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  • 2,5-二羟基苯甲酸

    Gentisic acid

    2,5-二羟基苯甲酸
    产品编号 CFN92451
    CAS编号 490-79-9
    分子式 = 分子量 C7H6O4 = 154.1
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The roots of Gentiana scabra Bunge.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
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    2,5-二羟基苯甲酸 CFN92451 490-79-9 10mg QQ客服:2932563308
    2,5-二羟基苯甲酸 CFN92451 490-79-9 20mg QQ客服:2932563308
    2,5-二羟基苯甲酸 CFN92451 490-79-9 50mg QQ客服:2932563308
    2,5-二羟基苯甲酸 CFN92451 490-79-9 100mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Beira Interior (Portugal)
  • University of Mysore (India)
  • Subang Jaya Medical Centre (Malaysia)
  • The Institute of Cancer Research (United Kingdom)
  • Shanghai University of TCM (China)
  • Chulalongkorn University (Thailand)
  • Srinakharinwirot University (Thailand)
  • Harvard University (USA)
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  • Yale University (USA)
  • Complutense University of Madrid (Spain)
  • Amity University (India)
  • Monash University Sunway Campus (Malaysia)
  • Tohoku University (Japan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2014, 14:352
  • PLoS One.2015, 10(5):e0127060
  • J Breast Cancer.2015, 18(2):112-118
  • Evid Based Complement Alternat Med.2015, 2015:165457
  • J Med Food.2016, 19(12):1155-1165
  • The Korea Journal of Herbology2016, 29-35
  • J Separation Science & Technology2016, 51:1579-1588
  • J Pharm Anal.2016, 6(6):363-373
  • Mol Immunol. 2016, 78:121-132
  • Org Biomol Chem.2017, 15(31):6483-6492
  • J Ethnopharmacol.2017, 198:91-97
  • University of Central Lancashire2017, 20472
  • Sci Rep.2017, 7(1):3249
  • PLoS One.2018, 13(4):e0195642
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • Phytomedicine.2018, 40:37-47
  • J of the Korean Society of Cosmetics and Cosmetology2019, 225-231
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • Kor. J. Herbol.2019, 34(2):59-66
  • Journal of Third Military Medical University2019, 41(2):110-115
  • Phytomedicine.2019, 65:153089
  • J Pharmaceut Biomed2020, 182:113110
  • Cell Metab.2020, S1550-4131(20)30002-4
  • ...
  • 生物活性
    Description: Gentisic acid, an active metabolite of salicylic acid degradation, has a broad spectrum of biological activity, such as antibiotic, anti-inflammatory, antirheumatic and antioxidant properties; it also has antimutagenic/protective effects that may contribute to human health. Gentisic acid has protective effect against cyclophosphamide induced genotoxicity and hepatotoxicity in Swiss albino mice.
    Targets: LDL | Immunology & Inflammation related
    In vitro:
    Drug Chem Toxicol. 2017 May 16:1-7.
    Cytotoxicity, mutagenicity, and antimutagenicity of the gentisic acid on HTC cells.[Pubmed: 28511592 ]
    Gentisic acid (GA) exhibits antioxidant, anti-inflammatory, and antibiotic activities. This substance can be found in citrus fruits, grapes, olive oil, and peas.
    METHODS AND RESULTS:
    Considering that there are few studies in the literature on the toxicity of GA, the present work aimed to investigate its cytotoxic, mutagenic, and antimutagenic activities on HTC cells. GA was diluted in culture medium at the final concentration of 0.08, 0.16, 0.8, 1.6, and 8 μg/mL. The cytotoxicity was determined by the MTT assay and Trypan Blue exclusion method, with methyl methanesulfonate and doxorubicin as positive controls, respectively. The cytokinesis-block micronucleus assay determined the mutagenic/antimutagenic activity with benzo[a]pyrene as positive control. Negative control received culture medium only. GA (0.08-8 μg/mL) was not cytotoxic to HTC cells by the MTT assay