡喃葡萄糖基-3-羟基闹达柯裂亭; Smyrindioloside CFN97442 87592-77-6 C20H24O10 = 424.4 10mg QQ客服:2932563308
    5-甲氧基-2',3'-去氢异紫花前胡内酯; 2-(1-Hydroxy-1-methylethyl)-4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one CFN98907 54087-32-0 C15H14O5 = 274.3 5mg QQ客服:1413575084
    芸香霉素,芸香亭; Rutaretin CFN97825 13895-92-6 C14H14O5 = 262.26 5mg QQ客服:2159513211
    前胡香豆精 G; Qianhucoumarin G CFN92800 68692-61-5 C14H14O5 = 262.3 5mg QQ客服:3257982914
    闹达柯裂亭; Nodakenetin CFN98788 495-32-9 C14H14O4 = 246.3 10mg QQ客服:215959384
    异紫花前胡内酯异戊烯酸酯; Isopropylidenylacetyl-marmesin CFN90887 35178-20-2 C19H20O5 = 328.4 20mg QQ客服:3257982914
    异紫花前胡素当归酯; Marmesin angelate CFN80120 13209-79-5 C19H20O5 = 328.36 5mg QQ客服:215959384
    Ammijin; Ammijin CFN92711 495-30-7 C20H24O9 = 408.4 5mg QQ客服:3257982914
    紫花前胡苷; Nodakenin CFN90232 495-31-8 C20H24O9 = 408.40 20mg QQ客服:1148253675

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产