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    羽扇豆醇 3-乙酸酯

    Lupeol acetate

    羽扇豆醇 3-乙酸酯
    产品编号 CFN96583
    CAS编号 1617-68-1
    分子式 = 分子量 C32H52O2 = 468.77
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The stem barks of Himatanthus drasticus (Mart.) Plumel.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    羽扇豆醇 3-乙酸酯 CFN96583 1617-68-1 1mg QQ客服:2159513211
    羽扇豆醇 3-乙酸酯 CFN96583 1617-68-1 5mg QQ客服:2159513211
    羽扇豆醇 3-乙酸酯 CFN96583 1617-68-1 10mg QQ客服:2159513211
    羽扇豆醇 3-乙酸酯 CFN96583 1617-68-1 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sri Ramachandra University (India)
  • University of Perugia (Italy)
  • University of Medicine and Pharmacy (Romania)
  • Texas A&M University (USA)
  • Griffith University (Australia)
  • University of Canterbury (New Zealand)
  • Celltrion Chemical Research Institute (Korea)
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  • Heinrich-Heine-University Düsseldorf (Germany)
  • Harvard University (USA)
  • University of Illinois (USA)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • China Pharmacy2015, 26(27)
  • Mediators Inflamm. 2016, 2016:6189590
  • The Korea Journal of Herbology2016, 29-35
  • Korean Herb. Med. Inf. 2016, 4(1):35-42
  • Free Radic Biol Med.2017, 112:191-199
  • Nat Prod Commun.2017, 12(5):771-778
  • Plant J.2017, 90(3):535-546
  • Nutrients.2018, 10(7)
  • Molecules.2018, 23(3):E615
  • J Mol Med (Berl).2018, 96(7):661-672
  • J Nat Sc Biol Med2019, 10(2):149-156
  • Int J Mol Sci.2019, 20(16):E4015
  • Int J Mol Sci.2019, 20(23):E6071
  • Int J Mol Sci.2019, 20(3):E651
  • J of the Korean Society of Cosmetics and Cosmetology2019, 225-231
  • Food Chem.2019, 274:345-350
  • Pharmaceutical Chemistry Journal2019, 52(12):986-991
  • Anal Biochem.2019, 569:10-15
  • Industrial Crops and Products2020, 146:112186
  • Appl. Sci.2020, 10(5),1713.
  • Int J Mol Sci.2020, 21(8):2790.
  • J Ethnopharmacol.2021, 267:113615.
  • Horticulturae2021, 7(1),5.
  • ...
  • 生物活性
    Description: Lupeol acetate possesses antinociceptive, antifertility, and anti-inflammatory properties, the effect probably involves the opioid system, as indicated by the complete blockade of the opioid antagonist naloxone. Lupeol acetate can significantly improve the symptoms of RA by down-regulating expressions of inflammatory cytokines and osteoclastogenesis.
    Targets: TNF-α | NO | NOS | COX | PGE
    In vivo:
    Pharmacology. 2005 Oct;75(2):57-62.
    Induction of antifertility with lupeol acetate in male albino rats.[Pubmed: 16015025 ]
    The present study was undertaken to evaluate the antifertility activity of the active principle, i.e. lupeol acetate, isolated from benzene extract of Alstonia scholaris in male albino rats.
    METHODS AND RESULTS:
    The treatment with lupeol acetate at the dose level of 10 mg/rat/day did not cause any significant change in the body weights, but significant reduction in the weight of reproductive organs, i.e. testes, epididymides, seminal vesicle and ventral prostate, was observed. Testicular sperm count, epididymal sperm count and motility were found significantly declined when compared with controls, which resulted in reduction of male fertility by 100%. Arrest of spermatogenesis was noted at various stages with production of primary spermatocytes (preleptotene and pachytene), secondary spermatocytes and step-19 spermatids were decreased by 52.36, 54.91, 55.67 and 69.65%, respectively. The seminiferous tubules appeared reduced in size by 24.62%. Cross-sectional surface area of Sertoli cells as well as their counts were found to be significantly depleted. Leydig cell nuclear area and number of mature Leydig cells were decreased by 27.65 and 35.47%. Biochemical parameters of tissues i.e. protein, sialic acid, glycogen and cholesterol content of testes and seminal vesicular fructose also showed significant reduction.