nor the Trypan Blue exclusion method as no statistical difference was observed when compared to the control. Concentration of 0.08 and 0.8 μg/mL showed no mutagenic or clastogenic effects, as no significant micronuclei inductions were observed, different from 8 μg/mL, that was mutagenic. Furthermore, none of the concentrations presented an antiproliferative activity. The antimutagenic activity of GA (0.08 μg/mL) was observed at the simultaneous treatment, as it reduced the frequency of micronuclei by 76% (24 h) and 79% (48 h). Although pre- and post-treatments were not statistically different from the mutagen, they reduced the induced-damage by 11% and 21%, respectively.
    CONCLUSIONS:
    The present study indicated the absence of cytotoxicity and antiproliferative activities of GA, in addition to their antimutagenic/protective effects that may contribute to human health.
    Eur J Pharmacol. 2005 Apr 25;513(3):173-9.
    Gentisic acid, an aspirin metabolite, inhibits oxidation of low-density lipoprotein and the formation of cholesterol ester hydroperoxides in human plasma.[Pubmed: 15862799]
    Gentisic acid, an aspirin metabolite, has an antioxidant effect, although its detailed mechanism remains elusive.
    METHODS AND RESULTS:
    The present study was designed to determine whether it inhibits low-density lipoprotein (LDL) oxidation and the formation of lipid hydroperoxides in human plasma. The susceptibility of LDL oxidative modification was investigated by a method using 2,2'-azobis or Cu2+. To study the effect of gentisic acid on free radical-induced damage to plasma lipids, cholesterol ester hydroperoxides generated by incubating human fresh plasma with Cu2+ and gentisic acid was analyzed. Gentisic acid inhibited LDL oxidation in a concentration-dependent manner. It significantly inhibited the formation of cholesterol ester hydroperoxides in plasma, and was consumed after the depletion of ascorbic acid and reduced form of coenzyme Q-10 (CoQH2-10), whereas concentrations of other antioxidants remained unchanged.
    CONCLUSIONS:
    Gentisic acid had a potent free radical scavenging activity with a minimal chelating effect. The potent antioxidant property of gentisic acid may partly account for the anti-atherogenic effects of aspirin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.4893 mL 32.4465 mL 64.8929 mL 129.7859 mL 162.2323 mL
    5 mM 1.2979 mL 6.4893 mL 12.9786 mL 25.9572 mL 32.4465 mL
    10 mM 0.6489 mL 3.2446 mL 6.4893 mL 12.9786 mL 16.2232 mL
    50 mM 0.1298 mL 0.6489 mL 1.2979 mL 2.5957 mL 3.2446 mL
    100 mM 0.0649 mL 0.3245 mL 0.6489 mL 1.2979 mL 1.6223 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3,4-二甲氧基苯甲酸; 3,4-Dimethoxybenzoic acid CFN97499 93-07-2 C9H10O4 = 182.2 20mg QQ客服:2932563308
    2,5-二羟基苯甲酸; Gentisic acid CFN92451 490-79-9 C7H6O4 = 154.1 20mg QQ客服:2932563308
    Orsellinic acid; Orsellinic acid CFN96277 480-64-8 C8H8O4 = 168.2 5mg QQ客服:1413575084
    3-甲基-4-硝基苯甲酸; 3-Methyl-4-nitrobenzoic acid CFN90115 3113-71-1 C8H7NO4 = 181.15 5mg QQ客服:1148253675
    3,4-二羟基苯乙酮; 3',4'-Dihydroxyacetophenone CFN97903 1197-09-7 C8H8O3 = 152.2 20mg QQ客服:1148253675
    香草醇; Vanillyl alcohol CFN93211 498-00-0 C8H10O3 = 154.17 20mg QQ客服:1148253675
    3,4-二羟基苯乙醇; 2-(3,4-Dihydroxyphenyl)ethanol CFN99076 10597-60-1 C8H10O3 = 154.2 20mg QQ客服:1148253675
    北升麻宁; Cimidahurinine CFN99465 142542-89-0 C14H20O8 = 316.3 5mg QQ客服:1413575084
    3,4-二羟基苯基二醇; 3,4-Dihydroxyphenylglycol CFN98355 28822-73-3 C8H10O4 = 170.2 5mg QQ客服:3257982914
    4-(2-羟基-1-甲氧基乙基)-1,2-苯二酚; 4-(2-Hydroxy-1-methoxyethyl)-1,2-benzenediol CFN98979 577976-26-2 C9H12O4 = 184.2 5mg QQ客服:2932563308

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