羽扇豆醇

Lupeol

	产品编号	CFN98913
	CAS编号	545-47-1
	分子式 = 分子量	C₃₀H₅₀O = 426.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The flower of Chrysanthemum morifolium
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
羽扇豆醇	CFN98913	545-47-1	10mg	QQ客服：1413575084
羽扇豆醇	CFN98913	545-47-1	20mg	QQ客服：1413575084
羽扇豆醇	CFN98913	545-47-1	50mg	QQ客服：1413575084
羽扇豆醇	CFN98913	545-47-1	100mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

1. Lupeol has a potential to act as an anti-inflammatory, anti-microbial, anti-protozoal, anti-proliferative, anti-invasive, anti-angiogenic, antimalarial and cholesterol lowering agent.
2. Lupeol prevents acetaminophen-induced in vivo hepatotoxicity by altering the Bax/Bcl-2 and oxidative stress-mediated mitochondrial signaling cascade.
3. Lupeol and its ester derivative have beneficial effects on hypercholesterolemia-induced oxidative and inflammatory stresses.
4. Lupeol significantly enhances the radiosensitivity of SMMC-7721 cells in vitro and in vivo.
5. Lupeol shows antidiabetic and antioxidant potential in experimental hyperglycaemia.
6. Lupeol has potential anticancer effect against hepatocellular and pancreatic cancer, by inhibiting cell proliferation, inducing apoptosis and blocking Akt/PI3K and Wnt signaling pathway.
7. Lupeol has antiangiogenic effects, it (at 50 and 30 microg/mL) shows a marked inhibitory activity on human umbilical venous endothelial cells (HUVEC) tube formation while it does not affect the growth of tumor cell lines such as SK-MEL-2, A549, and B16-F10 melanoma.

Targets:

In vitro:

Clin Cancer Res . 2011 Aug 15;17(16):5379-91.

Lupeol, a novel androgen receptor inhibitor: implications in prostate cancer therapy[Pubmed: 21712449]

Abstract Purpose: Conventional therapies to treat prostate cancer (CaP) of androgen-dependent phenotype (ADPC) and castration-resistant phenotype (CRPC) are deficient in outcome which has necessitated a need to identify those agents that could target AR for both disease types. We provide mechanism-based evidence that lupeol (Lup-20(29)-en-3b-ol) is a potent inhibitor of androgen receptor (AR) in vitro and in vivo. Experimental design: Normal prostate epithelial cell (RWPE-1), LAPC4 (wild functional AR/ADPC), LNCaP (mutant functional/AR/ADPC), and C4-2b (mutant functional/AR/CRPC) cells were used to test the anti-AR activity of lupeol. Cells grown under androgen-rich environment and treated with lupeol were tested for proliferation, AR transcriptional activity, AR competitive ligand binding, AR-DNA binding, and AR-ARE/target gene binding. Furthermore, in silico molecular modeling for lupeol-AR binding was done. Athymic mice bearing C4-2b and LNCaP cell-originated tumors were treated intraperitoneally with lupeol (40 mg/kg; 3 times/wk) and tumor growth and surrogate biomarkers were evaluated. To assess bioavailability, lupeol serum levels were measured. Results: Lupeol significantly inhibited R1881 (androgen analogue) induced (i) transcriptional activity of AR and (ii) expression of PSA. Lupeol (i) competed antagonistically with androgen for AR, (ii) blocked the binding of AR to AR-responsive genes including PSA, TIPARP, SGK, and IL-6, and (iii) inhibited the recruitment of RNA Pol II to target genes. Lupeol sensitized CRPC cells to antihormone therapy. High-performance liquid chromatography analysis showed that lupeol is bioavailable to mice. Lupeol inhibited the tumorigenicity of both ADPC and CRPC cells in animals. Serum and tumor tissues exhibited reduced PSA levels. Conclusion: Lupeol, an effective AR inhibitor, could be developed as a potential agent to treat human CaP.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
羽扇豆醇 3-乙酸酯 ; Lupeol acetate	CFN96583	1617-68-1	C₃₂H₅₂O₂ = 468.77	10mg	QQ客服：3257982914
咖啡酸羽扇豆醇酯; Lupeol caffeate	CFN99057	103917-26-6	C₃₉H₅₆O₄ = 588.9	5mg	QQ客服：1457312923
2alpha-羟基羽扇豆醇; Lup-20(29)-ene-2alpha,3beta-diol	CFN97717	61448-03-1	C₃₀H₅₀O₂ = 442.73	5mg	QQ客服：215959384
算盘子二醇; Glochidiol	CFN97128	6610-56-6	C₃₀H₅₀O₂ = 442.7	5mg	QQ客服：215959384
3-表算盘子二醇; 3-Epiglochidiol	CFN98360	29028-10-2	C₃₀H₅₀O₂ = 442.7	5mg	QQ客服：3257982914
3-表算盘子二醇二乙酸酯; 3-Epiglochidiol diacetate	CFN97122	6587-37-7	C₃₄H₅₄O₄ = 526.8	5mg	QQ客服：1457312923
11β-羟基羽扇豆醇; 11beta-Hydroxylupeol	CFN89288	49776-92-3	C₃₀H₅₀O₂ = 442.72	5mg	QQ客服：2056216494
钝鸡蛋花素; Obtusalin	CFN91560	125164-64-9	C₃₀H₅₀O₂ = 442.7	5mg	QQ客服：3257982914
Adiantulupanone; Adiantulupanone	CFN89066	51511-05-8	C₂₉H₄₈O = 412.70	5mg	QQ客服：1413575084
3beta-羟基-30-去甲羽扇烷; 29-Nor-20-oxolupeol	CFN96388	19891-85-1	C₂₉H₄₈O₂ = 428.7	5mg	QQ客服：1413575084

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3436 mL	11.7178 mL	23.4357 mL	46.8713 mL	58.5892 mL
5 mM	0.4687 mL	2.3436 mL	4.6871 mL	9.3743 mL	11.7178 mL
10 mM	0.2344 mL	1.1718 mL	2.3436 mL	4.6871 mL	5.8589 mL
50 mM	0.0469 mL	0.2344 mL	0.4687 mL	0.9374 mL	1.1718 mL
100 mM	0.0234 mL	0.1172 mL	0.2344 mL	0.4687 mL	0.5859 mL

羽扇豆醇

Lupeol

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