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    Cyanidin-3-O-glucoside chloride

    产品编号 CFN99740
    CAS编号 7084-24-4
    分子式 = 分子量 C21H21O11 = 449.38
    产品纯度 >=98%
    物理属性 Red powder
    化合物类型 Flavonoids
    植物来源 The herbs of Chrysanthemum indicum
    产品名称 产品编号 CAS编号 包装 QQ客服
    氯化失车菊素-3-O-葡萄糖苷 CFN99740 7084-24-4 10mg QQ客服:2932563308
    氯化失车菊素-3-O-葡萄糖苷 CFN99740 7084-24-4 20mg QQ客服:2932563308
    氯化失车菊素-3-O-葡萄糖苷 CFN99740 7084-24-4 50mg QQ客服:2932563308
    氯化失车菊素-3-O-葡萄糖苷 CFN99740 7084-24-4 100mg QQ客服:2932563308
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  • 生物活性
    Description: Cyanidin-3- O -glucoside exhibits strong antioxidant activities, it has protective effects from blackberry extract against peroxynitrite-induced endothelial dysfunction and vascular failure. Cyanidin-3-O-glucoside chloride decreased mutant p21 expression, and increased the ratio of Bax/Bcl-2 and the activation of caspase-3 to induce apoptosis.
    Targets: Bcl-2/Bax | Caspase | p21
    In vitro:
    Life Sci. 2003 Jul 18;73(9):1097-114.
    Protective effects of cyanidin-3-O-glucoside from blackberry extract against peroxynitrite-induced endothelial dysfunction and vascular failure.[Pubmed: 12818719]
    Anthocyanins are a group of naturally occurring phenolic compounds as colorants in several plants, flowers and fruits. These pigments have a great importance as quality indicators, as chemotaxonomic markers and antioxidants.
    The content of blackberry (Rubus species) juice was investigated by HPLC/ESI/MS using narrow bore HPLC columns. Using this method we demonstrated that cyanidin-3-O-glucoside represents about 80% of the total anthocyanin contents in blackberry extract. Here we investigated antioxidant activity of the blackberry juice and cyanidin-3-O-glucoside on the endothelial dysfunction in cells and in vascular rings exposed to peroxynitrite. In human umbilical vein endothelial cells (HUVEC) in vitro, peroxynitrite caused a significant suppression of mitochondrial respiration (38 +/- 2.1% of control cells), as measured by the mitochondrial-dependent conversion of the dye MTT to formazan. Peroxynitrite caused DNA strand breakage (63 +/- 1.9% single strand vs 3 +/- 0.9% single strand in control cells), as measured by the alkaline unwinding assay, and caused an activation of PARS, as measured by the incorporation of radiolabeled NAD(+) to nuclear proteins. Blackberry juice (different dilutions that contained 80 ppm;40 ppm;14.5 ppm of cyanidin-3-O-glucoside) and cyanidin-3-O-glucoside (as chloride) (0.085 microM; 0.028 microM; 0.0085 microM) reduced the peroxynitrite-induced suppression of mitochondrial respiration, DNA damage and PARS activation in HUVECs. Vascular rings exposed to peroxynitrite exhibited reduced endothelium-dependent relaxant responses in response to acetylcholine as well as a vascular contractility dysfunction in response to norepinephrine. The development of this peroxynitrite-induced vascular dysfunction was ameliorated by the blackberry juice (different dilutions that contained 80 ppm;40 ppm;14.5 ppm of cyanidin-3-O-glucoside) and cyanidin-3-O-glucoside (as cyanidin-3-O-glucoside chloride) (0.085 microM;0.028 microM;0.0085 microM).
    In conclusion our findings clearly demonstrate that blackberry juice containing cyanidin-3-O-glucoside is a scavenger of peroxynitrite and that exert a protective effect against endothelial dysfunction and vascular failure induced by peroxynitrite.
    Int J Mol Sci. 2016 Jul; 17(7): 993.
