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  • 紫草氰苷

    Lithospermoside

    紫草氰苷
    产品编号 CFN99780
    CAS编号 63492-69-3
    分子式 = 分子量 C14H19NO8 = 329.30
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Miscellaneous
    植物来源 The roots of Lithospermum officinale.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    紫草氰苷 CFN99780 63492-69-3 10mg QQ客服:2159513211
    紫草氰苷 CFN99780 63492-69-3 20mg QQ客服:2159513211
    紫草氰苷 CFN99780 63492-69-3 50mg QQ客服:2159513211
    紫草氰苷 CFN99780 63492-69-3 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • The Institute of Cancer Research (United Kingdom)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • University of Padjajaran (Indonesia)
  • Chinese University of Hong Kong (China)
  • Universite de Lille1 (France)
  • Wroclaw Medical University (Poland)
  • The University of Newcastle (Australia)
  • Universit?t Basel (Switzerland)
  • University Medical Center Mainz (Germany)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Medical University of South Carolina (USA)
  • Michigan State University (USA)
  • University of Sao Paulo (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Mol Med Rep.2015, 12(5):7789-95
  • Mediators Inflamm.2016, 2016:7216912
  • Molecules.2016, 21(10)
  • J Exp Bot.2016, 67(12):3777-88
  • Universidade Estadual Paulista2017, 11449
  • Biochem Pharmacol.2017, 130:10-20
  • J Chromatogr A.2017, 1518:46-58
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • Biochem Biophys Res Commun.2017, 482(4):1095-1101
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • Korean J. of Horticultural Sci. & Tech. 2017, 793-804
  • Int. J. of Food Properties2017, S108-S118
  • Nat Prod Commun.2018, 10.1177
  • Sci Adv.2018, 4(10)
  • Arch Biochem Biophys.2018, 644:93-99
  • Clin Transl Oncol.2019, 10.1007
  • Front Microbiol.2019, 10:2806
  • Asian Pac J Cancer Prev.2019, 20(1):65-72
  • Int J Mol Sci.2019, 21(1):E265
  • J Ethnopharmacol.2019, 236:31-41
  • Pak J Pharm Sci.2019, 32(6)
  • Int J Food Sci Nutr.2019, 70(7):825-833
  • Food and Chemical Toxicology2020, 111221
  • ...
  • 生物活性
    Description: Lithospermoside has anti-oxidant,and anti-tumor promoting activities.
    In vitro:
    Nat Prod Res. 2015 Jan 2:1-4.
    Cytotoxic flavonoids and other constituents from the stem bark of Ochna schweinfurthiana.[Pubmed: 25553908]
    Seven flavonoids, hemerocallone (1), 6,7-dimethoxy-3',4'-dimethoxyisoflavone (2), amentoflavone (4), agathisflavone (6), cupressuflavone (8), robustaflavone (9) and epicatechin (10), together with three other compounds, lithospermoside (3), β-D-fructofuranosyl-α-D-glucopyranoside (5) and 3β-O-D-glucopyranosyl-β-stigmasterol (7), were isolated from the ethyl acetate extract of the stem bark of Ochna schweinfurthiana F. Hoffm.
    METHODS AND RESULTS:
    All the compounds were characterised by spectroscopic and mass spectrometric methods, and by comparison with literature data. Cytotoxicity of the extracts and compounds against cervical adenocarcinoma (HeLa) cells was evaluated by MTT assay.
    CONCLUSIONS:
    Compounds 4 and 6 exhibited good cytotoxic activity, with IC50 values of 20.7 and 10.0 μM, respectively.
    Cancer Lett. 1999 Aug 23;143(1):5-13.
    Anti-tumor promoting activity of polyphenols from Cowania mexicana and Coleogyne ramosissima.[Pubmed: 10465331]

    METHODS AND RESULTS:
    Chemical investigation on polyphenol-rich fractions of Cowania mexicana and Coleogyne ramosissima (Rosaceae) which showed significant inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), has led to the characterization of 10 compounds including C-glucosidic ellagitannin monomers and dimers from the former plant, and 17 polyphenols including flavonoid glycosides from the latter. The effects of individual components and their analogues with related structures on the TPA-induced EBV-EA activation were then evaluated. Among the compounds isolated from C. mexicana, two C-glucosidic ellagitannins, alienanin B and stenophyllanin A and a nitrile glucoside (lithospermoside), and among the constituents from C. ramosissima, two flavonoid glycosides, isorhamnetin 3-0-beta-D-glucoside and narcissin were revealed to possess strong inhibitory effects on EVB-EA activation, the potencies of which were either comparable to or stronger than that of a green tea polyphenol, (-)-epigallocatechin gallate.
    CONCLUSIONS:
    These polyphenols except for nitrile glucoside, which was not tested owing to an insufficient amount, were also found to exhibit anti-tumor promoting activity in two-stage mouse skin carcinogenesis using 7,12-dimethylbenz[a]anthracene (DMBA) and TPA.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0367 mL 15.1837 mL 30.3674 mL 60.7349 mL 75.9186 mL
    5 mM 0.6073 mL 3.0367 mL 6.0735 mL 12.147 mL 15.1837 mL
    10 mM 0.3037 mL 1.5184 mL 3.0367 mL 6.0735 mL 7.5919 mL
    50 mM 0.0607 mL 0.3037 mL 0.6073 mL 1.2147 mL 1.5184 mL
    100 mM 0.0304 mL 0.1518 mL 0.3037 mL 0.6073 mL 0.7592 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    蝙蝠葛氰甙元; Coclauril CFN99383 127350-68-9 C8H9NO2 = 151.2 5mg QQ客服:2159513211
    蝙蝠葛氰苷; Menisdaurin CFN90410 67765-58-6 C14H19NO7 = 313.30 10mg QQ客服:2932563308
    5-表紫草氰苷; 5-Epilithospermoside CFN97404 84799-31-5 C14H19NO8 = 329.3 5 mg QQ客服:2932563308
    紫草氰苷; Lithospermoside CFN99780 63492-69-3 C14H19NO8 = 329.30 20mg QQ客服:2932563308
    (2,4-二羟基苯基)乙腈; (2,4-Dihydroxyphenyl)acetonitrile CFN98974 57576-34-8 C8H7NO2 = 149.2 5mg QQ客服:1413575084
    2-(BETA-D-吡喃葡萄糖基氧基)-4-羟基苯乙腈; Ehretioside B CFN99664 156368-84-2 C14H17NO7 = 311.3 5mg QQ客服:3257982914
    对乙烯基苯基O-BETA-D-吡喃葡萄糖苷; p-Vinylphenyl O-beta-D-glucopyranoside CFN97079 62470-46-6 C14H18O6 = 282.3 5mg QQ客服:1148253675
    BETA-D-对乙烯基苯基 6-O-芹糖-BETA-D-呋喃糖基-BETA-D-吡喃葡萄糖苷; p-Vinylphenyl O-[beta-D-apiofuranosyl-(1-6)]-beta-D-glucopyranoside CFN99216 112047-91-3 C19H26O10 = 414.4 5mg QQ客服:215959384
    4-乙烯基苯基2-O-(6-去氧-ALPHA-L-吡喃甘露糖)-BETA-D-吡喃葡萄糖苷; Ptelatoside B CFN97473 90852-99-6 C20H28O10 = 428.4 5mg QQ客服:1148253675

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