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  • 羽扇烯酮

    Lupenone

    羽扇烯酮
    产品编号 CFN99681
    CAS编号 1617-70-5
    分子式 = 分子量 C30H48O = 424.7
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Triterpenoids
    植物来源 The roots of Pueraria thomsonii Benth.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    羽扇烯酮 CFN99681 1617-70-5 1mg QQ客服:215959384
    羽扇烯酮 CFN99681 1617-70-5 5mg QQ客服:215959384
    羽扇烯酮 CFN99681 1617-70-5 10mg QQ客服:215959384
    羽扇烯酮 CFN99681 1617-70-5 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Limpopo (South Africa)
  • Kyung Hee University (Korea)
  • University of Vigo (Spain)
  • Ateneo de Manila University (Philippines)
  • St. Jude Children Research Hospital (USA)
  • University of Hull (United Kingdom)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • University of Wuerzburg (Germany)
  • Semmelweis Unicersity (Hungary)
  • Pennsylvania State University (USA)
  • Sanford Burnham Medical Research Institute (USA)
  • Anna University (India)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Max Rubner-Institut (MRI) (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacogn Mag.2015, 11:S585-91
  • Int J Mol Sci.2015, 16(8):18396-411
  • Phytomedicine.2015, 22(4):498-503
  • Mol Cells.2015, 38(9):765-72
  • Korean Journal of Pharmacognosy.2015, 46(4):352-364
  • Acta Chromatographica2016, 29(3)
  • Acta Physiologiae Plantarum2016, 38:7
  • PLoS One.2017, 12(8):e0181191
  • Front Immunol.2017, 8:1542
  • Nutrients.2018, 10(10)
  • PLoS One.2018, 13(11):e0208055
  • Br J Pharmacol.2018, 175(6):902-923
  • International Food Research Journal2018, 25(6):2560-2571
  • Korean J Environ Agric.2018, 37(4):260-267
  • J Sep Sci.2018, 41(11):2488-2497
  • Drug Invention Today2019, 12(6):1303-1306
  • Nutr Metab (Lond).2019, 16:31
  • Exp Biol Med (Maywood).2019, 244(18):1665-1679
  • Food Chem.2019, 276:768-775
  • Anal Biochem.2019, 569:10-15
  • J of Ana. Chem.2019, 74(11):1113-1121
  • Food Sci Nutr.2019, 8(1):246-256
  • J Cell Physiol.2020, 10.1002
  • ...
  • 生物活性
    Description: Lupenone and lupeol inhibit protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 13.7 ± 2.1 and 5.6 ± 0.9 uM, respectively, they are non−competitive inhibitors of PTP1B, and PTP1B appears to be an attractive target for the development of new drugs for type 2 diabetes and obesity. Lupenone stimulates melanogenesis by increasing the tyrosinase enzyme expression via mitogen-activated protein kinase phosphorylated extracellular signal-regulated kinases 1 and 2 phosphorylation inhibition. A 1 : 4 mixture of Lupenone and caryophyllene oxide shows trypanocidal activity.
    Targets: PPAR | ERK | MAPK | Antifection | PTP1B
    In vitro:
    Phytother Res. 2013 May;27(5):761-6.
    Lupenone isolated from Adenophora triphylla var. japonica extract inhibits adipogenic differentiation through the downregulation of PPARγ in 3T3-L1 cells.[Pubmed: 22848028]
    Adenophora triphylla var. japonica (Campanulaceae) is known to have anti-inflammatory and anti-tussive effects. Dysfunction of adipocytes and adipose tissue in obesity is related to various inflammatory cytokines or adipokines.
    METHODS AND RESULTS:
    In this study, we investigated whether lupenone isolated from A. triphylla var. japonica extract inhibits adipocyte differentiation and expression of adipogenic marker genes in 3T3-L1 preadipocytes. We demonstrated that lupenone resulted in a significant reduction in lipid accumulation and expression of adipogenic marker genes in a dose-dependent manner. In addition, lupenone decreased the transcriptional activity of peroxisome proliferator-activated receptor γ (PPARγ) induced by troglitazone, and we also demonstrated that lupenone suppressed the PPARγ and CCAAT-enhancer-binding protein α (C/EBPα) protein levels.
    CONCLUSIONS:
    These findings demonstrated that lupenone isolated from A. triphylla var. japonica extract effectively inhibited adipocyte differentiation through downregulation of related transcription factor, particularly the PPARγ gene.
    Evid Based Complement Alternat Med. 2013;2013:435398.
    Synergistic Effect of Lupenone and Caryophyllene Oxide against Trypanosoma cruzi.[Pubmed: 23762135]
    The in vitro trypanocidal activity of a 1 : 4 mixture of lupenone and caryophyllene oxide confirmed a synergistic effect of the terpenoids against epimastigotes forms of T. cruzi (IC50 = 10.4  μ g/mL, FIC = 0.46). In addition, testing of the terpenoid mixture for its capacity to reduce the number of amastigote nests in cardiac tissue and skeletal muscle of infected mice showed a reduction of more than 80% at a dose level of 20.8 mg·kg(-1)·day(-1).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3546 mL 11.773 mL 23.546 mL 47.0921 mL 58.8651 mL
    5 mM 0.4709 mL 2.3546 mL 4.7092 mL 9.4184 mL 11.773 mL
    10 mM 0.2355 mL 1.1773 mL 2.3546 mL 4.7092 mL 5.8865 mL
    50 mM 0.0471 mL 0.2355 mL 0.4709 mL 0.9418 mL 1.1773 mL
    100 mM 0.0235 mL 0.1177 mL 0.2355 mL 0.4709 mL 0.5887 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    羽扇豆醇 3-乙酸酯 ; Lupeol acetate CFN96583 1617-68-1 C32H52O2 = 468.77 10mg QQ客服:1148253675
    咖啡酸羽扇豆醇酯; Lupeol caffeate CFN99057 103917-26-6 C39H56O4 = 588.9 5mg QQ客服:1148253675
    2alpha-羟基羽扇豆醇; Lup-20(29)-ene-2alpha,3beta-diol CFN97717 61448-03-1 C30H50O2 = 442.73 5mg QQ客服:1148253675
    算盘子二醇; Glochidiol CFN97128 6610-56-6 C30H50O2 = 442.7 5mg QQ客服:3257982914
    3-表算盘子二醇; 3-Epiglochidiol CFN98360 29028-10-2 C30H50O2 = 442.7 5mg QQ客服:3257982914
    3-表算盘子二醇二乙酸酯; 3-Epiglochidiol diacetate CFN97122 6587-37-7 C34H54O4 = 526.8 5mg QQ客服:215959384
    11β-羟基羽扇豆醇; 11beta-Hydroxylupeol CFN89288 49776-92-3 C30H50O2 = 442.72 5mg QQ客服:2932563308
    Adiantulupanone; Adiantulupanone CFN89066 51511-05-8 C29H48O = 412.70 5mg QQ客服:1413575084
    3beta-羟基-30-去甲羽扇烷; 29-Nor-20-oxolupeol CFN96388 19891-85-1 C29H48O2 = 428.7 5mg QQ客服:2932563308
    (3beta)-3-羟基羽扇-20(30)-烯-29-醛; 30-Oxolupeol CFN96383 64181-07-3 C30H48O2 = 440.7 5mg QQ客服:215959384

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