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  • 莲心碱

    Liensinine

    莲心碱
    产品编号 CFN99580
    CAS编号 2586-96-1
    分子式 = 分子量 C37H42N2O6 = 610.75
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Alkaloids
    植物来源 The plantule of Nelumbo nucifera Gaertn.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    莲心碱 CFN99580 2586-96-1 10mg QQ客服:2932563308
    莲心碱 CFN99580 2586-96-1 20mg QQ客服:2932563308
    莲心碱 CFN99580 2586-96-1 50mg QQ客服:2932563308
    莲心碱 CFN99580 2586-96-1 100mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Instituto Politécnico de Bragan?a (Portugal)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • University of Wisconsin-Madison (USA)
  • Siksha O Anusandhan University (India)
  • Periyar University (India)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Universidad de Buenos Aires (Argentina)
  • Uniwersytet Gdański (Poland)
  • CSIRO - Agriculture Flagship (Australia)
  • Nanjing University of Chinese Medicine (China)
  • University of Zurich (Switzerland)
  • Osmania University (India)
  • University of Melbourne (Australia)
  • University Medical Center Mainz (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • Molecules.2016, 21(6)
  • HortTechnology2016, 26(6):816-819
  • Jour. of Stored Pro & Postharvest Res.2016, 7(3):32-36
  • Front Pharmacol.2016, 7:460
  • Phytochemistry.2017, 141:162-170
  • Semyung University2017, 149407
  • J Agric Food Chem.2017, 65(13):2670-2676
  • Front Pharmacol.2017, 8:673
  • Food Res Int.2018, 106:909-919
  • Microchemical Journal2018, 137:168-173
  • Pak J Pharm Sci.2018, 31:311-315
  • BMB Rep.2018, 51(5):249-254
  • Nutrients.2019, 11(11):E2694
  • Mol Microbiol.2019, 112(1):317-332
  • BMC Complement Altern Med.2019, 19(1):11
  • Srinagarind Medical Journal2019, 34(1)
  • Korean Journal of Pharmacognosy2019, 50(4):285-290
  • Chemistry of Natural Compounds2019, 55(1):127-130
  • Sci Rep.2019, 9(1):18080
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • Biomolecules.2020, 10(2):E184
  • Antioxidants (Basel).2020, 9(2):E120
  • ...
  • 生物活性
    Description: Liensinine is a human ether-a-go-go-related gene (hERG) inhibitor and a novel autophagy/mitophagy inhibitor, which can antagonize the ventricular arrhythmias. It exerts remarkable effect against thrombosis and possesses strong effect against platelet aggregation and coagulation.
    Targets: P-gp | hERG | Autophagy
    In vitro:
    Zhongguo Zhong Yao Za Zhi. 2013 Jan;38(2):239-44.
    [Effect of berberine, liensinine and neferine on HERG channel expression].[Pubmed: 23672049]
    Immunofluorescence and Western blot methods were adopted for qualitative and quantitative detections of the effect of different concentrations of berberine, liensinine and neferine on the expression of stable transfection in HERG potassium channel in HEK-293 cells, as well as the effect of different concentrations of berberine on protein expression of Ikr channel in cardiac muscular tissues, in order to investigate the anti-arrhythmic mechanism of berberine, liensinine and neferine.
    METHODS AND RESULTS:
    Western blot method was used to detect protein expression of HERG channel in HERG-HEK cells. Immunofluorescence method as well as confocal laser microscope were used to detect the effect of different concentrations of berberine, liensinine and neferine on protein expression of HERG channel. Western blot method was used to detect the effect of different concentrations of berberine on protein expression of Ikr channel in cardiac muscular tissues as well as the effect of berberine, liensinine and neferine on protein expression of stable transfection in HERG potassium channel in HEK-293 cells. Western blot experiment manifested that stable transfection of HEK293 cells containing HERG genes could increase protein expression of HERG channel. Berberine (10, 30 micromol x L(-1)) remarkably inhibited protein expression of HERG channel in HERG-HEK cells (P < 0.01). Berberine (10, 20 mg x kg(-1)) also inhibited protein expression of Ikr channel in rat ventricular tissues (P < 0.05). Liensinine (3, 10, 30 micromol x L(-1)) increased protein expression of HERG channel in HERG-HEK cells (P < 0.05). Neferine showed no effect on protein expression of HERG channel in HERG-HEK cells.
