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  • 灵芝酸H

    Ganoderic acid H

    灵芝酸H
    产品编号 CFN92056
    CAS编号 98665-19-1
    分子式 = 分子量 C32H44O9 = 572.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝酸H CFN92056 98665-19-1 1mg QQ客服:215959384
    灵芝酸H CFN92056 98665-19-1 5mg QQ客服:215959384
    灵芝酸H CFN92056 98665-19-1 10mg QQ客服:215959384
    灵芝酸H CFN92056 98665-19-1 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Limpopo (South Africa)
  • Copenhagen University (Denmark)
  • Wroclaw Medical University (Poland)
  • Melbourne University (Australia)
  • VIT University (India)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • University of Liège (Belgium)
  • Sapienza University of Rome (Italy)
  • University of Wuerzburg (Germany)
  • Imperial College London (United Kingdom)
  • Mahidol University (Thailand)
  • University of Minnesota (USA)
  • Universidad Veracuzana (Mexico)
  • Max-Planck-Insitut (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmacogn Mag.2015, 11(43):562-6
  • Ind Crops Prod.2015, 67:185-191
  • J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
  • J Pharm Anal.2016, 6(6):363-373
  • Jour. of Stored Pro & Postharvest Res.2016, 7(3):32-36
  • Evid Based Complement Alternat Med.2017, 2017:9764843
  • J of L. Chroma.&Related Tech2017, 252-258
  • Chin. Med.J.Res. Prac.2017, 31(4)
  • Sci Rep. 2017, 8207(7)
  • Sci Rep. 2018, 10590
  • Journal of functional foods2018, 171-182
  • Korean J of Medicinal Crop Science2018, 220-226
  • Korean J. Medicinal Crop Sci.2018, 26(2):148-156
  • Phytomedicine.2018, 40:37-47
  • Biomol Ther (Seoul).2019, 10.4062
  • Nutr Res Pract2019, 13:e45
  • Pak J Pharm Sci.2019, 32(6)
  • Anal Sci.2019, 35(12):1317-1325
  • Chin J Appl. Physiol.2019, 35(3):283-288
  • Journal of Third Military Medical University2019, 41(2):110-115
  • The Malaysian journal of pathology2019, 41(3):243-251
  • J Funct Foods2019, 54:449-456
  • Appl. Sci.2020, 10,1304
  • ...
  • 生物活性
    Description: Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting in the down-regulation of expression of Cdk4.
    Targets: NF-kB | AP-1 | CDK
    In vitro:
    Int J Mol Med. 2008 May;21(5):577-84.
    Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling.[Pubmed: 18425349]
    Structurally related lanostane-type triterpenes, ganoderic acid A, F and H (GA-A, GA-F, Ganoderic acid H), were identified in an oriental medicinal mushroom Ganoderma lucidum.
    METHODS AND RESULTS:
    In the present study we evaluated the effect of GA-A, Ganoderic acid H and GA-F on highly invasive human breast cancer cells. We showed that GA-A and Ganoderic acid H suppressed growth (cell proliferation and colony formation) and invasive behavior (adhesion, migration and invasion) of MDA-MB-231 cells. Our results suggest that GA-A and Ganoderic acid H mediate their biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting in the down-regulation of expression of Cdk4 and the suppression of secretion of uPA, respectively. Furthermore, the activity of ganoderic acids is linked to the hydroxylation in the position 7 and 15 (GA-A) and 3 (Ganoderic acid H) in their triterpene lanostane structure.
    CONCLUSIONS:
    In conclusion, hydroxylated triterpenes from G. lucidum could be promising natural agents for the therapy of invasive breast cancers.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7461 mL 8.7306 mL 17.4611 mL 34.9223 mL 43.6529 mL
    5 mM 0.3492 mL 1.7461 mL 3.4922 mL 6.9845 mL 8.7306 mL
    10 mM 0.1746 mL 0.8731 mL 1.7461 mL 3.4922 mL 4.3653 mL
    50 mM 0.0349 mL 0.1746 mL 0.3492 mL 0.6984 mL 0.8731 mL
    100 mM 0.0175 mL 0.0873 mL 0.1746 mL 0.3492 mL 0.4365 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灵芝酸K; Ganoderic acid K CFN92057 104700-95-0 C32H46O9 = 574.7 5mg QQ客服:215959384
    灵芝酸C6; Ganoderic acid C6 CFN92290 105742-76-5 C30H42O8 = 530.7 10mg QQ客服:1148253675
    灵芝酸C6甲酯; Methyl ganoderate C6 CFN92292 105742-81-2 C31H44O8 = 544.7 5mg QQ客服:215959384
    灵芝酸H; Ganoderic acid H CFN92056 98665-19-1 C32H44O9 = 572.7 5mg QQ客服:215959384
    灵芝酸H甲酯; Methyl ganoderate H CFN92291 98665-11-3 C33H46O9 = 586.7 5mg QQ客服:2932563308
    去乙酰基灵芝酸F; Deacetyl ganoderic acid F CFN90746 100665-44-9 C30H40O8 = 528.6 5mg QQ客服:2159513211
    灵芝酸F; Ganoderic acid F CFN92055 98665-15-7 C32H42O9 = 570.7 5mg QQ客服:2159513211

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