野菊花内酯

Handelin

	产品编号	CFN90906
	CAS编号	62687-22-3
	分子式 = 分子量	C₃₂H₄₀O₈ = 552.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The herbs of Dendranthema indicum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
野菊花内酯	CFN90906	62687-22-3	1mg	QQ客服：1413575084
野菊花内酯	CFN90906	62687-22-3	5mg	QQ客服：1413575084
野菊花内酯	CFN90906	62687-22-3	10mg	QQ客服：1413575084
野菊花内酯	CFN90906	62687-22-3	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Sant Gadge Baba Amravati University (India)

Universita' Degli Studi Di Cagliari (Italy)

University Medical Center Mainz (Germany)

Massachusetts General Hospital (USA)

Kitasato University (Japan)

University of Queensland (Australia)

University of Auckland (New Zealand)

Siksha O Anusandhan University (India)

Instituto de Investigaciones Agropecuarias (Chile)

University of Padjajaran (Indonesia)

University of Bordeaux (France)

Cancer Research Initatives Foundation(CARIF) (Malaysia)

Auburn University (USA)

University of the Basque Country (Spain)

More...

Description:

Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.

Targets:

NO | PGE | TNF-α | IL Receptor | NF-kB | MAPK | ERK | JNK | IkB | IKK

In vitro:

Planta Med 2012; 78 - PD86.

Request full-text Anti-inflammatory activity of handelin through the modulation of NF-κB signaling and pro-inflammatory cytokine productions[Reference: WebLink]

Handelin, a guaianolide dimer, is a constituent of the flower of Chrysanthemum boreale Makino (Compositae). C. boreale have been used as traditional medicines for the treatment of vertigo and fever in Asian countries.
METHODS AND RESULTS:
The present study was designed to investigate the anti-inflammatory potential of Handelin in vitro and in vivo. Handelin inhibited LPS-stimulated production of NO and PGE2 in cultured mouse macrophage RAW 264.7 cells. The suppression of NO and PGE2 production by Handelin was correlated with the down-regulation of mRNA and protein expressions of iNOS and COX-2. Further study revealed that Handelin suppressed the induction of pro-inflammatory cytokines including TNF-α and IL-1β as well as microRNA-155 in LPS-induced RAW264.7 cells. Activation of the transcriptional activity of NF-κB by LPS was also alleviated by Handelin, which was well coincided with its inhibitory effect on IκB degradation. In addition, the activation of MAPKs such as ERK and JNK signaling was suppressed by Handelin. In in vivo animal model, oral administration of Handelin inhibited carrageenan-induced paw edema and TPA-induced ear edema, respectively. The analysis of cytokine production in serum showed that Handelin dose-dependently inhibited the production of IL-1β in a carrageenan-induced paw edema.
CONCLUSIONS:
These findings suggest that Handelin might be an active ingredient of C. boreale with the anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
双旋覆花内酯丁; Japonicone D	CFN92708	1078711-42-8	C₃₄H₄₄O₉ = 596.7	5mg	QQ客服：2159513211
Inulanolide A; Inulanolide A	CFN92801	888941-86-4	C₃₄H₄₄O₉ = 596.7	5mg	QQ客服：215959384
洋艾素; Absinthiin	CFN90168	1362-42-1	C₃₀H₄₀O₆ = 496.62	5mg	QQ客服：2056216494
野菊花内酯; Handelin	CFN90906	62687-22-3	C₃₂H₄₀O₈ = 552.7	5mg	QQ客服：3257982914
前五味子素B; Pre-schisanartanin B	CFN99048	1033288-92-4	C₃₁H₄₂O₁₁ = 590.7	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8093 mL	9.0465 mL	18.093 mL	36.186 mL	45.2325 mL
5 mM	0.3619 mL	1.8093 mL	3.6186 mL	7.2372 mL	9.0465 mL
10 mM	0.1809 mL	0.9046 mL	1.8093 mL	3.6186 mL	4.5232 mL
50 mM	0.0362 mL	0.1809 mL	0.3619 mL	0.7237 mL	0.9046 mL
100 mM	0.0181 mL	0.0905 mL	0.1809 mL	0.3619 mL	0.4523 mL