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  • 桑辛素

    Morusin

    桑辛素
    产品编号 CFN97083
    CAS编号 62596-29-6
    分子式 = 分子量 C25H24O6 = 420.5
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The root barks of Morus alba L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    桑辛素 CFN97083 62596-29-6 10mg QQ客服:1413575084
    桑辛素 CFN97083 62596-29-6 20mg QQ客服:1413575084
    桑辛素 CFN97083 62596-29-6 50mg QQ客服:1413575084
    桑辛素 CFN97083 62596-29-6 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Ioannina (Greece)
  • Weizmann Institute of Science (Israel)
  • National Cancer Institute (USA)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • University Medical Center Mainz (Germany)
  • University of Illinois at Chicago (USA)
  • National Cancer Center Research Institute (Japan)
  • University of Minnesota (USA)
  • Subang Jaya Medical Centre (Malaysia)
  • Medical University of South Carolina (USA)
  • University of Hawaii Cancer Center (USA)
  • University of Liège (Belgium)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Ain Shams University (Egypt)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Acta Physiologiae Plantarum2015, 37:1736
  • FEBS Lett.2015, 589(1):182-7
  • Proc Natl Acad Sci USA.2016, 113(30):E4407-1
  • Acta Chromatographica2016, 29(3)
  • Am J Chin Med.2016, 44(8):1719-1735
  • Phytochemistry.2017, 141:162-170
  • J Nat Med.2017, 71(2):380-388
  • Anal Chim Acta.2018, 1039:162-171
  • Phytochemistry2018, 15:83-92
  • J of the Society of Cosmetic Scientists of Korea2018, 44(4):407-417
  • Korean Journal of Pharmacognosy2018, 49(4):349-361
  • Sci Rep.2018, 8(1):12970
  • J Nat Prod.2018, 81(4):966-975
  • Saf Health Work.2019, 10(2):196-204
  • Front Pharmacol.2019, 10:1226
  • Biomed Pharmacother.2019, 116:108987
  • J of Essential Oil Research2019, 1677272
  • Molecules.2019, 24(4):E709
  • Anal Biochem.2019, 569:10-15
  • Appl Biol Chem2019, 62:46
  • Environ Toxicol Pharmacol.2019, 66:109-115
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • Int Immunopharmacol.2019, 71:22-31
  • ...
  • 生物活性
    Description: Morusin exhibits antinociceptive, analgesic, anticonvulsant, antibacterial, and antitumor activities. Morusin can inhibit NF-κB and STAT3 activity, activate caspases activity, and restorate GABA level.
    Targets: MMP(e.g.TIMP) | STAT | NF-kB | Bcl-2/Bax | Caspase | Antifection | GABA Receptor | PDK | PI3K | Akt | IkB | IKK
    In vitro:
    Toxicol Lett. 2015 Jan 22;232(2):490-8.
    Antitumor progression potential of morusin suppressing STAT3 and NFκB in human hepatoma SK-Hep1 cells.[Pubmed: 25476160]
    Morusin is a prenylated flavonoid that has been isolated from the root bark of the mulberry tree (Morus species, Moraceae), a Chinese traditional medicine. It has been synthesized by our laboratory from commercially available phloroglucinol, and has demonstrated to possess antitumor effects of cell lines including A549, MCF-7, and MDA-MB-231.
    METHODS AND RESULTS:
    In this study, at non-cytotoxic concentrations, morusin altered invasive morphology and suppressed cell-matrix adhesion, cell motility and cell invasion in SK-Hep1 cells. Morusin also increased the expression of E-cadherin, an epithelial cell junction protein, decreased the expression of vimentin, a mesecnchymal marker, and α2-, α6-, β1- integrin, which regulated cancer attachment and migration. In addition, morusin reduced the activity of matrix metalloproteinase-2 and 9 (MMP-2 and MMP-9), which were involved in extracellular matrix (ECM) degradation and promoting cancer cell invasion. Furthermore, morusin suppressed the signal transducer and activator of transcription 3 (STAT3) and nuclear factor-κB (NFκB) signaling pathways, which modulate the protein expression involved in the invasion process. Finally, morusin decreased the lung colonization of the SK-Hep1 cells in the nude mice.
    CONCLUSIONS:
    These results indicate morusin possesses antitumor progression potential through suppressing STAT3 and NFκB.
    Mol Carcinog. 2014 Dec 31.
    Morusin inhibits glioblastoma stem cell growth in vitro and in vivo through stemness attenuation, adipocyte transdifferentiation, and apoptosis induction.[Pubmed: 25557841]
    Glioblastoma multiforme (GBM) cancer stem cells (GSCs) are responsible for the progression and recurrence of GBM after conventional therapy. Morusin possesses anti-cancer activity in vitro. The purpose of this study is to confirm the growth inhibition effect of morusin on human GSCs growth in vitro and in vivo and to explore the possible mechanism of its activity.
    METHODS AND RESULTS:
    Human GSCs were enriched under nonadhesive culture system, and characterized through neurosphere formation, toluidine blue staining, immunofluorescence staining, Western blotting analysis of stemness markers of CD133, nestin, Sox2 and Oct4, and tumorigenecity in vivo; the growth inhibition effect of morusin on human GSCs in vitro and in vivo were tested by cell cytotoxicity, neurosphere formation inhibition, adipogenic differentiation, apoptosis induction, and tumor growth inhibition in vivo assays. The potential molecular mechanisms underlying the growth inhibition effect of morusin on GSCs in vitro and in vivo were investigated with Western blotting evaluation of stemness, adipogenic, and apoptotic proteins in morusin treated GSCs and tumor tissues. GSCs enriched under nonadhesive culture system possess stemness characterstics; Morusin inhibited GSCs growth in vitro and in vivo, it reduced stemness of GSCs, induced them adipocyte-like transdifferention and apoptosis.
    CONCLUSIONS:
    Morusin has the potential to inhibit human GSCs growth in vitro and in vivo through stemness attenuation, adipocyte transdifferentiation, and apoptosis induction.
    Science of Sericulture, 2013, 39(6):1150-4.
    An Investigation on Antibacterial Activity and Stability of Morusin.[Reference: WebLink]

