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  • 绿原酸

    Chlorogenic acid

    绿原酸
    产品编号 CFN99116
    CAS编号 327-97-9
    分子式 = 分子量 C16H18O9 = 354.31
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The barks of Eucommia ulmoides Oliv.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    绿原酸 CFN99116 327-97-9 10mg QQ客服:215959384
    绿原酸 CFN99116 327-97-9 20mg QQ客服:215959384
    绿原酸 CFN99116 327-97-9 50mg QQ客服:215959384
    绿原酸 CFN99116 327-97-9 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Universiti Malaysia Pahang (Malaysia)
  • National Hellenic Research Foundation (Greece)
  • University of Sao Paulo (Brazil)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • University of Otago (New Zealand)
  • Chang Gung University (Taiwan)
  • Universidade Católica Portuguesa (Portugal)
  • National Research Council of Canada (Canada)
  • Calcutta University (India)
  • University of Bonn (Germany)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Medical University of Gdansk (Poland)
  • National Cancer Institute (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2014, 14:352
  • Food Science and Biotechnology2015, 2205-2212
  • Acta Physiologiae Plantarum2016, 38:7
  • Nutrients.2017, 10(1)
  • International. J. of Food Properties 2017, 20:S131-S140
  • Mol Cell.2017, 68(4):673-685
  • LWT-Food Science and Technology2017, 75:488-496
  • Analytical Methods2018, 10(27)
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • Food Chem.2018, 252:207-214
  • Korean J Environ Agric.2018, 37(4):260-267
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • Mol Microbiol.2019, 112(1):317-332
  • Chinese Medicine2019, 14(1)
  • Int J Mol Sci.2019, 20(16):E4015
  • Life Sci.2019, 216:259-270
  • Exp Biol Med (Maywood).2019, 244(16):1463-1474
  • Srinagarind Medical Journal2019, 34(1)
  • Environ Toxicol.2019, 34(4):513-520.
  • Pharmaceutical Chemistry Journal2019, 52(12):986-991
  • Sci Rep.2019, 9(1):4342
  • J Nat Med.2020, 74(1):65-75
  • ...
  • 生物活性
    Description: Chlorogenic acid, a phenolic compound found ubiquitously in plants, is an antioxidant and metal chelator, it has antiviral activity by inhibiting HBV replication, it inhibits the inflammatory reaction in HSE via the suppression of TLR2/TLR9-Myd88 signaling pathways. Some derivatives of chlorogenic acid are hypoglycemic agents and may affect lipid metabolism, chlorogenic acid can improve glucose tolerance, decrease some plasma and liver lipids, and improve mineral pool distribution in vivo.
    Targets: HBV | PEG | NO | NOS | ERK | ROS | COX
    In vitro:
    Anticancer Drugs. 2015 Feb 24.
    Chlorogenic acid enhances the effects of 5-fluorouracil in human hepatocellular carcinoma cells through the inhibition of extracellular signal-regulated kinases.[Pubmed: 25714249]
    There is an urgent need to search for novel chemosensitizers in the field of cancer therapy. Chlorogenic acid (CGA), a type of polyphenol present in the diet, has many biological activities.
    METHODS AND RESULTS:
    The present study is designed to explore the influence of CGA on the effects of 5-fluorouracil (5-FU) on human hepatocellular carcinoma cells (HepG2 and Hep3B). Treatment with 5-FU induced the inhibition of hepatocellular carcinoma cells' proliferation, and the combined treatment with CGA enhanced this inhibition. 5-FU also increased the production of reactive oxygen species (ROS). The combination of 5-FU and CGA led to a more prominent production of ROS and significantly inactivated ERK1/2, although CGA and 5-FU exerted no significant changes when used alone. A previous report has shown that ROS are upstream mediators that inactivate ERK in hepatocellular carcinoma cells. Combined with our results, this indicates that the combination of 5-FU and CGA leads to the inactivation of ERK through the overproduction of ROS. This mediates the enhancement of 5-FU-induced inhibition of hepatocellular carcinoma cells' proliferation, that is, CGA sensitizes hepatocellular carcinoma cells to 5-FU treatment by the suppression of ERK activation through the overproduction of ROS.
    CONCLUSIONS:
    CGA has shown potential as a chemosensitizer of 5-FU chemotherapy in hepatocellular carcinoma.
    In vivo:
    Int J Pharm. 2011 Jan 17;403(1-2):136-8.
    In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid.[Pubmed: 20933071 ]
    Dietary polyphenols are thought to be beneficial for human health as antioxidants. Coffee beans contain a common polyphenol, chlorogenic acid. Chlorogenic acid is the ester of caffeic acid and quinic acid. Although these polyphenols have received much attention, there is little evidence indicating a relationship between the effect and the rate of absorption.
