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  • 大果桉醛C

    Macrocarpal C

    大果桉醛C
    产品编号 CFN99469
    CAS编号 142628-53-3
    分子式 = 分子量 C28H38O5 = 454.6
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Sesquiterpenoids
    植物来源 The branches of Eucalyptus globulus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    大果桉醛C CFN99469 142628-53-3 1mg QQ客服:2159513211
    大果桉醛C CFN99469 142628-53-3 5mg QQ客服:2159513211
    大果桉醛C CFN99469 142628-53-3 10mg QQ客服:2159513211
    大果桉醛C CFN99469 142628-53-3 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Chem Pharm Bull (Tokyo).2017, 65(9):826-832
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  • LWT2020, 130:109535
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  • Appl. Sci.2023, 13(17), 9653.
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  • Horticulturae2022, 8(10), 975.
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
  • J Cell Mol Med.2021, 25(5):2645-2654.
  • Oncol Rep.2016, 35(3):1356-64
  • J Anal Toxicol.2021, bkab015.
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  • Plant Direct.2021, 5(4):e00318.
  • Journal of Functional Foods2017, 30:30-38
  • ...
  • 生物活性
    Description: Macrocarpal C, isolated from the fresh leaves of Eucalyptus globulus Labill. (Lan An) and identified as its major antifungal component by bioassay-guided purification, the antifungal action of macrocarpal C was associated with increases of membrane permeability, intracellular ROS and DNA fragmentation.
    Targets: ROS | Antifection
    In vitro:
    Am J Chin Med. 2010;38(5):1005-14.
    Two antifungal components isolated from Fructus Psoraleae and Folium Eucalypti Globuli by bioassay-guided purification.[Pubmed: 20821830]
    Fructus Psoraleae and Folium Eucalypti Globuli have long been used as Chinese medicines to treat various ailments such as asthma, eczema and dermatomycosis. In previous studies, their antifungal activities were demonstrated. The aim of the present study was to isolate active antidermatophytic compounds from their ethanolic extracts by means of bioassay-guided purification.
    METHODS AND RESULTS:
    Guided by the inhibitory activities on Trichophyton mentagrophytes, Trichophyton rubrum and Paecilomyces variotii, bakuchiol was isolated from the n-hexane fraction of Fructus Psoraleae whilst Macrocarpal C was isolated from the n-hexane fraction of Folium Eucalypti Globuli. Both pure compounds could effectively inhibit the growth of dermatophytes in vitro.
    CONCLUSIONS:
    This is the first paper to report the isolation and identification of active antidermatophytic compounds from Fructus Psoraleae and Folium Eucalypti Globuli by the bioassay-guided purification.
    Chin Med. 2015 Nov 21;10:34.
    Antifungal mode of action of macrocarpal C extracted from Eucalyptus globulus Labill (Lan An) towards the dermatophyte Trichophyton mentagrophytes.[Pubmed: 26594235 ]
    The fresh leaves of Eucalyptus globulus Labill. (Lan An) have been used in Chinese medicine for many years to treat dermatomycosis. Macrocarpal C was isolated from this herb and identified as its major antifungal component by bioassay-guided purification. This study aims to investigate the antifungal activity of Macrocarpal C against Trichophyton mentagrophytes, which can cause tinea pedis.
    METHODS AND RESULTS:
    The suppression in the growth of T. mentagrophytes following its treatment with Macrocarpal C was associated with an increase in the permeability of the fungal membrane (P = 0.0043 when compared to control); an increase in the production of intracellular ROS (P = 0.0063); and the induction of apoptosis as a consequence of DNA fragmentation (P = 0.0007). CONCLUSION:
    CONCLUSIONS:
    This study demonstrated that the antifungal action of Macrocarpal C was associated with increases of membrane permeability, intracellular ROS and DNA fragmentation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1997 mL 10.9987 mL 21.9974 mL 43.9947 mL 54.9934 mL
    5 mM 0.4399 mL 2.1997 mL 4.3995 mL 8.7989 mL 10.9987 mL
    10 mM 0.22 mL 1.0999 mL 2.1997 mL 4.3995 mL 5.4993 mL
    50 mM 0.044 mL 0.22 mL 0.4399 mL 0.8799 mL 1.0999 mL
    100 mM 0.022 mL 0.11 mL 0.22 mL 0.4399 mL 0.5499 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    大果桉醛C; Macrocarpal C CFN99469 142628-53-3 C28H38O5 = 454.6 5mg QQ客服:3257982914
    大果桉醛A; Macrocarpal A CFN99413 132951-90-7 C28H40O6 = 472.6 5mg QQ客服:3257982914
    大果桉醛B; Macrocarpal B CFN99472 142698-60-0 C28H40O6 = 472.6 5mg QQ客服:215959384
    大果桉醛D; Macrocarpal D CFN99471 142647-71-0 C28H40O6 = 472.6 5mg QQ客服:2056216494
    桉树脑; Eucalyptone CFN99813 172617-99-1 C28H38O7 = 486.6 5mg QQ客服:1457312923
    大果桉醛N; Macrocarpal N CFN99008 221899-21-4 C28H38O7 = 486.6 5mg QQ客服:3257982914

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