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  • 蜂斗菜内酯A

    Bakkenolide A

    蜂斗菜内酯A
    产品编号 CFN98579
    CAS编号 19906-72-0
    分子式 = 分子量 C15H22O2 = 234.34
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Miscellaneous
    植物来源 The herbs of Petasites japonicus F. Schmidt
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    蜂斗菜内酯A CFN98579 19906-72-0 1mg QQ客服:2159513211
    蜂斗菜内酯A CFN98579 19906-72-0 5mg QQ客服:2159513211
    蜂斗菜内酯A CFN98579 19906-72-0 10mg QQ客服:2159513211
    蜂斗菜内酯A CFN98579 19906-72-0 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Queensland (Australia)
  • Yale University (USA)
  • University of Sao Paulo (Brazil)
  • Amity University (India)
  • University of Otago (New Zealand)
  • Medical University of South Carolina (USA)
  • The Ohio State University (USA)
  • Universidad Industrial de Santander (Colombia)
  • Max-Planck-Insitut (Germany)
  • Medical University of Gdansk (Poland)
  • The University of Newcastle (Australia)
  • Shanghai University of TCM (China)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • National Cancer Institute (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • JMicrobiol Biotech Food Sci2021, e4289.
  • Korean Journal of Pharmacognosy.2020, 51(2):100-106
  • Agronomy2023, 13(6), 1435.
  • Food Bioscience2022, 50:102187.
  • J Adv Res.2021, 35:245-257.
  • J Appl Pharm Sci.2022, 12(04):044-053
  • J Basic Clin Physiol Pharmacol.2016, 27(1):1-8
  • Food Chem.2023, 404(Pt A):134517.
  • Int. J. of Food Properties2017, S108-S118
  • Food Chem.2020, 313:126079
  • Toxicol Mech Methods.2021, 1-12.
  • J Am Soc Mass Spectrom.2021, 32(9):2451-2462.
  • J Formos Med Assoc.2020, S0929-6646(20)30425-3
  • Pharmaceutics.2022, 14(3):564.
  • EXCLI J.2023, 22:482-498.
  • Front Pharmacol.2021, 12:744624.
  • Biomed Pharmacother.2020, 131:110673.
  • Chinese Medicine2019, 14(1)
  • J.Pharm. & Biome. Anal.2023, 2: 100018.
  • Sci Rep.2023, 13(1):21690.
  • Molecules.2019, 24(21):E3834
  • Neurotoxicology.2022, 91:218-227.
  • Korean Journal of Pharmacognosy2018, 49(3):270-277
  • ...
  • 生物活性
    Description: Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related signaling pathways.
    Targets: HDAC | IkB | IL Receptor | Caspase | TNF-α | PI3K | Akt | GSK-3 | IKK
    In vitro:
    J.Appl. Entomol.,2010,107(1-5):524-9.
    Antifeedant and growth inhibitory effects of bakkenolide-A and other sesquiterpene lactones on the variegated cutworm, Peridroma saucia Huebner (Lep., Noctuidae). [Reference: WebLink]

    METHODS AND RESULTS:
    When added to artificial diets, the sesquiterpene lactone Bakkenolide A deterred feeding of neonate variegated cutworms in a choice test, and inhibited larval growth in a no-choice bioassay. In both bioassays, Bakkenolide A was more active against this polyphagous pest than several other sesquiterpene lactones previously shown to be active against other insects. In the choice test, older larvae (second instar) were found to be less sensitive to the antifeedant effect of Bakkenolide A than younger ones (first instar). Bakkenolide A also reduced larval growth and survival of second instar larvae when applied topically.
    CONCLUSIONS:
    Bioactivity of bakkenolide A via topical application was also greater than that of other sesquiterpene lactones tested.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.2673 mL 21.3365 mL 42.673 mL 85.3461 mL 106.6826 mL
    5 mM 0.8535 mL 4.2673 mL 8.5346 mL 17.0692 mL 21.3365 mL
    10 mM 0.4267 mL 2.1337 mL 4.2673 mL 8.5346 mL 10.6683 mL
    50 mM 0.0853 mL 0.4267 mL 0.8535 mL 1.7069 mL 2.1337 mL
    100 mM 0.0427 mL 0.2134 mL 0.4267 mL 0.8535 mL 1.0668 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    蜂斗菜内酯A; Bakkenolide A CFN98579 19906-72-0 C15H22O2 = 234.34 5mg QQ客服:1413575084
    蜂斗菜内酯 III ; Bakkenolide III CFN96942 24909-95-3 C15H22O4 = 266.33 5mg QQ客服:215959384
    1-氧蜂斗菜内酯S; 1-Oxobakkenolide S CFN96812 18456-02-5 C15H20O4 = 264.32 5mg QQ客服:3257982914
    蜂斗菜内酯 B ; Bakkenolide B CFN96902 18455-98-6 C22H30O6 = 390.47 5mg QQ客服:2056216494
    蜂斗菜内酯 IIIa ; Bakkenolide IIIa CFN89054 915289-60-0 C24H32O6S = 448.57 5mg QQ客服:2159513211
    蜂斗菜内酯 D; Bakkenolide D CFN90795 18456-03-6 C21H28O6S = 408.5 5mg QQ客服:2159513211
    蜂斗菜内酯 Db ; Bakkenolide Db CFN96815 226711-23-5 C21H28O7S = 424.50 5mg QQ客服:3257982914
    Glochicoccin D; Glochicoccin D CFN97495 927812-23-5 C21H24O10 = 436.4 5mg QQ客服:3257982914
    麝香酮; Muscone CFN99518 541-91-3 C16H30O = 238.42 20mg QQ客服:215959384
    Officinaruminane B; Officinaruminane B CFN92687 1246282-67-6 C29H36O = 400.6 5mg QQ客服:1457312923

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