    Cytotoxicity and Apoptotic Effects of Polyphenols from Sugar Beet Molasses on Colon Carcinoma Cells in Vitro[Pubmed: 27347927]
    Three polyphenols were isolated and purified from sugar beet molasses by ultrasonic-aid extraction and various chromatographic techniques, and their structures were elucidated by spectral analysis. Cytotoxicity and the molecular mechanism were measured by methyl thiazolyl tetrazolium (MTT) assay, flow cytometry, caspase-3 activity assay and Western blot assay. The results showed that gallic acid, cyanidin-3-O-glucoside chloride and epicatechin have cytotoxicity to the human colon, hepatocellular and breast cancer cells. Cyanidin-3-O-glucoside chloride showed its cytotoxicity against various tumor cell lines, particularly against colon cancer Caco-2 cells with half maximal inhibitory concentration (IC50) value of 23.21 ± 0.14 μg/mL in vitro. Cyanidin-3-O-glucoside chloride may be a potential candidate for the treatment of colon cancer. In the mechanism study, cyanidin-3-O-glucoside chloride increased the ratio of cell cycle at G0/G1 phase and reduced cyclin D1 expression on Caco-2 cells. Cyanidin-3-O-glucoside chloride decreased mutant p21 expression, and increased the ratio of Bax/Bcl-2 and the activation of caspase-3 to induce apoptosis.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2253 mL 11.1264 mL 22.2529 mL 44.5058 mL 55.6322 mL
    5 mM 0.4451 mL 2.2253 mL 4.4506 mL 8.9012 mL 11.1264 mL
    10 mM 0.2225 mL 1.1126 mL 2.2253 mL 4.4506 mL 5.5632 mL
    50 mM 0.0445 mL 0.2225 mL 0.4451 mL 0.8901 mL 1.1126 mL
    100 mM 0.0223 mL 0.1113 mL 0.2225 mL 0.4451 mL 0.5563 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    氯化失车菊素-3-O-葡萄糖苷; Cyanidin-3-O-glucoside chloride CFN99740 7084-24-4 C21H21O11 = 449.38 20mg QQ客服:2159513211
    氯化矢车菊素-3-O-(6''-丙二酰葡糖苷); Cyanidin-3-O-(6''-malonylglucoside) chloride CFN91864 171828-62-9 C24H23ClO14 = 570.9 5mg QQ客服:1413575084
    氯化失车菊素-3,5-O-双葡萄糖苷; Cyanidin-3,5-O-diglucoside chloride CFN92138 2611-67-8 C27H31O16Cl = 647.0 10mg QQ客服:215959384
    氯化失车菊素-3-O-桑布双糖苷; Cyanidin-3-O-sambubioside chloride CFN92173 33012-73-6 C26H29ClO15 = 617.0 10mg QQ客服:3257982914
    矢车菊素-3-O-半乳糖酸木糖甙氯化物; Cyanidin-3-O-lathyroside chloride CFN91866 31073-32-2 C26H29ClO15 = 617.0 5mg QQ客服:2932563308
    氯化矢车菊素-3-O-槐糖苷; Cyanidin 3-sophoroside chloride CFN90469 18376-31-3 C27H31O16.Cl = 646.99 5mg QQ客服:1148253675
    氯化失车菊素-3-O-芸香糖苷; Cyanidin-3-O-rutinoside chloride CFN92135 18719-76-1 C27H31O15Cl = 630.98 10mg QQ客服:1413575084
    矢车菊素-3-O-桑布双糖苷-5-O-葡萄糖苷; Cyanidin-3-O-sambubioside-5-O-glucoside chloride CFN91865 53925-33-0 C32H39ClO20 = 779.1 5mg QQ客服:1413575084
    Tricetinidin chloride; Tricetinidin chloride CFN91190 65618-21-5 C15H11ClO6 = 322.7 5mg QQ客服:215959384
    氯化矢车菊素; Cyanidin Chloride CFN99741 528-58-5 C15H11O6Cl = 322.70 20mg QQ客服:3257982914





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