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  • 党参炔苷

    Lobetyolin

    党参炔苷
    产品编号 CFN99104
    CAS编号 136085-37-5
    分子式 = 分子量 C20H28O8 = 396.43
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Miscellaneous
    植物来源 The roots of Codonopsis pilosula.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    党参炔苷 CFN99104 136085-37-5 10mg QQ客服:215959384
    党参炔苷 CFN99104 136085-37-5 20mg QQ客服:215959384
    党参炔苷 CFN99104 136085-37-5 50mg QQ客服:215959384
    党参炔苷 CFN99104 136085-37-5 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Amsterdam (Netherlands)
  • Georgia Institute of Technology (USA)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Donald Danforth Plant Science Center (USA)
  • Helmholtz Zentrum München (Germany)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Sri Ramachandra University (India)
  • Universidade Federal de Santa Catarina (Brazil)
  • Kyung Hee University (Korea)
  • Pennsylvania State University (USA)
  • Lund University (Sweden)
  • University of Auckland (New Zealand)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Mahidol University (Thailand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2014, 14:242
  • Scientific World Journal.2014, 2014:654193
  • New Zealand J. Forestry Sci.2014, 44:17
  • Chem Biol Interact.2016, 258:59-68
  • Int J Mol Med.2016, 37(2):501-8
  • Nat Prod Commun.2017, 12(5):771-778
  • International. J. of Food Properties 2017, 20:S131-S140
  • Front Plant Sci.2017, 8:723
  • Industrial Crops and Products2017, 95:286-295
  • Front Aging Neurosci.2018, 10:269
  • J of Engineering Science&Technology2018, 13(9):2820-2828
  • Food Chem.2018, 252:207-214
  • Biosci Rep.2018, 38(4)
  • Phytomedicine.2018, 47:48-57
  • Virulence.2018, 9(1):588-603
  • Wageningen University & Research2018, January 2018
  • Chem Biol Interact.2019, 298:1-7
  • Journal of Oil Palm Research2019, 31(2):238-247
  • Pak J Pharm Sci.2019, 32(6)
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • J of Ana. Chem.2019, 74(11):1113-1121
  • Sci Rep.2019, 9:19059
  • Evid-Based Compl Alt2020, 7202519:13
  • ...
  • 生物活性
    Description: Lobetyolin has a protective role in gastric mucosa injury, and the mechanism may be relate to the increase in level of 6-K-PGF1αand the inhibition the excretion of gastric acid and EGF. Lobetyolin inhibits the gene expression of MUC5AC mucin induced by PMA.
    Targets: EGFR
    In vitro:
    Tuberc Respir Dis (Seoul). 2014 Nov;77(5):203-8.
    Effects of Lobetyolin, Lobetyol and Methyl linoleate on Secretion, Production and Gene Expression of MUC5AC Mucin from Airway Epithelial Cells.[Pubmed: 25473407]
    In this study, we investigated whether lobetyolin, lobetyol, and methyl linoleate derived from Codonopsis pilosula affect MUC5AC mucin secretion, production, and gene expression from airway epithelial cells.
    METHODS AND RESULTS:
    Confluent NCI-H292 cells were pretreated with lobetyolin, lobetyol, or methyl linoleate for 30 minutes and then stimulated with phorbol 12-myristate 13-acetate (PMA) for 24 hours. The MUC5AC mucin gene expression, and mucin protein production and secretion were measured by reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. Lobetyolin, lobetyol, and methyl linoleate inhibited the gene expression of MUC5AC mucin induced by PMA; lobetyolin did not affect PMA-induced MUC5AC mucin production. However, lobetyol and methyl linoleate inhibited the production of MUC5AC mucin; lobetyolin and lobetyol did not significantly affect PMA-induced MUC5AC mucin secretion from NCI-H292 cells. However, methyl linoleate decreased the MUC5AC mucin secretion.
    CONCLUSIONS:
    These results suggest that among the three compounds, methyl linoleate can regulate gene expression, production, and secretion of MUC5AC mucin by directly acting on the airway epithelial cells.
    In vivo:
    Journal of Emergency in Traditional Chinese Medicine, 2008, 17(7):963-4.
    Protective Effect of Lobetyolin on Gastric Mucosa of Experimental Gastric Ulcer in Rats[Reference: WebLink]
    To study the protective effect of Lobetyolin on gastric mucosa of experimental gastric ulcer induced by ethanol in rats.
    METHODS AND RESULTS:
    The gastric ulcer model was established in rats by inducing ethanol.The index of ulcer was measured;the levels of Gas and 6-K-PGF1αwere examined by the method of radioimmunity;the level of EGF was measured by ELISA.As compared with model group,in Lobetyolin small dose group,the index of ulcer was markedly decreased,the level of Gas was decreased while the level of 6-K-PGF1αwas increased.In the degree,the level of EGF was increased.
    CONCLUSIONS:
    Lobetyolin has a protective role in gastric mucosa injury,and the mechanism may be relate to the increase in level of 6-K-PGF1αand the inhibition the excretion of gastric acid and EGF.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5225 mL 12.6126 mL 25.2251 mL 50.4503 mL 63.0628 mL
    5 mM 0.5045 mL 2.5225 mL 5.045 mL 10.0901 mL 12.6126 mL
    10 mM 0.2523 mL 1.2613 mL 2.5225 mL 5.045 mL 6.3063 mL
    50 mM 0.0505 mL 0.2523 mL 0.5045 mL 1.009 mL 1.2613 mL
    100 mM 0.0252 mL 0.1261 mL 0.2523 mL 0.5045 mL 0.6306 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    人参炔K; Ginsenoyne K CFN96044 141947-42-4 C17H24O3 = 276.4 5mg QQ客服:1413575084
    党参炔醇; Lobetyol CFN92356 136171-87-4 C14H18O3 = 234.3 5mg QQ客服:2159513211
    党参炔苷; Lobetyolin CFN99104 136085-37-5 C20H28O8 = 396.43 20mg QQ客服:2932563308
    Lobetyolinin; Lobetyolinin CFN92357 142451-48-7 C26H38O13 = 558.6 5mg QQ客服:2932563308
    (3E,5E,11E)-tridecatriene-7,9-diyne-1,2-diacetate; (3E,5E,11E)-tridecatriene-7,9-diyne-1,2-diacetate CFN95191 N/A C17H18O4 = 286.3 5mg QQ客服:1413575084
    11-羟基茉莉酸; 11-Hydroxyjasmonic acid CFN99457 140447-14-9 C12H18O4 = 226.3 5mg QQ客服:1148253675
    12-羟基茉莉酸; 12-Hydroxyjasmonic acid CFN99460 140631-27-2 C12H18O4 = 226.3 5mg QQ客服:2932563308
    (R,E)-癸-2-烯-4,6-二炔-1,8-二醇; (R,E)-Deca-2-ene-4,6-diyne-1,8-diol CFN97502 931116-24-4 C10H12O2 = 164.2 5mg QQ客服:2932563308
    人参环氧炔醇; Panaxydol CFN92797 72800-72-7 C17H24O2 = 260.4 20mg QQ客服:2932563308
    1,8-十七碳二烯-4,6-二炔-3,10-二醇; Panaxydiol CFN92798 708257-91-4 C17H24O2 = 260.4 5mg QQ客服:2932563308

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