假马齿苋皂苷II

Bacopaside II

	产品编号	CFN93234
	CAS编号	382146-66-9
	分子式 = 分子量	C₄₇H₇₆O₁₈ = 929.10
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The herbs of Bacopa monnieri
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产品名称	产品编号	CAS编号	包装	QQ客服
假马齿苋皂苷II	CFN93234	382146-66-9	1mg	QQ客服：2056216494
假马齿苋皂苷II	CFN93234	382146-66-9	5mg	QQ客服：2056216494
假马齿苋皂苷II	CFN93234	382146-66-9	10mg	QQ客服：2056216494
假马齿苋皂苷II	CFN93234	382146-66-9	20mg	QQ客服：2056216494

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Description:

Bacopaside II is a potential anti-angiogenic agent, it can reduce endothelial cell migration and tubulogenesis and induce apoptosis. Bacopaside II shows antioxidant and antidepressant activities, it can inhibit both basal activity as well as verapamil-stimulated ATPase activity, suggesting its affinity towards P-gp.

Targets:

P-gp | ATPase

In vitro:

Int J Mol Sci. 2018 Feb 26;19(3). pii: E653.

The Aquaporin 1 Inhibitor Bacopaside II Reduces Endothelial Cell Migration and Tubulogenesis and Induces Apoptosis.[Pubmed: 29495367]

Expression of aquaporin-1 (AQP1) in endothelial cells is critical for their migration and angiogenesis in cancer.
METHODS AND RESULTS:
We tested the AQP1 inhibitor, Bacopaside II, derived from medicinal plant Bacopa monnieri, on endothelial cell migration and tube-formation in vitro using mouse endothelial cell lines (2H11 and 3B11) and human umbilical vein endothelial cells (HUVEC). The effect of Bacopaside II on viability, apoptosis, migration and tubulogenesis was assessed by a proliferation assay, annexin-V/propidium iodide flow cytometry, the scratch wound assay and endothelial tube-formation, respectively. Cell viability was reduced significantly for 2H11 at 15 μM (p = 0.037), 3B11 at 12.5 μM (p = 0.017) and HUVEC at 10 μM (p < 0.0001). At 15 μM, the reduced viability was accompanied by an increase in apoptosis of 38%, 50% and 32% for 2H11, 3B11 and HUVEC, respectively. Bacopaside II at ≥10 μM significantly reduced migration of 2H11 (p = 0.0002) and 3B11 (p = 0.034). HUVECs were most sensitive with a significant reduction at ≥7.5 μM (p = 0.037). Tube-formation was reduced with a 15 μM dose for all cell lines and 10 μM for 3B11 (p < 0.0001).
CONCLUSIONS:
These results suggest that Bacopaside II is a potential anti-angiogenic agent.

In vivo:

Heliyon. 2016 Feb 15;2(2):e00068.

Beneficial effects of Bacopa monnieri extract on opioid induced toxicity.[Pubmed: 27441247]

The present study examined the hepatotoxicity and nephrotoxicity of morphine and illicit street heroin and their amelioration by a standardized methanolic extract of Bacopa monnieri (L.) (mBME) in rats.
METHODS AND RESULTS:
Morphine or street heroin was administered at a dose of 20 mg/kg for 14 and 21 days. mBME (40 mg/kg) or ascorbic acid (50 mg/kg) was administered two hours before morphine or street heroin. High performance liquid chromatography (HPLC) was used for the standardization of bacoside-A major components in mBME. The antioxidant potential of mBME was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay. Administration of morphine and street heroin resulted in marked elevation of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and creatinine. Histopathological changes induced by morphine and street heroin after 14 days were of reversible nature while treatment for 21 days was associated with irreversible changes. Pretreatment with mBME or ascorbic acid restored the elevation of serum ALT, AST and creatinine and protected liver and kidneys from the toxicological influence of morphine and street heroin. HPLC analysis showed that mBME contained bacoside-A major components i.e. bacoside A3 (37.5 μg/mg), Bacopaside II (4.62 μg/mg) and bacopasaponin C (1.91 μg/mg). The EC50 for the DPPH free radical scavenging assay revealed that mBME possessed strong antioxidant potential.
METHODS AND RESULTS:
These results concluded that as compared to morphine, street heroin was associated with severe biochemical and histopathological changes in the liver and kidneys. Bacopa monnieri having strong antioxidant potential may provide a beneficial herbal remedy for the efficient management of opioid related hepatotoxicity and nephrotoxicity.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
苦艾素A3; Bacoside A3	CFN91088	157408-08-7	C₄₇H₇₆O₁₈ = 929.11	10mg	QQ客服：3257982914
假马齿苋皂苷X; Bacopaside X	CFN91082	94443-88-6	C₄₆H₇₄O₁₇ = 899.08	5mg	QQ客服：3257982914
假马齿苋皂苷 I; Bacopaside I	CFN93076	382148-47-2	C₄₆H₇₄O₂₀S = 979.13	10mg	QQ客服：1457312923
假马齿苋皂苷II; Bacopaside II	CFN93234	382146-66-9	C₄₇H₇₆O₁₈ = 929.10	10mg	QQ客服：2056216494
假马齿苋皂苷V; Bacopaside V	CFN93267	620592-16-7	C₄₁H₆₆O₁₃ = 766.96	5mg	QQ客服：2056216494
假马齿苋皂苷IV; Bacopaside IV	CFN91182	155545-03-2	C₄₁H₆₆O₁₃ = 767.0	5mg	QQ客服：2159513211
假马齿苋皂苷N2; Bacopaside N2	CFN91081	871706-75-1	C₄₂H₆₈O₁₄ = 796.99	5mg	QQ客服：3257982914
假马齿苋皂素A; Bacoside A	CFN91080	11028-00-5	C₄₁H₆₈O₁₃ = 768.98	5mg	QQ客服：2056216494
假马齿苋皂苷C; Bacopasaponin C	CFN93219	178064-13-6	C₄₆H₇₄O₁₇ = 899.08	10mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.0763 mL	5.3816 mL	10.7631 mL	21.5262 mL	26.9078 mL
5 mM	0.2153 mL	1.0763 mL	2.1526 mL	4.3052 mL	5.3816 mL
10 mM	0.1076 mL	0.5382 mL	1.0763 mL	2.1526 mL	2.6908 mL
50 mM	0.0215 mL	0.1076 mL	0.2153 mL	0.4305 mL	0.5382 mL
100 mM	0.0108 mL	0.0538 mL	0.1076 mL	0.2153 mL	0.2691 mL

假马齿苋皂苷II

Bacopaside II

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