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    异隐丹参酮

    Isocryptotanshinone

    异隐丹参酮
    产品编号 CFN90355
    CAS编号 22550-15-8
    分子式 = 分子量 C19H20O3 = 296.36
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The roots of Salvia miltiorrhiza
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异隐丹参酮 CFN90355 22550-15-8 1mg QQ客服:3257982914
    异隐丹参酮 CFN90355 22550-15-8 5mg QQ客服:3257982914
    异隐丹参酮 CFN90355 22550-15-8 10mg QQ客服:3257982914
    异隐丹参酮 CFN90355 22550-15-8 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Uniwersytet Jagielloński w Krakowie (Poland)
  • National Hellenic Research Foundation (Greece)
  • Imperial College London (United Kingdom)
  • Gyeongsang National University (Korea)
  • Wroclaw Medical University (Poland)
  • Univerzita Karlova v Praze (Czech Republic)
  • Universite Libre de Bruxelles (Belgium)
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  • University of Toulouse (France)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Biol Chem.2014, 289(3):1723-31
  • Mol Med Rep.2015, 12(5):7789-95
  • J Breast Cancer.2015, 18(2):112-118
  • Molecules.2015, 20(10):19172-88
  • Tumour Biol.2015, 36(12):9385-93
  • Polytechnic University of Catalonia2017, 105826
  • International. J. of Food Properties 2017, 20:S131-S140
  • Evid Based Complement Alternat Med.2017, 2017:1583185
  • Front Immunol.2017, 8:1542
  • Plant J.2017, 90(3):535-546
  • Nutrients.2018, 10(10)
  • Neurochem Int.2018, 121:114-124
  • Nutrients.2019, 12(1)
  • APMIS.2019, 127(10):688-695
  • Asian Pac J Cancer Prev.2019, 20(1):65-72
  • Phytomedicine.2019, 57:95-104
  • Food Res Int.2020, 128:108778
  • Metabolites.2020, 10(12):497.
  • Appl. Sci.2020, 10(8),2804
  • SCOPUS.2020, 836-847.
  • Antioxidants (Basel).2020, 9(4):284.
  • Antioxidants (Basel).2020, 9(6):544.
  • Molecules.2021, 26(2):E255.
  • ...
  • 生物活性
    Description: Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes.
    Targets: STAT | JNK | ERK | p38MAPK | PTP1B
    In vitro:
    J Breast Cancer. 2015 Jun; 18(2): 112–118.
    Isocryptotanshinone Induced Apoptosis and Activated MAPK Signaling in Human Breast Cancer MCF-7 Cells.[Pubmed: 26155286]
    Isocryptotanshinone (ICTS) is a natural bioactive product that is isolated from the roots of the widely used medical herb Salvia miltiorrhiza. However, few reports exist on the mechanisms underlying the therapeutic effects of ICTS. Here, we report that ICTS has anticancer activity and describe the mechanism underlying this effect.
    METHODS AND RESULTS:
    The antiproliferative effect of ICTS was determined using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) and clonogenic assays. The effect of ICTS on the cell cycle was measured using flow cytometry. Apoptosis was determined by Hoechst 33342 staining, DNA fragmentation assays, and Western blotting for apoptotic proteins. Finally, the effect of ICTS on mitogen-activated protein kinases (MAPKs) was determined by Western blotting. ICTS significantly inhibited proliferation of MCF-7 and MDA-MB-231 human breast cancer cells, HepG2 human liver cancer cells, and A549 human lung cancer cells in vitro. Among the tested cell lines, MCF-7 cells showed the highest sensitivity to ICTS. ICTS significantly inhibited colony formation by MCF-7 cells. Furthermore, exposure of MCF-7 cells to ICTS induced cell cycle arrest at the G1 phase and decreased mitochondrial membrane potential. Hoechst 33342 staining and Western blot analysis for apoptotic proteins suggested that ICTS induced apoptosis in MCF-7 cells. In addition, ICTS activated MAPK signaling in MCF-7 cells by inducing time- and concentration-dependent phosphorylation of JNK, ERK, and p38 MAPK.
    CONCLUSIONS:
    Our results suggest that ICTS inhibited MCF-7 cell proliferation by inducing apoptosis and activating MAPK signaling pathways.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3743 mL 16.8714 mL 33.7427 mL 67.4855 mL 84.3569 mL
    5 mM 0.6749 mL 3.3743 mL 6.7485 mL 13.4971 mL 16.8714 mL
    10 mM 0.3374 mL 1.6871 mL 3.3743 mL 6.7485 mL 8.4357 mL
    50 mM 0.0675 mL 0.3374 mL 0.6749 mL 1.3497 mL 1.6871 mL
    100 mM 0.0337 mL 0.1687 mL 0.3374 mL 0.6749 mL 0.8436 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    丹参新醌C; Danshenxinkun C CFN90327 65907-77-9 C16H12O3 = 252.3 5mg QQ客服:2056216494
    丹参新醌B; Danshenxinkun B CFN90326 65907-76-8 C18H16O3 = 280.3 5mg QQ客服:3257982914
    丹参新醌A; Danshenxinkun A CFN90325 65907-75-7 C18H16O4 = 296.32 5mg QQ客服:2932563308
    丹参新醌D; Danshenxinkun D CFN90328 98873-76-8 C21H20O4 = 336.38 5mg QQ客服:1457312923
    二氢异丹参酮I; Dihydroisotanshinone I CFN90162 20958-18-3 C18H14O3 = 278.30 10mg QQ客服:1457312923
    异隐丹参酮; Isocryptotanshinone CFN90355 22550-15-8 C19H20O3 = 296.36 5mg QQ客服:2159513211
    异丹参酮I; Isotanshinone I CFN90356 20958-17-2 C18H12O3 = 276.29 5mg QQ客服:1457312923
    异丹参酮IIA; Isotanshinone IIA CFN90357 20958-15-0 C19H18O3 = 294.35 5mg QQ客服:1413575084

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