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  • 天然维生素E

    DL-alpha-Tocopherol

    天然维生素E
    产品编号 CFN90041
    CAS编号 59-02-9
    分子式 = 分子量 C29H50O2 = 430.7
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Phenols
    植物来源 The herbs of Isodon adenantha
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Sant Gadge Baba Amravati University (India)
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  • University Medical Center Mainz (Germany)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean Journal of Pharmacognosy.2015, 46(4):352-364
  • Ind Crops Prod.2015, 67:185-191
  • J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
  • Sci Rep.2016, 6:25094
  • Free Radic Biol Med.2017, 112:191-199
  • Pharmacognosy Magazine2017, 13(52):868-874
  • Mol Cell.2017, 68(4):673-685
  • LWT-Food Science and Technology2017, 75:488-496
  • Front Aging Neurosci.2018, 10:269
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • Front Pharmacol.2018, 9:236
  • BMC Microbiol.2019, 19(1):78
  • Int J Mol Sci.2019, 20(21):E5488
  • J Ethnopharmacol.2019, 228:132-141
  • Food Chem.2019, 290:286-294
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • J Sep Sci.2019, 42(21):3352-3362
  • Process Biochemistry2019, 87:213-220
  • Oxid Med Cell Longev2020, 12
  • J Nat Med.2020, 74(1):65-75
  • Biosci Biotechnol Biochem.2020, 84(3):621-632
  • ...
  • 生物活性
    Description: DL-alpha-tocopherol, a potent inhibitor of phorbol ester induced shape change of erythro- and megakaryoblastic leukemia cells. DL-alpha-tocopherol acetate protects endothelial cell membranes from oxidative damage and disruption and limits the magnitude of haemorrhage and its spread from the subependyma into the ventricles; it also protects human skin fibroblasts against the cytotoxic effect of UVB, and its mechanism seems to be related to inhibition of UV-induced lipid peroxidation or to the antioxidation effect of dl-alpha-tocopherol.
    Targets: PKC
    In vitro:
    Photodermatol Photoimmunol Photomed. 1990 Aug;7(4):173-7.
    Protective effect of dl-alpha-tocopherol on the cytotoxicity of ultraviolet B against human skin fibroblasts in vitro.[Pubmed: 2076374]
    The effect of DL-alpha-Tocopherol on ultraviolet light, 280-320 nm (UVB)-induced damage of human skin fibroblasts was studied by measuring the colony-forming ability, unscheduled DNA synthesis (UDS) and malondialdehyde (MDA) production.
    METHODS AND RESULTS:
    Regarding the cell toxicity, the values of the mean lethal dose (D0) of UV in fibroblast strains from 5 normal subjects were examined. D0 increased dose-dependently when the cells were cultured in the presence of DL-alpha-Tocopherol at the concentration of 10-1000 micrograms/ml. UDS induced by 500 J/m2 UVB irradiation was not altered by treatment of 100 micrograms/ml DL-alpha-Tocopherol. MDA did not increase after 500 J/m2 UVB irradiation in the fibroblasts cultured with 100 micrograms/ml DL-alpha-Tocopherol, while MDA in the fibroblasts cultured without DL-alpha-Tocopherol increased after irradiation.
    CONCLUSIONS:
    These results suggest that DL-alpha-Tocopherol protects human skin fibroblasts against the cytotoxic effect of UVB, and its mechanism seems to be related to inhibition of UV-induced lipid peroxidation or to the antioxidation effect of DL-alpha-Tocopherol.
    In vivo:
    Kidney Int. 2002 Sep;62(3):877-84.
    Effect of antioxidant therapy with dl-alpha-tocopherol on cardiovascular structure in experimental renal failure.[Pubmed: 12164869]

