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  • 大黄素-8-β-D-吡喃葡萄糖苷

    Emodin-8-beta-D-glucoside

    大黄素-8-β-D-吡喃葡萄糖苷
    产品编号 CFN99572
    CAS编号 23313-21-5
    分子式 = 分子量 C21H20O10 = 432.41
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Anthraquinones
    植物来源 The roots and rhizomes of Rheum palmatum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    大黄素-8-β-D-吡喃葡萄糖苷 CFN99572 23313-21-5 10mg QQ客服:2932563308
    大黄素-8-β-D-吡喃葡萄糖苷 CFN99572 23313-21-5 20mg QQ客服:2932563308
    大黄素-8-β-D-吡喃葡萄糖苷 CFN99572 23313-21-5 50mg QQ客服:2932563308
    大黄素-8-β-D-吡喃葡萄糖苷 CFN99572 23313-21-5 100mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Shanghai University of TCM (China)
  • Gyeongsang National University (Korea)
  • Universidade Federal de Santa Catarina (Brazil)
  • Kitasato University (Japan)
  • Julius Kühn-Institut (Germany)
  • Universidad Veracuzana (Mexico)
  • St. Jude Children Research Hospital (USA)
  • Universidade do Porto (Portugal)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • University of Wuerzburg (Germany)
  • University of Maryland (USA)
  • Universite de Lille1 (France)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • University of Melbourne (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules. 2013, 18(7):7376-88
  • BMC Complement Altern Med.2014, 14:242
  • Plant Cell,Tissue & Organ Culture2016, 127(1):115-121
  • Am J Chin Med.2016, 44(6):1255-1271
  • Am J Chin Med.2016, 44(8):1719-1735
  • J Separation Science & Technology2016, 51:1579-1588
  • Research on Crops.2017, 18(3):569
  • Journal of Functional Foods2017, 30:30-38
  • Srinagarind Medical Journal2017, 32(1)
  • Arch Toxicol.2017, 91(10):3225-3245
  • South African J of Plant&Soil2018, 29-32
  • Planta Med.2018, 84(6-07):465-474
  • Phytother Res.2019, 10.1002
  • Nutr Metab (Lond).2019, 16:31
  • Exp Ther Med.2019, 18(6):4388-4396
  • BMC Complement Altern Med.2019, 19(1):339
  • J Ethnopharmacol.2019, 228:132-141
  • J Ethnopharmacol.2019, 235:406-414
  • Molecules.2019, 24(23):E4303
  • Chin J Appl. Physiol.2019, 35(3):283-288
  • Sci Rep.2019, 9(1):4342
  • Pharmacological Reports2020, 1-9
  • J Ethnopharmacol.2020, 249:112381
  • ...
  • 生物活性
    Description: Emodin-8-beta-D-glucoside functions to protect from focal cerebral injury induced by ischemia and reperfusion. It directly stimulates cell proliferation and differentiation of osteoblasts.
    Targets: PGE | TNF-α
    In vitro:
    Molecules. 2011 Jan 18;16(1):728-37.
    Emodin-8-O-β-D-glucoside from Polygonum amplexicaule D. Don var. sinense Forb. promotes proliferation and differentiation of osteoblastic MC3T3-E1 cells.[Pubmed: 21245807 ]
    Polygonum amplexicaule D. Don var. sinense Forb. (Polygonaceae) (PAF) is a famous traditional herb used to treat fractures, rheumatoid arthritis, muscle injury and pain.
    METHODS AND RESULTS:
    The present study was designed to investigate a PAF derived-chemical compound Emodin-8-beta-D-glucoside (EG) on the proliferation and differentiation of osteoblastic MC3T3-E1 cell in vitro. A compound was isolated from PAF extract by HPLC and identified as emodin-8-O-β-D-glucoside (EG) by spectroscopic methods. EG significantly promoted cell proliferation at 0.1-100 ng/mL, and increased the cell proportion in S-phase from 16.34% to 32.16%. Moreover, EG increased alkaline phosphatase (ALP) expression in MC3T3-E1 cells at the concentration from 0.1 to 100 ng/mL and inhibited PGE(2 )production induced by TNF-α in osteoblasts at the concentrations ranging from 10-100 ng/mL, suggesting that cell differentiation was induced in MC3T3-E1 osteoblasts.
    CONCLUSIONS:
    Taken together, these results indicated compound EG directly stimulated cell proliferation and differentiation of osteoblasts, therefore this study preliminarily explored the pharmacological mechanism of PAF to promote the healing of bone rheumatism and various fractures.
    In vivo:
    Eur J Pharmacol. 2007 Dec 22;577(1-3):58-63.
