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  • 镰叶芹醇

    Falcarinol

    镰叶芹醇
    产品编号 CFN96027
    CAS编号 21852-80-2
    分子式 = 分子量 C17H24O = 244.4
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Miscellaneous
    植物来源 The roots of Saposhnikovia divaricata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    镰叶芹醇 CFN96027 21852-80-2 10mg QQ客服:2159513211
    镰叶芹醇 CFN96027 21852-80-2 20mg QQ客服:2159513211
    镰叶芹醇 CFN96027 21852-80-2 50mg QQ客服:2159513211
    镰叶芹醇 CFN96027 21852-80-2 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Bordeaux (France)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Kitasato University (Japan)
  • Universidad de Buenos Aires (Argentina)
  • University of Fribourg (Switzerland)
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  • University of Illinois (USA)
  • Kazusa DNA Research Institute (Japan)
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  • Pennsylvania State University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Foods.2020, 9(10):1348.
  • Int J Mol Sci.2022, 23(21):12816.
  • Food Funct.2021, 12(4):1469-1481.
  • Food Chemistry2023, 137837.
  • Neurochem Int.2018, 121:114-124
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • J Ethnopharmacol.2019, 228:132-141
  • Oncol Rep.2019, 41(4):2453-2463
  • Plants (Basel).2021, 10(7):1376.
  • Pharmaceutics.2022, 14(12):2765.
  • J Pharmaceutical Research Int.2021, 33(41A):275-284.
  • Food Science&Tech. Res.2022, 28(2):123-132.
  • bioRxiv - Biochemistry2023, 548213.
  • An Acad Bras Cienc.2023, 95(3):e20220672
  • Med Sci Monit.2019, 25:9499-9508
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Mol Cells.2018, 41(8):771-780
  • Fitoterapia.2022, 105141.
  • Vietnam Journal of Science2022, 64(2), 69-75.
  • J Biomol Struct Dyn.2022, 5;1-17.
  • Microb Pathog.2019, 131:128-134
  • Fermentation2023, 9(10), 889
  • Cell Mol Biol(Noisy-le-grand)2019, 65(7):77-83
  • ...
  • 生物活性
    Description: Falcarinol has effects on CaCo-2 cells appear to be biphasic, inducing pro-proliferative and apoptotic characteristics at low and high concentrations of Falcarinol, respectively. Falcarinol-associated dermatitis is due to antagonism of the CB(1) receptor in keratinocytes, leading to increased chemokine expression and aggravation of histamine action.
    Targets: IL Receptor | TNF-α | Caspase
    In vitro:
    Biochem Pharmacol. 2010 Jun 15;79(12):1815-26.
    Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin.[Pubmed: 20206138]
    The skin irritant polyyne Falcarinol (panaxynol, carotatoxin) is found in carrots, parsley, celery, and in the medicinal plant Panax ginseng.
    METHODS AND RESULTS:
    In our ongoing search for new cannabinoid (CB) receptor ligands we have isolated Falcarinol from the endemic Sardinian plant Seseli praecox. We show that Falcarinol exhibits binding affinity to both human CB receptors but selectively alkylates the anandamide binding site in the CB(1) receptor (K(i)=594nM), acting as covalent inverse agonist in CB(1) receptor-transfected CHO cells. Given the inherent instability of purified Falcarinol we repeatedly isolated this compound for biological characterization and one new polyyne was characterized. In human HaCaT keratinocytes Falcarinol increased the expression of the pro-allergic chemokines IL-8 and CCL2/MCP-1 in a CB(1) receptor-dependent manner. Moreover, Falcarinol inhibited the effects of anandamide on TNF-alpha stimulated keratinocytes. In vivo, Falcarinol strongly aggravated histamine-induced oedema reactions in skin prick tests. Both effects were also obtained with the CB(1) receptor inverse agonist rimonabant, thus indicating the potential role of the CB(1) receptor in skin immunopharmacology.
