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  • 柯里拉京

    Corilagin

    柯里拉京
    产品编号 CFN90176
    CAS编号 23094-69-1
    分子式 = 分子量 C27H22O18 = 634.45
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The herbs of Geranium wilfordii Maxim.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    柯里拉京 CFN90176 23094-69-1 10mg QQ客服:3257982914
    柯里拉京 CFN90176 23094-69-1 20mg QQ客服:3257982914
    柯里拉京 CFN90176 23094-69-1 50mg QQ客服:3257982914
    柯里拉京 CFN90176 23094-69-1 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Florida A&M University (USA)
  • Sapienza University of Rome (Italy)
  • University of Bordeaux (France)
  • University of Ioannina (Greece)
  • Kyoto University (Japan)
  • Periyar University (India)
  • Max Rubner-Institut (MRI) (Germany)
  • Tohoku University (Japan)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • University of Malaya (Malaysia)
  • Chang Gung University (Taiwan)
  • Universiti Sains Malaysia (Malaysia)
  • Max-Planck-Insitut (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2014, 14:242
  • Anticancer Res.2014, 34(7):3505-9
  • Mol Med Rep.2014, 9(5):1653-9
  • PLoS One.2015, 10(5):e0127060
  • Br J Pharmacol.2016, 173(2):396-410
  • Nat Prod Sci.2016, 22(2)
  • Oncotarget.2016, 8(51):88386-88400
  • Mol Pharm.2017, 14(9):3164-3177
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • Universite de Bordeaux2017, 2017BORD0867
  • J Nat Prod.2017, 80(4):854-863
  • European Journal of Integrative Medicine2018, 20:165-172
  • Biochem Biophys Res Commun.2018, 505(1):194-200
  • J Herbmed Pharmacol.2018, 7(4):280-286
  • Front Immunol.2018, 9:2655
  • Clin Transl Oncol.2019, 10.1007
  • Cancer Manag Res.2019, 11:483-500
  • Int J Mol Sci.2019, 20(16):E4015
  • Nat Prod Sci.2019, 25(3):238
  • Journal of Food Hygiene and Safety2019, 34(5):413-420
  • Food Funct.2020, 10.1039
  • J Pharmaceut Biomed2020, 178:112894
  • United States Patent Application2020, 20200038363
  • ...
  • 生物活性
    Description: Corilagin has antitumour, anti-inflammatory, antioxidant, antifibrotics, antiviral, antibacterial, hepatoprotective, antiatherogenic, and antihypertensive activities. Corilagin reduces the cytotoxicity induced by EV71 or CA16 on Vero cells with and IC50 value of 5.6 and 32.33 μg/mL, respectively; it shows the potential to protect against HSV-1-induced encephalitis, and the beneficial effects may be mediated by inhibiting TLR2 signaling pathways. Corilagin attenuates bleomycin-induced epithelial injury and fibrosis via inactivation of oxidative stress, proinflammatory cytokine release and NF-κB and TGF-β1 signaling; it suppresses the activity of beta-lactamase to some extent.
    Targets: TLR | TGF-β/Smad | LDL | HO-1 | HSV | IL Receptor | p65 | NF-kB | IkB | TNF-α | Akt | p53 | p21 | Caspase | Adrenergic Receptor | IKK
    In vitro:
    Phytother Res. 2014 May;28(5):781-3.
    Sensitization of Hep3B hepatoma cells to cisplatin and doxorubicin by corilagin.[Pubmed: 23913631]
    The anticancer action of gallotannins is a well-developed topic. We have demonstrated the in vivo antitumour activity of corilagin on Hep3B hepatoma using the xenograft athymic nude mice model.
    METHODS AND RESULTS:
    Here, we further report the potential sensitization of Hep3B hepatoma cells to cisplatin and doxorubicin by corilagin. Our results showed that corilagin is able to enhance the cytotoxicity of both cisplatin and doxorubicin on the Hep3B hepatoma cells.
    CONCLUSIONS:
    We speculate the possible use of corilagin in combination with low dosages of the anticancer chemotherapeutic standard drugs like cisplatin and doxorubicin, with the aim of obtaining an increment in the anticancer effect.
    Arch Pharm Res. 2015 Feb;38(2):193-202.
