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  • 异肥皂草苷

    Isosaponarin

    异肥皂草苷
    产品编号 CFN90133
    CAS编号 19416-87-6
    分子式 = 分子量 C27H30O15 = 594.52
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The seeds of Vaccaria segetalis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异肥皂草苷 CFN90133 19416-87-6 1mg QQ客服:215959384
    异肥皂草苷 CFN90133 19416-87-6 5mg QQ客服:215959384
    异肥皂草苷 CFN90133 19416-87-6 10mg QQ客服:215959384
    异肥皂草苷 CFN90133 19416-87-6 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Maryland (USA)
  • University of Pretoria (South Africa)
  • Macau University of Science and Technology (China)
  • Universidade de Franca (Brazil)
  • Almansora University (Egypt)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Wageningen University (Netherlands)
  • University of Otago (New Zealand)
  • Sri Ramachandra University (India)
  • University of Beira Interior (Portugal)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Melbourne University (Australia)
  • Universidade Católica Portuguesa (Portugal)
  • Osmania University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nat Prod Sci.2014, 20(3):182-190
  • Int J Mol Sci.2015, 16(1):1232-51
  • Korean Journal of Pharmacognosy.2015, 46(4):352-364
  • J Chromatogr Sci.2015, 53(5):824-9
  • Bulletin of Health Research2016, 44(4):279-286
  • J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
  • Acta horticulturae2017, 1158:257-268
  • Phytochemistry.2017, 141:162-170
  • Research on Crops.2017, 18(3):569
  • J Food Compos Anal2017, 62:197-204
  • Sci Rep.2017, 7:40345
  • J Nat Prod.2017, 80(4):854-863
  • Nutrients.2018, 11(1):E17
  • Int J Mol Sci.2018, 19(9):E2681
  • Wageningen University & Research2018, January 2018
  • Phytother Res.2019, 10.1002
  • J Med Food.2019, 22(10):1067-1077
  • Exp Biol Med (Maywood).2019, 244(16):1463-1474
  • Phytother Res.2019, 33(5):1490-1500
  • Kor. J. Herbol.2019, 34(2):59-66
  • Toxicol In Vitro.2019, 59:161-178
  • Biomolecules.2020, 10(2):E184
  • Food Analytical Methods2020, 1-10
  • ...
  • 生物活性
    Description: Isosaponarin increases collagen synthesis in human fibroblasts, causes by up-regulated TbetaR-II and P4H production.
    Targets: TGF-β/Smad
    In vitro:
    J Nat Med. 2010 Jul;64(3):305-12.
    The effect of isosaponarin isolated from wasabi leaf on collagen synthesis in human fibroblasts and its underlying mechanism.[Pubmed: 20349148 ]
    Wasabi has been used as an important spice in Japanese foods. The wasabi leaves were used as a cosmetic material, but its biological activities have not yet been examined.
    METHODS AND RESULTS:
    We investigated the effect of Isosaponarin derived from wasabi leaf on collagen synthesis in human fibroblasts. The production of type I collagen in human fibroblasts was increased with treatment of wasabi leaf extract. Isosaponarin isolated from wasabi leaves belonged to the group of flavone glycoside, and was the key compound in collagen synthesis from the wasabi leaf ingredients. Isosaponarin increased the type I collagen production at the mRNA gene level. The treatment of Isosaponarin did not influence the production of transforming growth factor-beta (TGF-beta) protein, but increased the production of TGF-beta type II receptor (TbetaR-II) protein and TbetaR-II mRNA. Prolyl 4-hydroxylase (P4H) protein and P4H mRNA were increased by treatment with Isosaponarin. Heat shock protein 47 (HSP47) was not increased by treatment with Isosaponarin.
    CONCLUSIONS:
    These results suggested that Isosaponarin increased collagen synthesis in human fibroblasts, caused by up-regulated TbetaR-II and P4H production.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.682 mL 8.4101 mL 16.8203 mL 33.6406 mL 42.0507 mL
    5 mM 0.3364 mL 1.682 mL 3.3641 mL 6.7281 mL 8.4101 mL
    10 mM 0.1682 mL 0.841 mL 1.682 mL 3.3641 mL 4.2051 mL
    50 mM 0.0336 mL 0.1682 mL 0.3364 mL 0.6728 mL 0.841 mL
    100 mM 0.0168 mL 0.0841 mL 0.1682 mL 0.3364 mL 0.4205 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异夏佛塔苷; Isoschaftoside CFN92029 52012-29-0 C26H28O14 = 564.5 20mg QQ客服:2932563308
    维采宁-2; Vicenin -2 CFN92031 23666-13-9 C27H30O15 = 594.5 10mg QQ客服:3257982914
    异牡荆黄素 2''-O-阿拉伯糖苷; Isovitexin 2''-O-arabinoside CFN90943 53382-71-1 C26H28O14 = 564.49 10mg QQ客服:2932563308
    6''-O-乙酰基异牡荆黄素; 6''-O-acetylisovitexin CFN99341 1223097-20-8 C23H22O11 = 474.4 5mg QQ客服:1148253675
    Meloside A; Meloside A CFN90132 60767-80-8 C27H30O15 = 594.52 5mg QQ客服:215959384
    异肥皂草苷; Isosaponarin CFN90133 19416-87-6 C27H30O15 = 594.52 5mg QQ客服:2159513211
    王不留行黄酮苷; Vaccarin CFN90131 53452-16-7 C32H38O19 = 726.64 20mg QQ客服:3257982914
    皂草苷; 皂草黄苷; Saponarin CFN90134 20310-89-8 C27H30O15 = 594.52 5mg QQ客服:2932563308
    当药黄素; Swertisin CFN90621 6991-10-2 C22H22O10 = 446.4 10mg QQ客服:1148253675
    斯皮诺素; Spinosin CFN99600 72063-39-9 C28H32O15 = 608.55 20mg QQ客服:2159513211

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