• 中药标准品生产商,产品定制服务
  • 灵芝酸D

    Ganoderic acid D

    产品编号 CFN90292
    CAS编号 108340-60-9
    分子式 = 分子量 C30H42O7 = 514.66
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝酸D CFN90292 108340-60-9 1mg QQ客服:2159513211
    灵芝酸D CFN90292 108340-60-9 5mg QQ客服:2159513211
    灵芝酸D CFN90292 108340-60-9 10mg QQ客服:2159513211
    灵芝酸D CFN90292 108340-60-9 20mg QQ客服:2159513211
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • University of South Australia (Australia)
  • Donald Danforth Plant Science Center (USA)
  • University of Brasilia (Brazil)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Semmelweis Unicersity (Hungary)
  • Monash University (Australia)
  • Wroclaw Medical University (Poland)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • University of Auckland (New Zealand)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Universidad Veracuzana (Mexico)
  • University of the Basque Country (Spain)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Ind Crops Prod.2015, 67:185-191
  • Br J Pharmacol.2016, 173(2):396-410
  • Research on Crops.2017, 18(2)
  • Invest New Drugs.2017, 35(2):166-179
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • J Food Compos Anal2017, 62:197-204
  • Cytotechnology.2017, 69(5):765-773
  • Oncotarget.2017, 9(3):4161-4172
  • Int J Mol Sci.2018, 19(9):E2681
  • Molecules.2018, 23(7):E1817
  • Mol Cells.2018, 41(8):771-780
  • Sci Rep.2018, 8:15059
  • Journal of Ginseng Research2019, 10.1016
  • Biomed Pharmacother.2019, 111:262-269
  • Int J Biol Macromol.2019, 126:653-661
  • Molecules.2019, 24(6):E1177
  • Cell Chem Biol.2019, 26(1):27-34
  • J Food Sci Technol.2019, 56(5):2712-2720
  • Phytomedicine.2019, 62:152962
  • Phytomedicine.2019, 65:153089
  • Antioxidants (Basel).2019, 8(8):E307
  • Food Funct.2020, 10.1039
  • Food and Chemical Toxicology2020, 111221
  • ...
  • 生物活性
    Description: Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervical carcinoma cells with an IC(50) value of 17.3 +/- 0.3 microM.
    In vitro:
    Mol Cell Proteomics. 2008 May;7(5):949-61.
    Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network.[Pubmed: 18166740]
    Triterpenes isolated from Ganoderma lucidum could inhibit the growth of numerous cancer cell lines and were thought to be the basis of the anticancer effects of G. lucidum. Ganoderic acid D (GAD) is one of the major components in Ganoderma triterpenes. GAD treatment for 48 h inhibited the proliferation of HeLa human cervical carcinoma cells with an IC(50) value of 17.3 +/- 0.3 microM. Flow cytometric analysis and DNA fragmentation analysis indicated that Ganoderic acid D induced G(2)/M cell cycle arrest and apoptosis.
    To identify the cellular targets of Ganoderic acid D, two-dimensional gel electrophoresis was performed, and proteins altered in expressional level after Ganoderic acid D exposure of cells were identified by MALDI-TOF MS/MS. The regulation of proteins was also confirmed by Western blotting. The cytotoxic effect of Ganoderic acid D was associated with regulated expression of 21 proteins. Furthermore these possible Ganoderic acid D target-related proteins were evaluated by an in silico drug target searching program, INVDOCK. The INVDOCK analysis results suggested that Ganoderic acid D could bind six isoforms of 14-3-3 protein family, annexin A5, and aminopeptidase B. The direct binding affinity of Ganoderic acid D toward 14-3-3 zeta was confirmed in vitro using surface plasmon resonance biosensor analysis. In addition, the intensive study of functional association among these 21 proteins revealed that 14 of them were closely related in the protein-protein interaction network. They had been found to either interact with each other directly or associate with each other via only one intermediate protein from previous protein-protein interaction experimental results. When the network was expanded to a further interaction outward, all 21 proteins could be included into one network.
    In this way, the possible network associated with Ganoderic acid D target-related proteins was constructed, and the possible contribution of these proteins to the cytotoxicity of Ganoderic acid D is discussed in this report.
    In vivo:
    Drug Metab Dispos. 2012 Dec;40(12):2307-14.
    Identification of metabolites of ganoderic acid D by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.[Pubmed: 22942320]
    Ganoderic acid D (GD) is the major active triterpenoid in Ganoderma lucidum, a medicinal fungus used daily. However, the metabolic fate of Ganoderic acid D remains unknown. To know whether Ganoderic acid D is extensively metabolized, we first investigated the metabolism of Ganoderic acid D in vitro and in vivo.
    The metabolic profiles of the bile samples obtained from rats in vivo were almost the same as those obtained in vitro. Using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry, a total of 25 metabolites were identified from the bile sample. Few metabolites were found in the urine samples. These results indicated that biliary rather than renal clearance was the major route of excretion. The major metabolites were identified by comparison with the standard reference compounds. Metabolites at low concentrations were identified by interpreting the mass spectra. Both phase I and phase II metabolites were observed. The metabolic transformation included reduction, monohydroxylation, dihydroxylation, trihydroxylation, oxidation, desaturation, sulfation, and glucuronidation. The main metabolic soft spots in the chemical structure of Ganoderic acid D were the 3-carbonyl group, angular methyl groups, the 7-hydroxy group, and the 26-carboxylic acid moiety.
    Overall, this study gives us an insight into the metabolism of Ganoderic acid D, an active oxygenated tetracyclic triterpenoid.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.943 mL 9.7152 mL 19.4303 mL 38.8606 mL 48.5758 mL
    5 mM 0.3886 mL 1.943 mL 3.8861 mL 7.7721 mL 9.7152 mL
    10 mM 0.1943 mL 0.9715 mL 1.943 mL 3.8861 mL 4.8576 mL
    50 mM 0.0389 mL 0.1943 mL 0.3886 mL 0.7772 mL 0.9715 mL
    100 mM 0.0194 mL 0.0972 mL 0.1943 mL 0.3886 mL 0.4858 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灵芝酸LM2; Ganoderic acid LM2 CFN90297 508182-41-0 C30H42O7 = 514.66 5mg QQ客服:215959384
    灵芝酸D; Ganoderic acid D CFN90292 108340-60-9 C30H42O7 = 514.66 10mg QQ客服:2159513211
    12-羟基灵芝酸D; 12-Hydroxyganoderic acid D CFN91921 942950-96-1 C30H42O8 = 530.65 10mg QQ客服:3257982914
    12β-灵芝酸M; Ganoderic acid M CFN90747 100761-17-9 C30H42O8 = 530.7 5mg QQ客服:2932563308
    灵芝酸Z; Ganoderic acid Z CFN90295 294674-09-2 C30H42O7 = 514.66 5mg QQ客服:1148253675
    灵芝酸AM1; Ganoderic acid AM1 CFN90296 149507-55-1 C30H42O7 = 514.66 5mg QQ客服:2932563308
    Ethyl ganoderate J; Ethyl ganoderate J CFN92576 1189555-95-0 C32H46O7 = 542.7 5mg QQ客服:1148253675
    灵芝酸B; Ganoderic acid B CFN92052 81907-61-1 C30H44O7 = 516.7 10mg QQ客服:215959384
    灵芝烯酸B; Ganoderenic acid B CFN92991 100665-41-6 C30H42O7 = 514.65 5mg QQ客服:1413575084
    灵芝酸C2; Ganoderic acid C2 CFN92054 103773-62-2 C30H46O7 = 518.7 10mg QQ客服:215959384





    在线QQ: 215959384


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产