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    大戟因子L1

    Euphorbia factor L1

    大戟因子L1
    产品编号 CFN92883
    CAS编号 76376-43-7
    分子式 = 分子量 C32H40O8 = 552.7
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Diterpenoids
    植物来源 The herbs of Euphorbia pekinensis Rupr.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    大戟因子L1 CFN92883 76376-43-7 10mg QQ客服:3257982914
    大戟因子L1 CFN92883 76376-43-7 20mg QQ客服:3257982914
    大戟因子L1 CFN92883 76376-43-7 50mg QQ客服:3257982914
    大戟因子L1 CFN92883 76376-43-7 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Eastern Finland (Finland)
  • National Chung Hsing University (Taiwan)
  • University of Mysore (India)
  • Kyushu University (Japan)
  • Agricultural Research Organization (ARO) (Israel)
  • University of the Basque Country (Spain)
  • Auburn University (USA)
  • University of East Anglia (United Kingdom)
  • Kamphaengphet Rajabhat University (Thailand)
  • University of Bordeaux (France)
  • The Australian National University (Australia)
  • Osmania University (India)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • PLoS One.2015, 10(5):e0127060
  • The Journal of Internal Korean Medicine2015, 36(4):486-497
  • Ind Crops Prod.2015, 67:185-191
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • Mediators Inflamm.2016, 2016:7216912
  • Phytochemistry.2017, 141:162-170
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • Mol Cell.2017, 68(4):673-685
  • J Nat Med.2017, 71(2):457-462
  • Journal of Third Military Medical University2018, 40(12):1073-1078
  • Cardiovasc Toxicol.2019, 19(4):297-305
  • Molecules.2019, 24(24):E4536
  • Environ Toxicol.2019, 34(12):1354-1362
  • J Sep Sci.2019, 42(21):3352-3362
  • Biomed Chromatogr.2019, 8:e4774
  • Appl. Sci.2020, 10,1304
  • J Pharmaceut Biomed2020, 182:113110
  • Crystals2020, 10(3), 206.
  • Advances in Traditional Medicine2020, 10.1007
  • Drug Chem Toxicol.2020, 1-14.
  • Research J. Pharm. and Tech.2020, 13(7):3059-3064.
  • Biochem Pharmacol. 2020, 177:114014.
  • J Biosci.2020, 45:46.
  • ...
  • 生物活性
    Description: Euphorbia factor L1 inhibits osteoclastogenesis and induces osteoclast apoptosis, it can enhance the ATP hydrolysis activity of ABCB1 stimulated by verapamil. Euphorbia factor L1 inhibits the efflux of ABCB1 in KBv200 and MCF-7/adr cells, does not downregulate their expression either in mRNA or protein level.
    Targets: ERK | Akt
    In vitro:
    Molecules. 2013 Oct 16;18(10):12793-808.
    Apoptosis sensitization by Euphorbia factor L1 in ABCB1-mediated multidrug resistant K562/ADR cells.[Pubmed: 24135937]

    METHODS AND RESULTS:
    In this article, reversal activities of Euphorbia factor L1 (EFL1) against ABCB1-mediated multidrug resistance (MDR) and apoptosis sensitization in K562/ADR cells are reported. EFL1 decreased the IC50 values of anticancer agents in K562/ADR cells over-expressing ABCB1. However, EFL1 did not affect the IC50 values of anticancer agents in sensitive K562 cells. Additionally, EFL1 increased the intracellular accumulation of rhodamine 123 and doxorubicin in K562/ADR cells without affecting their accumulation in K562 cells. Furthermore, EFL1 sensitized the apoptosis triggered by vincristine in K562/ADR cells via mitochondrial pathway, as confirmed by Annexin V-FITC/PI detection and western blot. At the same time, EFL1 did not influence the apoptosis induced by vincristine in K562 cells.
    CONCLUSIONS:
    Western blot results showed that EFL1 did not affect the phosphorylation level of AKT and ERK in K562 and K562/ADR cells. Finally, EFL1 did not down-regulate protein expression of ABCB1.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8093 mL 9.0465 mL 18.093 mL 36.186 mL 45.2325 mL
    5 mM 0.3619 mL 1.8093 mL 3.6186 mL 7.2372 mL 9.0465 mL
    10 mM 0.1809 mL 0.9046 mL 1.8093 mL 3.6186 mL 4.5232 mL
    50 mM 0.0362 mL 0.1809 mL 0.3619 mL 0.7237 mL 0.9046 mL
    100 mM 0.0181 mL 0.0905 mL 0.1809 mL 0.3619 mL 0.4523 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    大戟因子L7a; Euphorbia factor L7a CFN92885 93550-94-8 C33H40O7 = 548.7 5mg QQ客服:2932563308
    大戟因子L7b; Euphorbia factor L7b CFN91052 93550-95-9 C33H40O9 = 580.67 10mg QQ客服:2932563308
    Jolkinol A; Jolkinol A CFN92878 62820-11-5 C29H36O6 = 480.6 5mg QQ客服:3257982914
    环氧续随子醇; Epoxylathyrol CFN98559 28649-60-7 C20H30O5 = 350.45 20mg QQ客服:2932563308
    大戟因子L1; Euphorbia factor L1 CFN92883 76376-43-7 C32H40O8 = 552.7 20mg QQ客服:2056216494
    7-羟基千金子二萜醇; 7-beta-Hydroxylathyrol CFN92488 34208-98-5 C20H30O5 = 350.5 20mg QQ客服:3257982914
    5,15-二乙酰基-3-苯甲酰千金子二萜醇; 千金二萜醇二乙酰苯甲酰酯; 5,15-Diacetyl-3-benzoyllathyrol CFN99706 218916-52-0 C31H38O7 = 522.63 20mg QQ客服:1413575084
    大戟因子L8; Euphorbia factor L8 CFN92886 218916-53-1 C30H37NO7 = 523.6 5mg QQ客服:2056216494
    大戟因子L9; Euphorbia factor L9 CFN92887 129393-28-8 C37H41NO9 = 643.7 5mg QQ客服:1457312923
    大戟因子L2; Euphorbia factor L2 CFN92884 218916-51-9 C38H42O9 = 642.7 5mg QQ客服:2159513211

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