    METHODS AND RESULTS:
    In this study,inhibitory effects of Morusin from mulberry( Morus L.) against 5 common food-borne pathogenic bacteria,namely Staphyloccocus aureus,Bacillus subtilis,Escherichia coli,Salmonella spp. and Proteus vulgaris,were tested by agar diffusion method and microscale double dilution method. Meanwhile,the effects of thermal treatment,ultraviolet illumination,medium pH value,oxidant and reducer on the antibacterial activity of Morusin were also investigated. The results indicated that inhibitory effects of Morusin against the 5 tested bacterial strains were different. The two Gram-positive bacteria( G+),Bacillus subtilis and Staphylococcus aureus,were remarkably inhibited. Morusin had the highest antibacterial activity against Bacillus subtilis,with the minimum inhibitory concentration( MIC) below 1. 56μg /mL. Its inhibition to the three Gram-negative bacteria( G-),Salmonella spp.,P. vulgaris and E. coli,was relatively weak. Ultraviolet illumination and thermal treatment below 100 ℃ had no obvious influence on the antibacterial activity of Morusin. After thermal treatment of above100 ℃,the antibacterial activity of Morusin decreased obviously. Within pH 6 ~ 9 range,the antibacterial activity of Morusin decreased with increase of medium pH value.When the concentration of reducer Na2SO3was increased,the antibacterial activity of Morusin to Staphylococcus aureus declined gradually. The concentration of oxidant H2O2 had little influence on the antibacterial activity of Morusin.
    CONCLUSIONS:
    These results suggest that Morusin is one of the important substances of mulberry with antibacterial activity. High temperature( above 100 ℃),strong alkaline and high concentration reducer had influence on the antibacterial activity of Morusin.
    In vivo:
    Z Naturforsch C. 2000 Mar-Apr;55(3-4):256-60.
    Antinociceptive properties of morusin, a prenylflavonoid isolated from Morus nigra root bark.[Pubmed: 10817216]
    The antinociceptive effects of morusin (1), the main prenylflavonoid present in the Morus nigra root barks have been investigated in classical models of pain in mice.
    METHODS AND RESULTS:
    The results showed that 1 exhibits a promising antinociceptive or analgesic profile by the intraperitoneal route, being more potent than some standard drugs used as reference.
    CONCLUSIONS:
    The mechanism by which the morusin exerts antinociceptive activity still remains undetermined, but our results strongly suggest that it involves the participation of the opioid system.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3781 mL 11.8906 mL 23.7812 mL 47.5624 mL 59.453 mL
    5 mM 0.4756 mL 2.3781 mL 4.7562 mL 9.5125 mL 11.8906 mL
    10 mM 0.2378 mL 1.1891 mL 2.3781 mL 4.7562 mL 5.9453 mL
    50 mM 0.0476 mL 0.2378 mL 0.4756 mL 0.9512 mL 1.1891 mL
    100 mM 0.0238 mL 0.1189 mL 0.2378 mL 0.4756 mL 0.5945 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    桑皮酮A; Kuwanon A CFN90834 62949-77-3 C25H24O6 = 420.5 5mg QQ客服:2159513211
    桑根酮K; Sanggenone K CFN92416 86450-77-3 C30H32O6 = 488.6 5mg QQ客服:2159513211
    桑皮酮H; Kuwanon H CFN90835 76472-87-2 C45H44O11 = 760.8 10mg QQ客服:1148253675
    3-香叶基-5,7,2',4'-四羟基黄酮; 5,7,2',4'-Tetrahydroxy-3-geranylflavone CFN92322 376361-87-4 C25H26O6 = 422.5 5mg QQ客服:2932563308
    桑黄酮; 桑皮黄素; Mulberrin CFN97085 62949-79-5 C25H26O6 = 422.5 10mg QQ客服:1413575084
    桑辛素; Morusin CFN97083 62596-29-6 C25H24O6 = 420.5 20mg QQ客服:215959384
    桑根皮醇; Morusinol CFN97086 62949-93-3 C25H26O7 = 438.5 5mg QQ客服:2159513211
    8-Isomulberrin hydrate; 8-Isomulberrin hydrate CFN97581 N/A C25H28O7 = 440.5 5mg QQ客服:2932563308
    桂木黄素; 2',4',5-三羟基-7-甲氧基-6-(3-甲基-1-丁烯基)-3-(3-甲基-2-丁烯基)黄酮; Artocarpin CFN97239 7608-44-8 C26H28O6 = 436.5 5mg QQ客服:2932563308
    3'-牻牛儿基-3-异戊烯基-5,7,2',4'-四羟基黄酮; 3'-Geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone CFN97892 1334309-44-2 C30H34O6 = 490.6 10mg QQ客服:3257982914

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