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  • Jolkinol A

    Jolkinol A

    Jolkinol A
    产品编号 CFN92878
    CAS编号 62820-11-5
    分子式 = 分子量 C29H36O6 = 480.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The seeds of Euphorbia lathyris L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Jolkinol A CFN92878 62820-11-5 1mg QQ客服:2056216494
    Jolkinol A CFN92878 62820-11-5 5mg QQ客服:2056216494
    Jolkinol A CFN92878 62820-11-5 10mg QQ客服:2056216494
    Jolkinol A CFN92878 62820-11-5 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Heidelberg University (Germany)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Amity University (India)
  • Ain Shams University (Egypt)
  • University of Parma (Italy)
  • University of Padjajaran (Indonesia)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Complutense University of Madrid (Spain)
  • University of Vigo (Spain)
  • Universidade Federal de Goias (UFG) (Brazil)
  • University of Otago (New Zealand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Green Chemistry2021, ISSUE 2.
  • Postharvest Biol Tec2019, 149:18-26
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • Plants (Basel).2021, 10(2):278.
  • J Sep Sci.2018, 41(7):1682-1690
  • Asian J of Pharmaceutical&Clinical 2018, 11(2)
  • Journal of Functional Foods2021, 84:104581
  • J Ethnopharmacol.2020, 249:112381
  • Chem Biol Interact.2018, 290:44-51
  • Separations2021, 8(6),80.
  • Horticulture Research2020, 7:111.
  • Front Pharmacol.2020, 11:566490.
  • J of App. Res. on Med&Aromatic Plants2020, 100291.
  • Nutrients.2019, 11(11):E2694
  • Inflammation2015, 38(1):445-55
  • Current Pharmaceutical Analysis2017, 13(5)
  • Mol Med Rep.2022, 26(4):299.
  • Plants (Basel).2023, 12(1):163.
  • J Ethnopharmacol.2017, 196:75-83
  • Food Chem Toxicol.2020, 135:110863
  • Pharmacia2022, 69(3): 883-890.
  • Int J Mol Sci.2022, 23(10):5468.
  • Front Pharmacol.2023, 14:1244655.
  • ...
  • 生物活性
    Description: Jolkinol A can inhibit both MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) cell lines, with GI50 values ranging between 40.9 microM and 95.3 microM.
    In vitro:
    Planta Med. 2004 Mar;70(3):244-9.
    Euphopubescenol and euphopubescene, two new jatrophane polyesters, and lathyrane-type diterpenes from Euphorbia pubescens.[Pubmed: 15114502]

    METHODS AND RESULTS:
    Two known lathyrane derivatives, Jolkinol A ( 3) and Jolkinol A ( 4), whose (13)C-NMR spectra were assigned, were also isolated. Compounds 1 - 3 have been evaluated for their ability to inhibit the in vitro growth of three human tumour cell lines representing different tumour types, MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and SF-268 (CNS cancer).
    CONCLUSIONS:
    They inhibited both MCF-7 and NCI-H460 cell lines, with GI50 values ranging between 40.9 microM and 95.3 microM, but were found to be ineffective as growth inhibitors of the SF-268 cell line
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0807 mL 10.4037 mL 20.8073 mL 41.6146 mL 52.0183 mL
    5 mM 0.4161 mL 2.0807 mL 4.1615 mL 8.3229 mL 10.4037 mL
    10 mM 0.2081 mL 1.0404 mL 2.0807 mL 4.1615 mL 5.2018 mL
    50 mM 0.0416 mL 0.2081 mL 0.4161 mL 0.8323 mL 1.0404 mL
    100 mM 0.0208 mL 0.104 mL 0.2081 mL 0.4161 mL 0.5202 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    大戟因子L1; Euphorbia factor L1 CFN92883 76376-43-7 C32H40O8 = 552.7 20mg QQ客服:2056216494
    脱氧大戟因子L1; Deoxy euphorbia factor L1 CFN95340 247099-01-0 C32H40O7 = 536.7 10mg QQ客服:1457312923
    新化合物IX; New compound 9 CFN95342 N/A C31H38O8 = 538.6 5mg QQ客服:2159513211
    7-羟基千金子二萜醇; 7-beta-Hydroxylathyrol CFN92488 34208-98-5 C20H30O5 = 350.5 20mg QQ客服:215959384
    大戟因子L3; Euphorbia factor L3 CFN99706 218916-52-0 C31H38O7 = 522.63 20mg QQ客服:215959384
    大戟因子L8; Euphorbia factor L8 CFN92886 218916-53-1 C30H37NO7 = 523.6 10mg QQ客服:1457312923
    大戟因子L9; Euphorbia factor L9 CFN92887 129393-28-8 C37H41NO9 = 643.7 5mg QQ客服:2159513211
    大戟因子L2; Euphorbia factor L2 CFN92884 218916-51-9 C38H42O9 = 642.7 20mg QQ客服:2159513211
    17-羟基异千金子二萜醇; 17-Hydroxyisolathyrol CFN93011 93551-00-9 C20H30O5 = 350.45 5mg QQ客服:3257982914
    大戟因子L22; Euphorbia factor L22 CFN95338 1613700-09-6 C31H38O6 = 506.6 5mg QQ客服:1413575084

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