    METHODS AND RESULTS:
    In this study, we focused on the beneficial effects of chlorogenic acid and caffeic acid, a major metabolite of chlorogenic acid. We carried out in vitro and in vivo experiments. In the in vitro study, caffeic acid had stronger antioxidant activity than that of chlorogenic acid. The uptake of chlorogenic acid by Caco-2 cells was much less than that of caffeic acid. The physiological importance of an orally administered compound depends on its availability for intestinal absorption and subsequent interaction with target tissues. We then used an intestinal ischemia-reperfusion model to evaluate antioxidant activities in vivo.
    CONCLUSIONS:
    We found that both chlorogenic acid and caffeic acid had effects on intestinal ischemia-reperfusion injury. Since caffeic acid has a stronger antioxidant activity than that of chlorogenic acid and chlorogenic acid is hydrolyzed into caffeic acid in the intestine, it is possible that caffeic acid plays a major role in the protective effect of chlorogenic acid against ischemia-reperfusion injury.
    J Nutr Biochem. 2002 Dec;13(12):717-726.
    Chlorogenic acid modifies plasma and liver concentrations of: cholesterol, triacylglycerol, and minerals in (fa/fa) Zucker rats.[Pubmed: 12550056]
    Chlorogenic acid, a phenolic compound found ubiquitously in plants, is an in vitro antioxidant and metal chelator. Some derivatives of chlorogenic acid are hypoglycemic agents and may affect lipid metabolism. Concentrations of cholesterol and triacylglycerols are of interest due to their association with diseases such as non-insulin-dependent-diabetes- mellitus and obese insulin resistance.
    METHODS AND RESULTS:
    As little is known about the effects of chlorogenic acid in vivo, studies using obese, hyperlipidemic, and insulin resistant (fa/fa) Zucker rats were conducted to test the effect of chlorogenic acid on fasting plasma glucose, plasma and liver triacylglycerols and cholesterol concentrations. Aditionally, the effects of chlorogenic acid on selected mineral concentrations in plasma, spleen, and liver were determined. Rats were implanted with jugular vein catheters. Chlorogenic acid was infused (5 mg/Kg body weight/day) for 3 weeks via intravenous infusion. Chlorogenic acid did not promote sustained hypoglycemia and significantly lowered the postprandial peak response to a glucose challenge when compared to the same group of rats before Chlorogenic acid treatment. In Chlorogenic acid-treated rats, fasting plasma cholesterol and triacylglycerols concentrations significantly decreased by 44% and 58% respectively, as did in liver triacylglycerols concentrations (24%). We did not find differences (p > 0.05) in adipose triacylglycerols concentration. Significant differences (p < 0.05) in the plasma, liver, and spleen concentration of selected minerals were found in chlorogenic acid-treated rats.
    CONCLUSIONS:
    In vivo, chlorogenic acid was found to improve glucose tolerance, decreased some plasma and liver lipids, and improve mineral pool distribution under the conditions of this study.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8224 mL 14.1119 mL 28.2239 mL 56.4477 mL 70.5597 mL
    5 mM 0.5645 mL 2.8224 mL 5.6448 mL 11.2895 mL 14.1119 mL
    10 mM 0.2822 mL 1.4112 mL 2.8224 mL 5.6448 mL 7.056 mL
    50 mM 0.0564 mL 0.2822 mL 0.5645 mL 1.129 mL 1.4112 mL
    100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.5645 mL 0.7056 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5-O-阿魏酰奎尼酸; 5-O-Feruloylquinic acid CFN92889 40242-06-6 C17H20O9 = 368.3 5mg QQ客服:1413575084
    甲基 5-O-阿魏酰奎尼酸酯; Methyl 5-O-feruloylquinate CFN92445 154461-64-0 C18H22O9 = 382.4 5mg QQ客服:2159513211
    绿原酸; Chlorogenic acid CFN99116 327-97-9 C16H18O9 = 354.31 20mg QQ客服:215959384
    3-咖啡酰奎尼酸甲酯; 3-O-Caffeoylquinic acid methyl ester CFN92573 123483-19-2 C17H20O9 = 368.3 10mg QQ客服:215959384
    3-O-阿魏酰奎尼酸; 3-O-Feruloylquinic acid CFN92393 1899-29-2 C17H20O9 = 368.3 5mg QQ客服:1413575084
    甲基 3-O-阿魏酰奎尼酸酯; Methyl 3-O-feruloylquinate CFN92446 154418-15-2 C18H22O9 = 382.4 5mg QQ客服:2159513211
    Cyclohexanecarboxylic acid; Cyclohexanecarboxylic acid CFN92529 327161-03-5 C16H18O9 = 354.3 5mg QQ客服:2932563308
    隐绿原酸; Cryptochlorogenic acid CFN99117 905-99-7 C16H18O9 = 354.31 20mg QQ客服:3257982914
    甲基 4-咖啡酰奎尼酸酯; Methyl 4-caffeoylquinate CFN92528 123372-74-7 C17H20O9 = 368.3 5mg QQ客服:215959384
    4-O-阿魏酰奎尼酸; 4-O-Feruloylquinic acid CFN92392 2613-86-7 C17H20O9 = 368.3 5mg QQ客服:2159513211

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