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  • 异夏佛塔苷

    Isoschaftoside

    异夏佛塔苷
    产品编号 CFN92029
    CAS编号 52012-29-0
    分子式 = 分子量 C26H28O14 = 564.5
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Desmodium styracifolium (Osh.) Merr.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    异夏佛塔苷 CFN92029 52012-29-0 10mg QQ客服:1148253675
    异夏佛塔苷 CFN92029 52012-29-0 20mg QQ客服:1148253675
    异夏佛塔苷 CFN92029 52012-29-0 50mg QQ客服:1148253675
    异夏佛塔苷 CFN92029 52012-29-0 100mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Federal de Santa Catarina (Brazil)
  • Kazusa DNA Research Institute (Japan)
  • Universidade Católica Portuguesa (Portugal)
  • Shanghai Institute of Organic Chemistry (China)
  • University of Toronto (Canada)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Kitasato University (Japan)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Hamdard University (India)
  • John Innes Centre (United Kingdom)
  • University of Wisconsin-Madison (USA)
  • Kyung Hee University (Korea)
  • University of Canterbury (New Zealand)
  • Universidade Federal de Goias (UFG) (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules. 2013, 18(11):14105-21
  • Molecules.2015, 20(10):19172-88
  • Tumour Biol.2015, 36(9):7027-34
  • FEBS Lett.2015, 589(1):182-7
  • Chemistr of plant2016, 2016021195
  • The Korea Journal of Herbology2016, 29-35
  • J Pharm Biomed Anal.2017, 140:274-280
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • J Ethnopharmacol.2017, 206:327-336
  • Phytochemistry Letters2017, 449-455
  • Cytotechnology.2017, 69(5):765-773
  • Neurochem Int.2018, 121:114-124
  • Virulence.2018, 9(1):588-603
  • Biorxiv2019, 10.1101
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • Molecules.2019, 24(19):E3417
  • Int J Oncol.2019, 55(1):320-330
  • Phytomedicine.2019, 56:48-56
  • Oxid Med Cell Longev2020, 12
  • Industrial Crops and Products2020, 146:112186
  • J Pharmaceut Biomed2020, 178:112894
  • J Pharmaceut Biomed2020, 182:113110
  • United States Patent Application2020, 20200038363
  • ...
  • 生物活性
    Description: Isoschaftoside is used as an intercrop due to its allelopathic inhibition of parasitism by Striga hermonthica, an obligate parasitic weed that can devastate the maize crop. Isoschaftoside has anti-tumor, antioxidant, and antimicrobial activities, it also possesses strong nematicidal activity against M. incognita.
    Targets: Antifection
    In vitro:
    Phytochemistry, 2010, 71(8-9):904-908.
    Isoschaftoside, a C-glycosylflavonoid from Desmodium uncinatum root exudate, is an allelochemical against the development of Striga.[Reference: WebLink]

    METHODS AND RESULTS:
    In East African small-holder farming of maize, the cattle forage legume, Desmodium uncinatum is used as an intercrop due to its allelopathic inhibition of parasitism by Striga hermonthica, an obligate parasitic weed that can devastate the maize crop. Bioassay-guided fractionation of the root extract of D. uncinatum revealed isoschaftoside to be the main compound in the most potent fraction inhibiting growth of germinated S. hermonthica radicles. Bioassays repeated with isoschaftoside isolated from a different plant source, Passiflora incarnata, proved it to be a biologically active component.
    CONCLUSIONS:
    Analysis of the root exudates produced by hydroponically grown D. uncinatum showed isoschaftoside to be present in the hydroponic media at biologically active concentrations of 10–100 nM.
    European Food Research and Technology, 2006, 223(1):102-109.
    Phenol content related to antioxidant and antimicrobial activities of Passiflora spp. extracts.[Reference: WebLink]

    METHODS AND RESULTS:
    Methanolic extracts were prepared from different organs of plants from five Passiflora species obtained by zygotic embryo culture and evaluated for their capacity to quench DPPH and ABTS•+ radicals in comparison to that of Trolox, a water soluble vitamin-E analogue. Moreover their antimicrobial activity against E. coli was tested by agar diffusion and turbidity assays. P. nitida, P. foetida, and P. palmeri showed antimicrobial activity. P. nitida and P. palmeri also showed high antioxidant activity. P. tenuifila and P. coriacea demonstrated antioxidant power but not antimicrobial activity. The phenolic content of the different extracts was studied and quantified by spectrophotometric methods, HPLC, and mass spectrometry.
    CONCLUSIONS:
    High antioxidant activity correlated with high amounts of o-diphenol and catechin. An unknown component, tentatively identified as structural isomer of isoschaftoside, appeared to correlate with antimicrobial activity.
    Molecules, 2011, 16(6):5079-5086.
    Nematocidal Flavone-C-Glycosides against the Root-Knot Nematode (Meloidogyne incognita) from Arisaema erubescens Tubers.[Reference: WebLink]