    Antiviral effects of Phyllanthus urinaria containing corilagin against human enterovirus 71 and Coxsackievirus A16 in vitro.[Pubmed: 24752860]
    Human enterovirus 71 (EV71) and Coxsackievirus A16 (CA16) are major causative agents of hand, foot, and mouth disease (HFMD) especially in infants and children under 5 years of age. Despite recent outbreaks of HFMD, there are no approved therapeutics against EV71 and CA16 infection. Moreover, in a small percentage of cases, the disease progression can lead to serious complications of the central nervous system.
    METHODS AND RESULTS:
    In this study, we investigated the antiviral effect of Corilagin and Phyllanthus urinaria extract, which contains Corilagin as a major component, on EV71 and CA16 infection in vitro. Our results indicate that Corilagin reduces the cytotoxicity induced by EV71 or CA16 on Vero cells with and IC50 value of 5.6 and 32.33 μg/mL, respectively. We confirmed the presence of Corilagin in EtOAc and BuOH fractions from P. urinaria extract and this correlated with antiviral activity of the fractions against EV71 or CA16. Future studies will be required to confirm the antiviral activity of Corilagin and P. urinaria extract in vivo. Challenging a model with a lethal dose of viral infection will be required to test this.
    CONCLUSIONS:
    Collectively, our work provides potential candidates for the development of novel drugs to treat HFMD.
    Microbiol Immunol. 2004;48(1):67-73.
    Mechanisms of action of corilagin and tellimagrandin I that remarkably potentiate the activity of beta-lactams against methicillin-resistant Staphylococcus aureus.[Pubmed: 14734860]
    Corilagin and tellimagrandin I are polyphenols isolated from the extract of Arctostaphylos uvaursi and Rosa canina L. (rose red), respectively. We have reported that corilagin and tellimagrandin I remarkably reduced the minimum inhibitory concentration (MIC) of beta-lactams in methicillin-resistant Staphylococcus aureus(MRSA).
    METHODS AND RESULTS:
    In this study, we investigated the effect of corilagin and tellimagrandin I on the penicillin binding protein 2 '(2a) (PBP2 '(PBP2a)) which mainly confers the resistance to beta-lactam antibiotics in MRSA. These compounds when added to the culture medium were found to decrease production of the PBP2 '(PBP2a) slightly. Using BOCILLIN FL, a fluorescent-labeled benzyl penicillin, we found that PBP2 '(PBP2a) in MRSA cells that were grown in medium containing corilagin or tellimagrandin I almost completely lost the ability to bind BOCILLIN FL. The binding activity of PBP2 and PBP3 were also reduced to some extent by these compounds.
    CONCLUSIONS:
    These results indicate that inactivation of PBPs, especially of PBP2 '(PBP2a), by corilagin or tellimagrandin I is the major reason for the remarkable reduction in the resistance level of beta-lactams in MRSA. Corilagin or tellimagrandin I suppressed the activity of beta-lactamase to some extent.
    In vivo:
    Int J Mol Sci. 2014 May 30;15(6):9762-79.
    Corilagin attenuates aerosol bleomycin-induced experimental lung injury.[Pubmed: 24886817]
    Idiopathic pulmonary fibrosis (IPF) is a progressing lethal disease with few clinically effective therapies. Corilagin is a tannin derivative which shows anti-inflammatory and antifibrotics properties and is potentiated in treating IPF.
    METHODS AND RESULTS:
    Here, we investigated the effect of Corilagin on lung injury following bleomycin exposure in an animal model of pulmonary fibrosis. Corilagin abrogated bleomycin-induced lung fibrosis as assessed by H&E; Masson's trichrome staining and lung hydroxyproline content in lung tissue. Corilagin reduced the number of apoptotic lung cells and prevented lung epithelial cells from membrane breakdown, effluence of lamellar bodies and thickening of the respiratory membrane. Bleomycin exposure induced expression of MDA, IKKα, phosphorylated IKKα (p-IKKα), NF-κB P65, TNF-α and IL-1β, and reduced I-κB expression in mice lung tissue or in BALF. These changes were reversed by high-dose Corilagin (100 mg/kg i.p) more dramatically than by low dose (10 mg/kg i.p). Last, Corilagin inhibits TGF-β1 production and α-SMA expression in lung tissue samples.