    Evid Based Complement Alternat Med. 2012;2012:371273.
    Balanophora spicata and Lupeol Acetate Possess Antinociceptive and Anti-Inflammatory Activities In Vivo and In Vitro.[Pubmed: 23243439 ]
    Aims of the present study were to investigate effects of Balanophora spicata (BS) on antinociception and anti-inflammation both in vivo and in vitro.
    METHODS AND RESULTS:
    Crude extract of BS inhibited vascular permeability induced by histamine, serotonin, bradykinin, and PGE(2), but not by PAF. Furthermore, BS crude extract, different layers (n-hexane, ethyl acetate, n-butanol, and water layer), and Lupeol acetate had significant antinociceptive and anti-inflammatory effects on acetic acid-induced abdominal writhing response, formalin-induced licking behavior, carrageenan-, and serotonin-induced paw edema. The n-hexane layer had the most effective potency among all layers (IC50: 67.33 mg/kg on writhing response; IC50s: 34.2 mg/kg and 21.29 mg/kg on the early phase and late phase of formalin test, resp.). Additionally, Lupeol acetate which was isolated from the n-hexane layer of BS effectively inhibited the acetic acid-induced writhing response (IC50: 28.32 mg/kg), formalin-induced licking behavior (IC50: 20.95 mg/kg), NO production (IC50: 4.102 μM), iNOS expression (IC50: 5.35 μM), and COX2 expression (IC50: 5.13 μM) in LPS-stimulated RAW 264.7 cells.
    CONCLUSIONS:
    In conclusion, BS has antinociceptive and anti-inflammatory effects which may be partially due to the inhibition of changes in vascular permeability induced by histamine, serotonin, bradykinin, and PGE(2) and the attenuation of iNOS and COX-2 expression.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1332 mL 10.6662 mL 21.3324 mL 42.6648 mL 53.3311 mL
    5 mM 0.4266 mL 2.1332 mL 4.2665 mL 8.533 mL 10.6662 mL
    10 mM 0.2133 mL 1.0666 mL 2.1332 mL 4.2665 mL 5.3331 mL
    50 mM 0.0427 mL 0.2133 mL 0.4266 mL 0.8533 mL 1.0666 mL
    100 mM 0.0213 mL 0.1067 mL 0.2133 mL 0.4266 mL 0.5333 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Adiantulupanone; Adiantulupanone CFN89066 51511-05-8 C29H48O = 412.70 5mg QQ客服:1457312923
    3beta-羟基-30-去甲羽扇烷; 29-Nor-20-oxolupeol CFN96388 19891-85-1 C29H48O2 = 428.7 5mg QQ客服:1413575084
    (3beta)-3-羟基羽扇-20(30)-烯-29-醛; 30-Oxolupeol CFN96383 64181-07-3 C30H48O2 = 440.7 5mg QQ客服:2159513211
    算盘子酮醇; Glochidonol CFN98248 23963-54-4 C30H48O2 = 440.7 5mg QQ客服:2932563308
    算盘子酮; Glochidone CFN97127 6610-55-5 C30H46O = 422.7 5mg QQ客服:2056216494
    羽扇烯酮; Lupenone CFN99681 1617-70-5 C30H48O = 424.7 10mg QQ客服:2056216494
    羽扇-20(29)-烯-3bate,23-二醇; Lup-20(29)-ene-3bate,23-diol CFN96184 163060-07-9 C30H50O2 = 442.7 5mg QQ客服:2056216494
    Lupeolic acid; Lupeolic acid CFN96255 87355-32-6 C30H48O3 = 456.7 5mg QQ客服:2056216494
    羽扇豆醇 3-乙酸酯 ; Lupeol acetate CFN96583 1617-68-1 C32H52O2 = 468.77 10mg QQ客服:2056216494
    咖啡酸羽扇豆醇酯; Lupeol caffeate CFN99057 103917-26-6 C39H56O4 = 588.9 5mg QQ客服:3257982914

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