    METHODS AND RESULTS:
    A screening of several Chinese medicinal herbs for nematicidal properties showed that Arisaema erubescens (Wall.) Schott tubers possessed significant nematicidal activity against the root-knot nematode (Meloidogyne incognita). From the ethanol extract, two nematicidal flavone-C-glycosides were isolated by bioassay-guided fractionation.The compounds were identified as schaftoside and isoschaftoside on the basis of their phytochemical and spectral data.
    CONCLUSIONS:
    Schaftoside and isoschaftoside possessed strong nematicidal activity against M. incognita (LC(50) = 114.66 μg/mL and 323.09 μg/mL, respectively) while the crude extract of A. erubescens exhibited nematicidal activity against the root-knot nematode with a LC(50) value of 258.11 μg/mL.
    World Journal of Traditional Chinese Medicine (English), 2018.
    Network Pharmacology-based Study of the Active Constituents of Chinese Medicinal Formulae for Antitumor Mechanism.[Reference: WebLink]
    To investigate the network pharmacology of anti-tumor Chinese medicinal formulae and explain the synergistic mechanism of various active ingredients of Chinese medicinal formulae.
    METHODS AND RESULTS:
    We collected the anti-tumor Chinese medicinal formulae and chose several single herbs with the top frequency for further study. The chemical constituents of these herbs were downloaded from databases CNPC and Traditional Chinese Medicine Systems Pharmacology and were analyzed to set up the anti-tumor material basis. The genes regulated by these constituents were retrieved in Traditional Chinese Medicine integrated database and Comparative Toxicogenomics database. We collected 65 anti-tumor Chinese medicinal formulae, and 4 single herbs were selected, including Licorice, Radix astragali, Panax ginseng, and Radix scutellariae, which consist of 172, 70, 293, and 92 known constituents, respectively. The constituent–gene network, protein–protein interaction network, gene–pathway enrichment network, and gene–disease network were constructed. Moreover, molecular docking was employed to clarify the interactions between active constituents and key drug targets (PTG2, epidermal growth factor receptor, peroxisome proliferator-activated receptor gamma, estrogen receptor 1, mammalian target of rapamycin, AKT1, mitogen-activated protein kinase 1 [MAPK1], peroxisome proliferator-activated receptor alpha, and MAPK8). Most of the constituents could act on multiple targets, whose structures mainly belong to alkaloids, flavonoids, and their glycosides, organic acids, or dianthrone, and their representative chemical constituents include narcissus glycosides, rutin, dauricine, scutellarin, baicalin, isoschaftoside, and leucovorin.
    CONCLUSIONS:
    The network mechanism of the effective constituents from traditional Chinese medicines (TCMs) for anti-tumor therapy was partially uncovered by using statistical methods, network pharmacology methods, and molecular docking methods. This study will provide important information for new drug design with multiple targets for anti-tumor therap.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7715 mL 8.8574 mL 17.7148 mL 35.4296 mL 44.287 mL
    5 mM 0.3543 mL 1.7715 mL 3.543 mL 7.0859 mL 8.8574 mL
    10 mM 0.1771 mL 0.8857 mL 1.7715 mL 3.543 mL 4.4287 mL
    50 mM 0.0354 mL 0.1771 mL 0.3543 mL 0.7086 mL 0.8857 mL
    100 mM 0.0177 mL 0.0886 mL 0.1771 mL 0.3543 mL 0.4429 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异牡荆黄素 2''-O-阿拉伯糖苷; Isovitexin 2''-O-arabinoside CFN90943 53382-71-1 C26H28O14 = 564.49 10mg QQ客服:215959384
    6''-O-乙酰基异牡荆黄素; 6''-O-acetylisovitexin CFN99341 1223097-20-8 C23H22O11 = 474.4 5mg QQ客服:1148253675
    Meloside A; Meloside A CFN90132 60767-80-8 C27H30O15 = 594.52 5mg QQ客服:1148253675
    异肥皂草苷; Isosaponarin CFN90133 19416-87-6 C27H30O15 = 594.52 5mg QQ客服:215959384
    王不留行黄酮苷; Vaccarin CFN90131 53452-16-7 C32H38O19 = 726.64 20mg QQ客服:1148253675
    皂草苷; 皂草黄苷; Saponarin CFN90134 20310-89-8 C27H30O15 = 594.52 5mg QQ客服:1148253675
    当药黄素; Swertisin CFN90621 6991-10-2 C22H22O10 = 446.4 10mg QQ客服:2159513211
    斯皮诺素; Spinosin CFN99600 72063-39-9 C28H32O15 = 608.55 20mg QQ客服:2159513211
    6'''-阿魏酰斯皮诺素; 6'''-Feruloylspinosin CFN90665 77690-92-7 C38H40O18 = 784.71 20mg QQ客服:3257982914
    牡荆素; Vitexin CFN98601 3681-93-4 C21H20O10 = 432.4 20mg QQ客服:3257982914

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