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  • 去水淫羊藿黄素; 脱水淫羊藿素

    Icaritin

    去水淫羊藿黄素; 脱水淫羊藿素
    产品编号 CFN98527
    CAS编号 118525-40-9
    分子式 = 分子量 C21H20O6 = 368.38
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The roots of Epimedium brevicornu Maxim.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    去水淫羊藿黄素; 脱水淫羊藿素 CFN98527 118525-40-9 10mg QQ客服:1148253675
    去水淫羊藿黄素; 脱水淫羊藿素 CFN98527 118525-40-9 20mg QQ客服:1148253675
    去水淫羊藿黄素; 脱水淫羊藿素 CFN98527 118525-40-9 50mg QQ客服:1148253675
    去水淫羊藿黄素; 脱水淫羊藿素 CFN98527 118525-40-9 100mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universitas islam negeri Jakarta (Indonesia)
  • Srinakharinwirot University (Thailand)
  • National Cancer Center Research Institute (Japan)
  • Mahatma Gandhi University (India)
  • University of Illinois (USA)
  • Pennsylvania State University (USA)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • National Cancer Institute (USA)
  • Shanghai Institute of Organic Chemistry (China)
  • University of Madras (India)
  • University of East Anglia (United Kingdom)
  • Siksha O Anusandhan University (India)
  • Heidelberg University (Germany)
  • Kyung Hee University (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules. 2013, 18(7):7376-88
  • Mol Med Rep.2014, 9(5):1653-9
  • Inflammation.2015, 38(4):1502-16
  • Nat Prod Sci.2016, 22(2)
  • The Korea Journal of Herbology2016, 29-35
  • Pharm Biol.2016, 54(7):1255-62
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • University of Central Lancashire2017, 20472
  • Molecules.2017, 22(11)
  • J Nat Med.2017, 71(2):380-388
  • Food Res Int.2017, 96:40-45
  • Int. J. of Food Properties2017, S108-S118
  • Neuropharmacology.2018, 131:68-82
  • Chemistry of Natural Compounds2018, 204–206
  • The Japan Society for Analytical Chemistry2018, 67(4):201-206
  • Nat Commun.2019, 10(1):5169
  • Biomol Ther (Seoul).2019, 10.4062
  • J Pharm Biomed Anal.2019, 164:119-127
  • Food Engineering Progress2019, 23(3)209-216
  • Molecules.2019, 25(1):E103
  • Srinagarind Medical Journal2019, 34(1)
  • TCI CO.2019, US20190151281A1
  • J Pharmaceut Biomed2020, 178:112894
  • ...
  • 生物活性
    Description: Icaritin, a potent inhibitor of transcription factor SREBPs, which exhibits a variety of biological activities, such as activation of cancer cell apoptosis and inhibition of growth, hormone regulation, protection against beta amyloid-induced neurotoxicity, and promotion of neuronal and cardiac cellular differentiation. Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings.
    Targets: IL Receptor | JAK | STAT | Bcl-2/Bax | Caspase | Estrogen receptor | JNK | ERK | Akt | p38MAPK | Bcr-Abl | Beta Amyloid | Progestogen receptor
    In vitro:
    Oncotarget. 2015 Apr 30;6(12):10460-72.
    Icaritin suppresses multiple myeloma, by inhibiting IL-6/JAK2/STAT3.[Pubmed: 25865044]
    Icaritin is an active prenylflavonoid derived from Epimedium genus, a traditional Chinese medicine. Icaritin has a wide range of pharmacological and biological activities, including cardiovascular function improvement, hormone regulation and antitumor activity.
    METHODS AND RESULTS:
    Here, we investigated the effect of icaritin on multiple myeloma (MM) in vitro and in vivo. Icaritin inhibited cell growth of MM cell line and primary MM cells. In contrast, icaritin had low or no cytotoxic effect on normal hematopoiesis. We also demonstrated that in MM xenograft mouse models, icaritin suppressed tumor growth and decreased serum IL-6 and IgE levels, but did not show adverse reactions such as body weight loss. The anti-MM activity of icaritin was mainly mediated by inhibiting IL-6/JAK2/STAT3 signaling.
    CONCLUSIONS:
    We suggest that icaritin can be further tested in clinical trials in MM.
    Eur J Pharmacol. 2004 Nov 19;504(3):147-53.
    Proliferation-stimulating effects of icaritin and desmethylicaritin in MCF-7 cells.[Pubmed: 15541416 ]
    Icariin, Icaritin and desmethylIcaritin are constituents of Epimedium with a similar structure to genistein and daidzein.
