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  • Eriosemation

    • Eriosemation

    Eriosemation

    Eriosemation
    		产品编号 CFN92835
    CAS编号 162616-72-0
    分子式 = 分子量 C19H22O4 = 314.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Lupinus luteus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Eriosemation CFN92835 162616-72-0 1mg QQ客服：1413575084
    Eriosemation CFN92835 162616-72-0 5mg QQ客服：1413575084
    Eriosemation CFN92835 162616-72-0 10mg QQ客服：1413575084
    Eriosemation CFN92835 162616-72-0 20mg QQ客服：1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • University of Limpopo (South Africa)
  • Universidad Veracuzana (Mexico)
  • Amity University (India)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Lodz University of Technology (Poland)
  • FORTH-IMBB (Greece)
  • Periyar University (India)
  • Stanford University (USA)
  • Universite de Lille1 (France)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Uniwersytet Gdański (Poland)
  • Kyushu University (Japan)
  • University of Toulouse (France)
  • Univerzita Karlova v Praze (Czech Republic)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Anal Bioanal Chem.2023, 415(9):1641-1655.
  • J Funct Foods2019, 54:449-456
  • Kaohsiung J Med Sci.2023, 10.1002/kjm2.12764
  • Front Plant Sci.2017, 8:723
  • Aging (Albany NY).2021, 13(19):22867-22882.
  • Toxicological Research2020, doi: 10.1007.
  • Research Square2023, 2883170.
  • J Control Release.2021, 336:159-168.
  • Molecules.2021, 26(16):4722.
  • Biosci Biotechnol Biochem.2020, 84(3):621-632
  • Biomolecules.2022, 12(12):1754.
  • Evid Based Complement Alternat Med.2021, 2021:8850744.
  • Cytotechnology.2017, 69(5):765-773
  • Molecules.2019, 24(19):E3417
  • Nat Prod Sci.2018, 24(3):206
  • J Ethnopharmacol.2020, 249:112381
  • Nutrients.2018, 10(12)
  • Planta Med.2016, 82(13):1208-16
  • J Food Composition and Analysis2022, 104417.
  • Vietnam J. Chemistry2022, 60(2):211-222
  • Toxicol Mech Methods.2021, 1-12.
  • J Cell Mol Med.2023, 27(11):1592-1602.
  • Molecules.2019, 24(4):E709
  • ...
    • 生物活性
    Description: Eriosemation significant androgen receptor (AR) inhibition activity, suggests that it could be a promising candidate for further evaluation for prostate cancer prevention or management.
    Targets: Androgen Receptor
    In vitro:
    Sci Rep. 2017 May 16;7(1):1955.
    Structure Based docking studies towards exploring potential anti-androgen activity of selected phytochemicals against Prostate Cancer.[Pubmed: 28512306 ]
    Prostate cancer (PCa) is the second most common malignancy amongst men worldwide. Under PCa maintenance therapy drugs acting as antagonists/partial agonists of hormone receptors against the prostate tissue are used in clinical practices. Prominent drugs being Cyproterone acetate, Flutamide, Bicalutamide, they not only cause acute and long-term toxicity, but also develops drug resistance among patients.Our focus has been on phytochemicals which do not exhibit any cytotoxicity and have significant androgen receptor (AR) inhibition activity.
    METHODS AND RESULTS:
    As Protein- Ligand interactions play a key role in structure based drug design, so by using molecular docking, we screened 803 phytochemicals and investigated their binding affinity against AR. The three dimensional (3D) structure of AR was retrieved from Protein Data Bank, and docked with 3D Pubchem structures of 803 phytochemicals using Argus Lab. Molecular docking and drug likeness studies were made using ADMET properties while Lipinski's rule of five was performed for the phytochemicals to evaluate their anti-prostate cancer activity.
    CONCLUSIONS:
    The results showed that Isobavachin exhibited best binding affinity of -13.73 kcal/mol with AR followed by Glabranin, Anthocyanin and Eriosemation. Our studies therefore reveal that these four phytochemicals could be promising candidates for further evaluation for PCa prevention or management.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1807 mL 15.9033 mL 31.8066 mL 63.6132 mL 79.5165 mL
    5 mM 0.6361 mL 3.1807 mL 6.3613 mL 12.7226 mL 15.9033 mL
    10 mM 0.3181 mL 1.5903 mL 3.1807 mL 6.3613 mL 7.9517 mL
    50 mM 0.0636 mL 0.3181 mL 0.6361 mL 1.2723 mL 1.5903 mL
    100 mM 0.0318 mL 0.159 mL 0.3181 mL 0.6361 mL 0.7952 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    白屈菜酸; Chelidonic acid CFN94111 99-32-1 C7H4O6 = 184.10 20mg QQ客服：2159513211
    去甲氧基茵陈色原酮; Demethoxycapillarisin CFN97716 61854-36-2 C15H10O6 = 286.24 5mg QQ客服：2159513211
    7-O-去甲氧基茵陈色原酮; Demethoxy-7-O-methylcapillarisin CFN96209 61854-37-3 C16H12O6 = 300.3 5mg QQ客服：3257982914
    茵陈色原酮; Capillarisin CFN90317 56365-38-9 C16H12O7 = 316.26 5mg QQ客服：1413575084
    Epimedonin B; Epimedonin B CFN92907 1616061-69-8 C20H16O6 = 352.34 5mg QQ客服：2056216494
    5,7-二羟基色原酮; 5,7-Dihydroxychromone CFN97761 31721-94-5 C9H6O4 = 178.14 20mg QQ客服：3257982914
    5,7-二羟基色原酮 7-芸香糖苷; 5,7-Dihydroxychromone 7-rutinoside CFN92369 52538-46-2 C21H26O13 = 486.4 5mg QQ客服：1457312923
    3,5,7-三羟基色原酮; 3,5,7-Trihydroxychromone CFN89191 31721-95-6 C9H6O5 = 194.14 5mg QQ客服：2159513211
    Eriosematin A; Eriosematin A CFN92552 175448-02-9 C14H14O4 = 246.3 5mg QQ客服：1457312923
    Eriosemation; Eriosemation CFN92835 162616-72-0 C19H22O4 = 314.4 5mg QQ客服：2056216494

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