    CONCLUSIONS:
    The stably transfection of HERG-HEK cells can increase protein expression of HERG channel. Berberine shows inhibitory effect on protein expressions of in vitro HERG-HEK cells and Ikr channel in rat ventricular tissues. Liensinine improves protein expression of HERG channe in HERG-HEK cells. Neferine shows no effect on protein expression of HERG channel.
    In vivo:
    Autophagy. 2015;11(8):1259-79.
    A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission.[Pubmed: 26114658]
    Autophagy inhibition has been widely accepted as a promising therapeutic strategy in cancer, while the lack of effective and specific autophagy inhibitors hinders its application.
    METHODS AND RESULTS:
    Here we found that liensinine, a major isoquinoline alkaloid, inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. This effect is likely achieved via inhibiting the recruitment of RAB7A to lysosomes but not to autophagosomes. We further investigated the effects of autophagy inhibition by liensinine on the therapeutic efficacy of chemotherapeutic drugs and found that cotreatment of liensinine markedly decreased the viability and increased apoptosis in breast cancer cells treated with various chemotherapeutic agents. Mechanistically, we found that inhibition of autophagy/mitophagy by liensinine enhanced doxorubicin-mediated apoptosis by triggering mitochondrial fission, which resulted from dephosphorylation and mitochondrial translocation of DNM1L. However, blocking autophagosome/mitophagosome formation by pharmacological or genetic approaches markedly attenuated mitochondrial fission and apoptosis in cells with combinatatorial treatment. Moreover, liensinine was synergized with doxorubicin to inhibit tumor growth in MDA-MB-231 xenograft in vivo.
    CONCLUSIONS:
    Our findings suggest that liensinine could potentially be further developed as a novel autophagy/mitophagy inhibitor, and a combination of liensinine with classical chemotherapeutic drugs could represent a novel therapeutic strategy for treatment of breast cancer.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6373 mL 8.1867 mL 16.3733 mL 32.7466 mL 40.9333 mL
    5 mM 0.3275 mL 1.6373 mL 3.2747 mL 6.5493 mL 8.1867 mL
    10 mM 0.1637 mL 0.8187 mL 1.6373 mL 3.2747 mL 4.0933 mL
    50 mM 0.0327 mL 0.1637 mL 0.3275 mL 0.6549 mL 0.8187 mL
    100 mM 0.0164 mL 0.0819 mL 0.1637 mL 0.3275 mL 0.4093 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异莲心碱; Isoliensinine CFN99574 6817-41-0 C37H42N2O6 = 610.75 20mg QQ客服:2159513211
    莲心碱高氯酸盐; Liensinine perchlorate CFN99578 2385-63-9 C37H42N2O6.ClHO4 = 711.20 20mg QQ客服:215959384
    莲心碱二高氯酸盐; Liensinine diperchlorate CFN99579 5088-90-4 C37H42N2O6.(HClO4)2 = 811.67 20mg QQ客服:2159513211
    莲心碱; Liensinine CFN99580 2586-96-1 C37H42N2O6 = 610.75 20mg QQ客服:1148253675
    甲基莲心碱; Neferine CFN99581 2292-16-2 C38H44N2O6 = 624.77 20mg QQ客服:1148253675
    蝙蝠葛苏林碱; Daurisoline CFN90534 70553-76-3 C37H42N2O6 = 610.73 20mg QQ客服:3257982914
    去甲山豆根碱 B; 蝙蝠葛诺林碱; Daurinoline CFN90601 2831-75-6 C37H42N2O6 = 610.7 20mg QQ客服:1413575084
    蝙蝠葛碱; Dauricine CFN98129 524-17-4 C38H44N2O6 = 624.77 20mg QQ客服:1413575084
    Thalirugidine; Thalirugidine CFN89429 64215-95-8 C39H46N2O8 = 670.79 5mg QQ客服:1148253675
    盐酸吐根碱; Emetine Hydrochloride CFN90334 14198-59-5 C29H41ClN2O4 = 517.1 5mg QQ客服:1413575084

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