    CONCLUSIONS:
    Using the modified MCF-7 cell proliferation assay (E-SCREEN assessment system), these compounds were tested for their estrogen-like activities. Icaritin and desmethylIcaritin, but not icariin, strongly stimulated the proliferation of MCF-7/BUS cells. Cell cycle analysis revealed that the proliferation stimulatory effect was associated with a marked increase in the number of MCF-7/BUS cells in S phase and a significant increase in the G2/M population, with effects similar to those of estradiol. These actions were dose dependent (range from 1 nM to 10 microM) and could be significantly inhibited by the specific estrogen receptor antagonist ICI 182,780 [7 alpha-[9(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl)-estra-1,3,5(10)-triene-3,17beta-diol)]. The estrogen receptor-regulated progesterone receptor and PS2 mRNA levels were increased by treatment with Icaritin or desmethylIcaritin within 24 h and the effects were also reversed by ICI 182,780.
    CONCLUSIONS:
    It was concluded that Icaritin and desmethylIcaritin are novel phytoestrogens and that the estrogenic effects of Icaritin and desmethylIcaritin are mediated by the estrogen receptor.
    Phytomedicine. 2014 Oct 15;21(12):1633-7.
    Synergistic inhibitory effect of Icariside II with Icaritin from Herba Epimedii on pre-osteoclastic RAW264.7 cell growth.[Pubmed: 25442270]
    Increasing evidence shows the therapeutic superiority of herbal extracts in comparison to isolated single constituents. One of the reasons may be attributed to the synergy effect of compound combinations. Flavonoids from Herba Epimedii have been shown to have therapeutic effect against bone loss. Our previous study showed that Icariside II inhibited pre-osteoclast RAW264.7 growth. The aim of this study was to investigate whether the activity of Icariside II is synergized by other components of Herba Epimedii.
    METHODS AND RESULTS:
    The inhibitory activity of Icariside II was significantly enhanced in the presence of the extract of Herba Epimedii (EHE) at the ratio of 1:1, 1:5 and 1:10. Icaritin, another flavonoid constituent, was shown here to inhibit RAW264.7 growth in a dose-dependent manner. Further, we found that Icariside II, together with Icaritin, synergistically inhibited RAW264.7 growth. The synergistic effect is significant when the ratio of Icariside II and Icaritin was 10:1, 5:1, 1:1, 1:2, and 1:5, respectively.
    CONCLUSIONS:
    In conclusion, Icaritin were an active component. The inhibitory activity of Icariside II on pre-osteoclast RAW264.7 growth was synergized by Icaritin, which maybe contribute to the efficiency of Herba Epimedii extract on curing bone-related diseases, such as osteoporosis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7146 mL 13.5729 mL 27.1459 mL 54.2918 mL 67.8647 mL
    5 mM 0.5429 mL 2.7146 mL 5.4292 mL 10.8584 mL 13.5729 mL
    10 mM 0.2715 mL 1.3573 mL 2.7146 mL 5.4292 mL 6.7865 mL
    50 mM 0.0543 mL 0.2715 mL 0.5429 mL 1.0858 mL 1.3573 mL
    100 mM 0.0271 mL 0.1357 mL 0.2715 mL 0.5429 mL 0.6786 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    苦参醇C; Kushenol C CFN92391 99119-73-0 C25H26O7 = 438.5 10mg QQ客服:1413575084
    甘草黄酮醇; Licoflavonol CFN96515 60197-60-6 C20H18O6 = 354.35 5mg QQ客服:1413575084
    黄宝石羽扇豆素; Topazolin CFN96520 109605-79-0 C21H20O6 = 368.39 5mg QQ客服:2159513211
    Cudraflavone B; Cudraflavone B CFN91905 19275-49-1 C25H24O6 = 420.45 5mg QQ客服:2159513211
    去甲淫羊藿黄素; Noricaritin CFN98528 5240-95-9 C20H20O7 = 372.37 20mg QQ客服:3257982914
    槐黄醇; Sophoflavescenol CFN90767 216450-65-6 C21H20O6 = 368.4 5mg QQ客服:2932563308
    异去氢淫羊藿素; Isoanhydroicaritin CFN93597 28610-30-2 C21H20O6 = 368.4 5mg QQ客服:3257982914
    去水淫羊藿黄素; 脱水淫羊藿素; Icaritin CFN98527 118525-40-9 C21H20O6 = 368.38 20mg QQ客服:215959384
    脱水淫羊藿素; Anhydroicaritin CFN98526 38226-86-7 C21H20O6 = 368.38 20mg QQ客服:2159513211
    Citrusinol; Citrusinol CFN91888 112516-43-5 C20H16O6 = 352.34 5mg QQ客服:2932563308

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