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  • 黄颜木素

    Fustin

    黄颜木素
    产品编号 CFN98042
    CAS编号 20725-03-5
    分子式 = 分子量 C15H12O6 = 288.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The peels of Toxicodendron vernicifluum (Stokes) F. Barkley
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    黄颜木素 CFN98042 20725-03-5 1mg QQ客服:1148253675
    黄颜木素 CFN98042 20725-03-5 5mg QQ客服:1148253675
    黄颜木素 CFN98042 20725-03-5 10mg QQ客服:1148253675
    黄颜木素 CFN98042 20725-03-5 20mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Gyeongsang National University (Korea)
  • University of Liège (Belgium)
  • Medical University of South Carolina (USA)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • University of Illinois at Chicago (USA)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Subang Jaya Medical Centre (Malaysia)
  • MTT Agrifood Research Finland (Finland)
  • University of Limpopo (South Africa)
  • Nicolaus Copernicus Uniwersity (Poland)
  • University of Brasilia (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Research International2016, 106-113
  • University of Limpopo2016, 1-237
  • Molecules.2016, 21(6)
  • J Exp Bot.2016, 67(12):3777-88
  • Front Pharmacol.2016, 7:460
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • Korean J of Food Science&Technology 2017, 49(2):146-150
  • Front Aging Neurosci.2018, 10:269
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Fitoterapia.2018, 124:92-102
  • PLoS One.2018, 13(4):e0195642
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Evid Based Complement Alternat Med.2018, 2018:1073509
  • Mol Cells.2018, 41(8):771-780
  • Primary and Industrial.2018, 52(11)
  • Phytother Res.2019, 10.1002
  • Enzyme Microb Technol.2019, 122:64-73
  • J Pharm Biomed Anal.2019, 164:119-127
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • Molecules.2019, 24(17):E3127
  • J Mol Histol.2019, 50(4):343-354
  • Int J Oncol.2019, 55(1):320-330
  • Biomolecules.2019, 9(11):E696
  • ...
  • 生物活性
    Description: Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.
    Targets: Beta Amyloid | AChR | ERK | cAMP | PKC
    In vivo:
    J Neurosci Res. 2009 Dec;87(16):3658-70.
    Fustin flavonoid attenuates beta-amyloid (1-42)-induced learning impairment.[Pubmed: 19533734]
    Natural flavonoids ameliorate amyloid-beta peptide (Abeta)-induced neurotoxicity.
    METHODS AND RESULTS:
    We examined whether the Fustin flavonoid affects Abeta-induced learning impairment in mice. Repeated treatment with Fustin significantly attenuated Abeta (1-42)-induced conditioned fear and passive avoidance behaviors. This effect was comparable to that of EGb761, a standard extract of ginkgo. Fustin treatment significantly prevented decreases in acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene expression induced by Abeta (1-42). Fustin also consistently suppressed increases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Abeta (1-42). In addition, Fustin significantly attenuated Abeta (1-42)-induced selective decreases in muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity (as determined by [(3)H]pirenzepine binding) by modulating extracellular signal-regulated kinase 1/2 (ERK 1/2) and cAMP response-element binding protein (CREB) phosphorylation and brain-derived neurotrophic factor (BDNF) expression. These effects of Fustin were reversed by treatment with dicyclomine, a muscarinic M1 receptor antagonist, and SL327, a selective ERK inhibitor, but not by chelerythrine, a pan-protein kinase C (PKC) inhibitor.
    CONCLUSIONS:
    Taken together, our results suggest that Fustin attenuates Abeta (1-42)-impaired learning, and that the ERK/CREB/BDNF pathway is important for the M1 receptor-mediated cognition-enhancing effects of Fustin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4686 mL 17.343 mL 34.6861 mL 69.3722 mL 86.7152 mL
    5 mM 0.6937 mL 3.4686 mL 6.9372 mL 13.8744 mL 17.343 mL
    10 mM 0.3469 mL 1.7343 mL 3.4686 mL 6.9372 mL 8.6715 mL
    50 mM 0.0694 mL 0.3469 mL 0.6937 mL 1.3874 mL 1.7343 mL
    100 mM 0.0347 mL 0.1734 mL 0.3469 mL 0.6937 mL 0.8672 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2',3,5,6',7-四羟基二氢黄烷酮; 2',3,5,6',7-Pentahydroxyflavanone CFN97277 80366-15-0 C15H12O7 = 304.3 5mg QQ客服:2932563308
    二氢桑色素; Dihydromorin CFN99854 18422-83-8 C15H12O7 = 304.3 5mg QQ客服:1148253675
    二氢柽柳黄素; Dihydrotamarixetin CFN97194 70411-27-7 C16H14O7 = 318.3 5mg QQ客服:1413575084
    艾纳香素B; Blumeatin B CFN97274 79995-67-8 C17H16O7 = 332.3 5mg QQ客服:2159513211
    刺槐亭; Dihydrorobinetin CFN98671 4382-33-6 C15H12O7 = 304.3 20mg QQ客服:215959384
    蛇葡萄素; 二氢杨梅素; Ampelopsin CFN98326 27200-12-0 C15H12O8 = 320.3 20mg QQ客服:3257982914
    Sepinol; Sepinol CFN97204 72061-63-3 C16H14O7 = 318.3 5mg QQ客服:2932563308
    6-甲基二氢槲皮素; Cedeodarin CFN97912 31076-39-8 C16H14O7 = 318.3 5mg QQ客服:1413575084
    雪松素; Cedrin CFN97872 75513-81-4 C16H14O8 = 334.3 5mg QQ客服:2932563308
    (-)-二氢槲皮素; (-)-Dihydroquercetin CFN92413 111003-33-9 C15H12O7 = 304.3 5mg QQ客服:2932563308

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