    CONCLUSIONS:
    Our data suggest anti-allergic effects of anandamide and that Falcarinol-associated dermatitis is due to antagonism of the CB(1) receptor in keratinocytes, leading to increased chemokine expression and aggravation of histamine action.
    Cancer Lett . 2018 Jan 1;412:297-307.
    Panaxynol, a natural Hsp90 inhibitor, effectively targets both lung cancer stem and non-stem cells[Pubmed: 29061506]
    Abstract Cancer stem-like cells (CSCs) contribute to tumor recurrence and chemoresistance. Hence, strategies targeting CSCs are crucial for effective anticancer therapies. Here, we demonstrate the capacities of the non-saponin fraction of Panax ginseng and its active principle panaxynol to inhibit Hsp90 function and viability of both non-CSC and CSC populations of NSCLC in vitro and in vivo. Panaxynol inhibited the sphere forming ability of NSCLC CSCs at nanomolar concentrations, and micromolar concentrations of panaxynol suppressed the viability of NSCLC cells (non-CSCs) and their sublines carrying acquired chemoresistance with minimal effect on normal cells derived from various organs. Orally administered panaxynol significantly reduced lung tumorigenesis in KrasG12D/+ transgenic mice and mice carrying NSCLC xenografts without detectable toxicity. Mechanistically, panaxynol disrupted Hsp90 function by binding to the N-terminal and C-terminal ATP-binding pockets of Hsp90 without increasing Hsp70 expression. These data suggest the potential of panaxynol as a natural Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Keywords: Cancer stem cells; Heat shock protein; Lung cancer; Panaxynol.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0917 mL 20.4583 mL 40.9165 mL 81.8331 mL 102.2913 mL
    5 mM 0.8183 mL 4.0917 mL 8.1833 mL 16.3666 mL 20.4583 mL
    10 mM 0.4092 mL 2.0458 mL 4.0917 mL 8.1833 mL 10.2291 mL
    50 mM 0.0818 mL 0.4092 mL 0.8183 mL 1.6367 mL 2.0458 mL
    100 mM 0.0409 mL 0.2046 mL 0.4092 mL 0.8183 mL 1.0229 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (R,E)-癸-2-烯-4,6-二炔-1,8-二醇; (R,E)-Deca-2-ene-4,6-diyne-1,8-diol CFN97502 931116-24-4 C10H12O2 = 164.2 5mg QQ客服:215959384
    人参环氧炔醇; Panaxydol CFN92797 72800-72-7 C17H24O2 = 260.4 20mg QQ客服:215959384
    人参炔二醇; Panaxydiol CFN92798 63910-76-9 C17H24O2 = 260.4 10 mg QQ客服:2159513211
    人参炔三醇; Panaxytriol CFN95665 87005-03-6 C17H26O3 = 278.4 10mg QQ客服:2056216494
    人参炔醇; Panaxyne CFN96202 122855-49-6 C14H20O2 = 220.3 5mg QQ客服:215959384
    1,9-十五碳二烯-4,6-二炔-3,8-二醇8-乙酸酯; 8-Acetoxypentadeca-1,9Z-diene-4,6-diyn-3-ol CFN97743 41682-30-8 C17H22O3 = 274.36 5mg QQ客服:2159513211
    9,17-十八碳二烯-12,14-二炔-1,11,16-三醇; 9,17-Octadecadiene-12,14-diyne-1,11,16-triol CFN98061 211238-60-7 C18H26O3 = 290.4 5mg QQ客服:3257982914
    1-乙酰氧基-9,17-十八碳二烯-12,14-二炔-11,16-二醇; 1-Acetoxy-9,17-octadecadiene-12,14-diyne-11,16-diol CFN98068 213905-35-2 C20H28O4 = 332.4 5mg QQ客服:1413575084
    人参炔醇; Panaxynol CFN93212 81203-57-8 C17H24O = 244.4 5mg QQ客服:215959384
    镰叶芹二醇; Falcarindiol CFN98220 225110-25-8 C17H24O2 = 260.4 20mg QQ客服:2056216494

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