    CONCLUSIONS:
    Taken together, these findings confirmed that Corilagin attenuates bleomycin-induced epithelial injury and fibrosis via inactivation of oxidative stress, proinflammatory cytokine release and NF-κB and TGF-β1 signaling. Corilagin may serve as a promising therapeutic agent for pulmonary fibrosis.
    Phytomedicine. 2007 Nov;14(11):755-62.
    Antioxidant and hepatoprotective actions of medicinal herb, Terminalia catappa L. from Okinawa Island and its tannin corilagin.[Pubmed: 17293097 ]
    The antioxidant and hepatoprotective actions of Terminalia catappa L. collected from Okinawa Island were evaluated in vitro and in vivo using leaves extract and isolated antioxidants.
    METHODS AND RESULTS:
    A water extract of the leaves of T. catappa showed a strong radical scavenging action for 1,1-diphenyl-2-picrylhydrazyl and superoxide (O(2)(.-)) anion. Chebulagic acid and corilagin were isolated as the active components from T. catappa. Both antioxidants showed a strong scavenging action for O(2)(.-) and peroxyl radicals and also inhibited reactive oxygen species production from leukocytes stimulated by phorbol-12-myristate acetate. Galactosamine (GalN, 600 mg/kg, s.c.,) and lipopolysaccharide (LPS, 0.5 microg/kg, i.p.)-induced hepatotoxicity of rats as seen by an elevation of serum alanine aminotransferase, aspartate aminotransferase and glutathione S-transferase (GST) activities was significantly reduced when the herb extract or corilagin was given intraperitoneally to rats prior to GalN/LPS treatment. Increase of free radical formation and lipid peroxidation in mitochondria caused by GalN/LPS treatment were also decreased by pretreatment with the herb/corilagin. In addition, apoptotic events such as DNA fragmentation and the increase in caspase-3 activity in the liver observed with GalN/LPS treatment were prevented by the pretreatment with the herb/corilagin.
    CONCLUSIONS:
    These results show that the extract of T. catappa and its antioxidant, corilagin are protective against GalN/LPS-induced liver injury through suppression of oxidative stress and apoptosis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5762 mL 7.8808 mL 15.7617 mL 31.5234 mL 39.4042 mL
    5 mM 0.3152 mL 1.5762 mL 3.1523 mL 6.3047 mL 7.8808 mL
    10 mM 0.1576 mL 0.7881 mL 1.5762 mL 3.1523 mL 3.9404 mL
    50 mM 0.0315 mL 0.1576 mL 0.3152 mL 0.6305 mL 0.7881 mL
    100 mM 0.0158 mL 0.0788 mL 0.1576 mL 0.3152 mL 0.394 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2-肉桂酰-1-没食子酰葡萄糖; 2-Cinnamoyl-1-galloylglucose CFN95098 56994-83-3 C22H22O11 = 462.4 5mg QQ客服:2932563308
    1,2,3,4,6-五没食子酰葡萄糖; 1,2,3,4,6-O-Pentagalloylglucose CFN90192 14937-32-7 C41H32O26 = 940.68 20mg QQ客服:1413575084
    单宁酸; Tannic acid CFN90501 1401-55-4 C76H52O46 = 1701.2 20mg QQ客服:3257982914
    柯里拉京; Corilagin CFN90176 23094-69-1 C27H22O18 = 634.45 20mg QQ客服:3257982914
    诃子宁; Chebulanin CFN92294 166833-80-3 C27H24O19 = 652.5 5mg QQ客服:2932563308
    Thonningianin A; Thonningianin A CFN90633 271579-11-4 C42H34O21 = 874.7 10mg QQ客服:3257982914
    Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-β-D-glucose; Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-beta-D-glucose CFN90881 205370-59-8 C42H32O21 = 872.7 10mg QQ客服:1413575084
    老鹳草素; Geraniin CFN90256 60976-49-0 C41H28O27 = 952.64 20mg QQ客服:2932563308
    诃子鞣酸; Chebulagic acid CFN92295 23094-71-5 C41H30O27 = 954.7 5mg QQ客服:1148253675
    诃子林鞣酸; Chebulinic acid CFN92296 18942-26-2 C41H32O27 = 956.7 10mg QQ客服:2159513211

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