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  • 狭叶依瓦菊素

    Ivangustin

    狭叶依瓦菊素
    产品编号 CFN92599
    CAS编号 14164-59-1
    分子式 = 分子量 C15H20O3 = 248.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The roots of Inula helenium L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    狭叶依瓦菊素 CFN92599 14164-59-1 1mg QQ客服:1413575084
    狭叶依瓦菊素 CFN92599 14164-59-1 5mg QQ客服:1413575084
    狭叶依瓦菊素 CFN92599 14164-59-1 10mg QQ客服:1413575084
    狭叶依瓦菊素 CFN92599 14164-59-1 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Rio de Janeiro State University (Brazil)
  • Charles Sturt University (Denmark)
  • Wageningen University (Netherlands)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Weizmann Institute of Science (Israel)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Sri Ramachandra University (India)
  • Aveiro University (Portugal)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Subang Jaya Medical Centre (Malaysia)
  • Biotech R&D Institute (USA)
  • VIT University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • PLoS One.2015, 10(5):e0127060
  • J Ethnopharmacol.2019, 241:112025
  • Int Immunopharmacol.2021, 100:108073.
  • J. Food Composition and Anal.2022, V 109:104482.
  • J Microbiol Biotechnol.2022, 32(2):141-148.
  • Front Microbiol.2022, 13:835463.
  • J Pharm Biomed Anal.2018, 151:32-41
  • Gene.2022, 815:146178.
  • Biomolecules.2020, 10(6):925.
  • Chemistry of Natural Compounds2019, 55(1):127-130
  • BMC Complement Altern Med.2017, 17(1):393
  • Curr Eye Res.2018, 43(1):27-34
  • Food Chem.2016, 191:81-90
  • Int J Cosmet Sci.2022, doi:10.1111/ics.12827.
  • Phytomedicine.2021, 2(82):153452
  • Antioxidants (Basel).2020, 9(4):284.
  • Molecules.2015, 20(10):19172-88
  • Molecules.2017, 22(2)
  • J Plant Biotechnol.2023, 50:070-075.
  • Molecules.2019, 24(21):E3834
  • Nutrients.2019, 12(1)
  • Jour. of Stored Pro & Postharvest Res.2016, 7(3):32-36
  • Int J Mol Sci.2019, 20(14):E3538
  • ...
  • 生物活性
    Description: Ivangustin exhibits remarkable cytotoxicity against HEp2, SGC-7901 and HCT116 human cancer cell lines.
    Targets: PARP
    In vitro:
    Eur J Med Chem. 2015 Aug 1;102:256-265.
    Synthesis, cytotoxicity and inhibition of NO production of ivangustin enantiomer analogues.[Pubmed: 26280922]

    METHODS AND RESULTS:
    The eight novel ivangustin enantiomer analogues possessing α-methylene-γ-butyrolactone moiety have been synthesized using (4S6R, 4S6S)-4-tert-butyldimethylsilyloxy-6-methylcyclohex-2-en-1-one (1) as starting material. These transformations were mainly carried out by aldol condensation reaction and one-pot annelation procedure. The stereochemistry of these synthesized analogues was determined by NOE analysis. Their cytoxicity was evaluated against the human cancer cell lines HCT-116 (colon), HL-60 (leukemia), QGY-7701 (liver), SMMC-7721 (liver), A549 (lung), MCF-7 (breast). The results showed that these analogues were more selective against the cell lines HL-60 and QGY-7701. Analogue 17 exhibited potent cytotoxicity and high selectivity toward HL-60 cell line with IC50 value of 1.02 μM, which suggested that it might be a promising anti-cancer lead compound. The inhibitory activities against NO production and the cytotoxicities in RAW 264.7 macrophages were determined at the same time.
    CONCLUSIONS:
    All of the analogues significantly inhibited the NO production with IC50 value in the range of 3.44-6.99 μM. Analogues 17, 22, 23 and 7 showed higher cytotoxicities, indicated their inhibitory activities against NO production may be influenced by the cytotoxicities.
    Nat. Prod. Commun.,2016,11(1):7-10.
    Cytotoxic and Pro-apoptotic Activities of Sesquiterpene Lactones from Inula britannica.[Pubmed: 26996005]

    METHODS AND RESULTS:
    In this study, five known sesquiterpene lactones (STL) with an α-methylene-γ-lactone motif, including two eudesmanolides, 1β-hydroxyalantolactone (1) and Ivangustin (2), and three 1,10-seco-eudesmanolides, 1-O-acetylbritannilactone (3), 1,6-O,O-diacetylbritannilactone (4), and 6α-O-(2- methylbutyryl)britannilactone (5) were isolated from the flower heads of the medicinal plant Inula britannica. Their structures were characterized by spectroscopic methods. X-ray data of 2 is reported for the first time. Among them, eudesmanolides 1 and 2 exhibited remarkable cytotoxicity against HEp2, SGC-7901 and HCT116 human cancer cell lines, comparable with etoposide (Vp-16) used as reference drug. Furthermore, treatment of HEp2 cells with 1 induced apoptosis associated with cleaved procaspase-3 and PARP.
    CONCLUSIONS:
    The biological assays carried out with normal cells (CHO) revealed that all sesquiterpenes were weakly selective against the cancer cell lines tested.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0274 mL 20.1369 mL 40.2739 mL 80.5477 mL 100.6847 mL
    5 mM 0.8055 mL 4.0274 mL 8.0548 mL 16.1095 mL 20.1369 mL
    10 mM 0.4027 mL 2.0137 mL 4.0274 mL 8.0548 mL 10.0685 mL
    50 mM 0.0805 mL 0.4027 mL 0.8055 mL 1.611 mL 2.0137 mL
    100 mM 0.0403 mL 0.2014 mL 0.4027 mL 0.8055 mL 1.0068 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    别土木香内酯; Alloalantolactone CFN91880 64340-41-6 C15H20O2 = 232.32 10mg QQ客服:1457312923
    狭叶依瓦菊素; Ivangustin CFN92599 14164-59-1 C15H20O3 = 248.3 10mg QQ客服:3257982914
    土木香内酯; Alantolactone CFN99934 546-43-0 C15H20O2 = 232.32 20mg QQ客服:215959384
    1beta-羟基土木香内酯; 1beta-Hydroxyalantolactone CFN92600 68776-47-6 C15H20O3 = 248.3 10mg QQ客服:215959384
    异土木香内酯; Isoalantolactone CFN98107 470-17-7 C16H20O2 = 232.32 20mg QQ客服:2056216494
    11,13-二氢依瓦菊林; 11,13-Dihydroivalin CFN97819 150150-61-1 C15H22O3 = 250.34 5mg QQ客服:1413575084

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