    METHODS AND RESULTS:
    To investigate whether antioxidative therapy with DL-alpha-Tocopherol (Toco; vitamin E) interferes with the development of abnormal cardiovascular structure in experimental renal failure, 28 male Sprague-Dawley rats were subjected to partial renal ablation (subtotal nephrectomy, SNX) or to sham operation (sham). SNX were either left untreated or received the antioxidant Toco (2 x 1500 IE/kg BW/week in the pellets). Blood pressure was measured using tail plethysmography. The experiment was terminated after 12 weeks. Heart and left ventricular weight were determined and the following parameters were measured using morphometry and stereology: volume densities of cardiomyocytes, capillaries and non-vascular interstitium; length density and total length of cardiac capillaries, wall thickness of intramyocardial arterioles and of the aorta. Systolic blood pressure and body weight were comparable in all groups. Treatment with Toco led to significantly increased plasma concentrations of Toco. Left ventricular weight and wall thickness of intramyocardial arteries were significantly higher in both SNX groups compared to sham controls. Volume density of the cardiac interstitial tissue was significantly higher in untreated SNX than in Toco treated SNX and sham control rats. Length density of capillaries was significantly lower in untreated SNX than in control rats; however, the values were significantly higher, and even higher than in sham controls, when SNX were treated with Toco.
    CONCLUSIONS:
    Treatment with the antioxidant DL-alpha-Tocopherol prevented cardiomyocyte/capillary mismatch, and to some extent also myocardial fibrosis in rats with renal failure. The results point to a role of oxidative stress in the genesis of myocardial interstitial fibrosis and capillary deficit of the heart.
    Br Med J (Clin Res Ed). 1983 Jul 9;287(6385):81-4.
    Protective effect of vitamin E (DL-alpha-tocopherol) against intraventricular haemorrhage in premature babies.[Pubmed: 6407714 ]

    METHODS AND RESULTS:
    Forty four babies, of less than 32 weeks' gestation, were either randomly given 25 mg/kg vitamin E (DL-alpha-Tocopherol acetate) intramuscularly after birth (day 0) and on days 1, 2, and 3 or served as controls. Frequent real time ultrasound examinations of the brain were made in each baby during the first week and less frequently thereafter. In babies under 32 weeks' gestation the incidence of intraventricular haemorrhage was lower in supplemented babies (18.8%) compared with the controls (56.3%). On days 0, 1, 2, and 3 median plasma vitamin E concentrations in babies without haemorrhage and in those with subependymal haemorrhage only were similar. Babies with intraventricular haemorrhage had lower median concentrations on day 1 (p less than 0.002) and day 2 (p less than 0.05) compared with those with subependymal haemorrhage and lower concentrations on day 0 (p less than 0.02) and day 1 (p less than 0.05) compared with those without haemorrhage.
    CONCLUSIONS:
    These findings suggest that in premature babies vitamin E, an antioxidant, protects endothelial cell membranes from oxidative damage and disruption and limits the magnitude of haemorrhage and its spread from the subependyma into the ventricles.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3218 mL 11.609 mL 23.218 mL 46.436 mL 58.045 mL
    5 mM 0.4644 mL 2.3218 mL 4.6436 mL 9.2872 mL 11.609 mL
    10 mM 0.2322 mL 1.1609 mL 2.3218 mL 4.6436 mL 5.8045 mL
    50 mM 0.0464 mL 0.2322 mL 0.4644 mL 0.9287 mL 1.1609 mL
    100 mM 0.0232 mL 0.1161 mL 0.2322 mL 0.4644 mL 0.5805 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (+)-Delta-生育酚; (+)-Delta-Tocopherol CFN91145 119-13-1 C27H46O2 = 402.7 20mg QQ客服:3257982914
    Confluentin; Confluentin CFN98991 585534-03-8 C22H30O2 = 326.5 5mg QQ客服:2159513211
    Daurichromenic acid; Daurichromenic acid CFN97302 82003-90-5 C23H30O4 = 370.5 5mg QQ客服:1413575084
    Beta-生育三烯酚; Beta-Tocotrienol CFN92822 490-23-3 C28H42O2 = 410.6 5mg QQ客服:2932563308
    5,8-二甲基母育酚/维生素E; Beta-Tocopherol CFN96393 148-03-8 C28H48O2 = 416.7 5mg QQ客服:215959384
    Gamma-生育三烯酚; Gamma-Tocotrienol CFN92817 14101-61-2 C28H42O2 = 410.6 5mg QQ客服:3257982914
    Alpha-生育三烯酚; Alpha-Tocotrienol CFN92821 1721-51-3 C29H44O2 = 424.7 5mg QQ客服:3257982914
    天然维生素E; DL-alpha-Tocopherol CFN90041 59-02-9 C29H50O2 = 430.7 20mg QQ客服:1148253675
    α-生育酚醋酸酯; alpha-Tocopherol acetate CFN98999 58-95-7 C31H52O3 = 472.8 20mg QQ客服:2932563308
    去羟基-δ-生育酚,2,8-二甲基-2-(4,8,12-三甲基十三烷基)-2H-1-苯并吡喃-6-醇; Dehydro-δ-tocopherol CFN97674 802909-72-4 C27H44O2 = 400.65 5mg QQ客服:2159513211

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