    Neuroprotective effects of emodin-8-O-beta-D-glucoside in vivo and in vitro.[Pubmed: 17897641 ]
    Emodin-8-O-beta-D-glucoside(Emodin-8-beta-D-glucoside) extracted from the traditional Chinese medicinal herb Polygonum cuspidatum Sieb. et Zucc is widely used to treat acute hepatitis possibly by antioxidative mechanisms. The present study was designed to investigate whether emodin-8-O-beta-D-glucoside(Emodin-8-beta-D-glucoside)exerted neuroprotective effects on the focal cerebral injury induced by ischemia and reperfusion in vivo and on the neuronal damage induced by glutamate in vitro, and to study the possible mechanisms.
    METHODS AND RESULTS:
    Male Wistar rats were used to establish the model of ischemia and reperfusion. The behavioral test was performed and the cerebral infarction area was assessed in the brain slices stained with 2% 2,3,5-triphenyl tetrazolium chloride to evaluate the neuroprotective effects of emodin-8-O-beta-D-glucoside(Emodin-8-beta-D-glucoside). Superoxide dismutase (SOD) activity, total antioxidative capability and malondialdehyde (MDA) level in the brain tissue were determined with spectrophotometrical methods to probe the primary mechanisms of emodin-8-O-beta-D-glucoside(Emodin-8-beta-D-glucoside). In vitro, the neuroprotective effects of emodin-8-O-beta-D-glucoside(Emodin-8-beta-D-glucoside) were tested in the cultured cortical cells of fetal rats exposed to glutamate. Emodin-8-O-beta-D-glucoside(Emodin-8-beta-D-glucoside) concentration in plasma and brain tissue was also measured to examine distribution of emodin-8-O-beta-D-glucoside(Emodin-8-beta-D-glucoside) in the brain. The results showed that the treatment of rats with emodin-8-O-beta-D-glucoside(Emodin-8-beta-D-glucoside) reduced the neurological deficit score and the cerebral infarction area, increased SOD activity and total antioxidative capability, and decreased MDA level in the brain tissue in dose-dependent way. Emodin-8-O-beta-D-glucoside(Emodin-8-beta-D-glucoside) also inhibited the neuronal damage induced by glutamate. Besides, emodin-8-O-beta-D-glucoside(Emodin-8-beta-D-glucoside) was able to penetrate blood-brain barrier and distribute in the brain tissue.
    CONCLUSIONS:
    These findings demonstrate that emodin-8-O-beta-D-glucoside(Emodin-8-beta-D-glucoside) is able to provide neuroprotection against cerebral ischemia-reperfused injury and glutamate induced neuronal damage through exerting antioxidative effects and inhibiting glutamate neurotoxicity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3126 mL 11.5631 mL 23.1262 mL 46.2524 mL 57.8155 mL
    5 mM 0.4625 mL 2.3126 mL 4.6252 mL 9.2505 mL 11.5631 mL
    10 mM 0.2313 mL 1.1563 mL 2.3126 mL 4.6252 mL 5.7815 mL
    50 mM 0.0463 mL 0.2313 mL 0.4625 mL 0.925 mL 1.1563 mL
    100 mM 0.0231 mL 0.1156 mL 0.2313 mL 0.4625 mL 0.5782 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    大黄素-8-O-β-龙胆二糖; Emodin-8-O-beta-gentiobioside CFN95132 66466-22-6 C27H30O15 = 594.5 5mg QQ客服:1413575084
    大黄素甲醚-8-O-β-D-葡萄糖苷; Physcion 8-O-beta-D-monoglucoside CFN80399 23451-01-6 C22H22O10 = 446.4 5mg QQ客服:2159513211
    大黄素甲醚-8-O-芸香糖苷; Physcion 8-O-rutinoside CFN89023 129393-21-1 C28H32O14 = 592.55 5mg QQ客服:215959384
    葡欧鼠李苷 A; Glucofrangulin A CFN70246 21133-53-9 C27H30O14 = 578.5 5mg QQ客服:2159513211
    葡欧鼠李苷 B; Glucofrangulin B CFN70247 14062-59-0 C26H28O14 = 564.5 5mg QQ客服:2932563308
    大黄素甲醚-1-O-β-D-葡萄糖苷; Physcion 1-O-beta-D-glucoside CFN91103 26296-54-8 C22H22O10 = 446.41 5mg QQ客服:2932563308
    芦西定 3-O-葡萄糖苷; Lucidin 3-O-glucoside CFN91032 22255-29-4 C21H20O10 = 432.38 5mg QQ客服:2159513211
    1,3,6-三羟基-2-甲基蒽醌-3-O-新橙皮糖苷; 1,3,6-Trihydroxy-2-methylanthraquinone 3-O-alpha-L-rhamnosyl-(1->2)-beta-D-glucoside CFN95096 87686-88-2 C27H30O14 = 578.5 5mg QQ客服:3257982914
    檄树素苷; Morindin CFN70420 60450-21-7 C26H28O14 = 564.5 5mg QQ客服:2159513211
    大黄酸-8-葡萄糖苷钙盐; Rhein-8-glucoside calcium salt CFN99592 113443-70-2 C21H16O11.Ca = 484.43 20mg QQ客服:2159513211

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